Seibutsu Butsuri
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
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Volume 48, Issue 3
Issue 277
Displaying 1-16 of 16 articles from this issue
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Perspective
Overview
  • High Resolution Solid-State NMR Opens a New Perspective in Structural Biology
    Hideo AKUTSU
    2008 Volume 48 Issue 3 Pages 154-160
    Published: 2008
    Released on J-STAGE: May 28, 2008
    DOIhttps://doi.org/10.2142/biophys.48.154
    JOURNAL FREE ACCESS
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    Recent developments of high-resolution solid-state NMR allow us detailed analyses of the structures and functions of biological supramolecular systems that are difficult for X-ray crystallography and solution NMR to tackle on. Magic angle spinning and recoupling of spin interactions provide high resolution and structural information, respectively. This method is powerful to investigate the atomic structures of amyloid fibrils, membrane-bound peptides, ligand-membrane protein complexes, intact phages and light-harvesting chlorosomes. This method will open a new frontier in structural biology. Collaborations among solid-state NMR, X-ray crystallography, electron microscopy and solution NMR will make a great contribution to the life science.
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Review
  • The Regulation of Cell-Response Heterogeneities Induced by Astrocytic Intracellular Enzyme Concentration
    Isao GOTO, Kiyohisa NATSUME
    2008 Volume 48 Issue 3 Pages 161-166
    Published: 2008
    Released on J-STAGE: May 28, 2008
    DOIhttps://doi.org/10.2142/biophys.48.161
    JOURNAL FREE ACCESS
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    Recently it is suggested that astrocyte processes information as well as neurons in brain. Neurotransmitter glutamate (Glu) induces several patterns of [Ca2+]i in astrocytes. In the present study, it is found that the patterns were induced with the change in the desensitization rate of metabotropic Glu receptor. The dependence of the frequency of the astrocytic [Ca2+]i oscillation on Glu concentration was also explained by the desensitization process. The process was regulated by the intracellular protein kinase and phosphatase. Thus, the intracellular protein kinase and phosphatase regulate which patterns of [Ca2+]i each astrocyte has against the Glu stimulation.
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  • Molecular Neurogenetics of Thermosensation and Temperature Learning in the Nematode C. elegans
    Atsushi KUHARA, Ikue MORI
    2008 Volume 48 Issue 3 Pages 167-173
    Published: 2008
    Released on J-STAGE: May 28, 2008
    DOIhttps://doi.org/10.2142/biophys.48.167
    JOURNAL FREE ACCESS
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    Elucidation of the principal mechanism for sensory transduction, learning and memory is a fundamental question in neuroscience. Thermotaxis, an experience-modulated behavior, in Caenorhabditis elegans is an ideal model to understand thermosensation and learning and memory. Recent genetic, behavioral and optical imaging studies of thermotaxis have begun to reveal molecular, cellular and neural circuit basis of thermosensation and neural plasticity.
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  • Modeling toward a Cellular Function in Real Space
    Shin-ichiro M. NOMURA, Ayako YAMADA, Kenichi YOSHIKAWA
    2008 Volume 48 Issue 3 Pages 174-179
    Published: 2008
    Released on J-STAGE: May 28, 2008
    DOIhttps://doi.org/10.2142/biophys.48.174
    JOURNAL FREE ACCESS
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    Cell-modeling research has been attracting increasing interests, as a potential methodology to understand the structure and function of living cells. We describe the recent development on the studies toward the construction of an artificial-cell-model. It is shown that protein synthesis of gene transcription/translation reaction proceeds within lipidic artificial-cell-models (in lipo), cell-sized liposomes, and water-in-oil droplets. As an experimental example, we describe the in lipo synthesis of functional membrane proteins. We also present the effects of confinement on the structural transition of actin filaments inside cell-sized compartments. We propose a theoretical model on the epigenetic control of the On/Off switching of genetic activity.
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Topics
Theoretical and experimental techniques
Salon
Activity of Regional Branch
Young Voice
Letters from Abroad
Promenade along Protein 3D Structures
Technical term
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