生物物理
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50 巻 , 2 号
通巻288号
選択された号の論文の20件中1~20を表示しています
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巻頭言
特集 日本発の生物物理学
解説
  • 朴 三用
    50 巻 (2010) 2 号 p. 074-079
    公開日: 2010/03/30
    ジャーナル フリー
    Influenza A virus is a major human and animal pathogen with the potential to cause catastrophic loss of life. Influenza virus reproduces rapidly, mutates frequently, and occasionally crosses species barriers. The recent emergence of swine-origin influenza H1N1 and avian influenza related to highly pathogenic forms of the human virus has highlighted the urgent need for new effective treatments. I describe two crystal structures of complexes made by fragments of PA and PB1, and PB1 and PB2. These novel interfaces are surprisingly small, yet they play a crucial role in regulating the 250 kDa polymerase complex, and are completely conserved among swine, avian and human influenza viruses. Given their importance to viral replication and strict conservation, the PA/PB1 and PB1/PB2 interfaces appear to be promising targets for novel anti-influenza drugs of use against all strains of influenza A virus. It is hoped that the structures presented here will assist the search for such compounds.
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総説
トピックス
トピックス(新進気鋭シリーズ)
談話室
支部だより
若手の声
海外だより
タンパク質立体構造散歩
用語解説
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