Seibutsu Butsuri
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
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Volume 50, Issue 5
Issue 291
Displaying 1-21 of 21 articles from this issue
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Perspective
Feature Articles Japanese Biophysics
Overview
  • Molecular Mechanism of Light-driven Ion Pumps
    Tsutomu KOUYAMA
    2010 Volume 50 Issue 5 Pages 222-227
    Published: 2010
    Released on J-STAGE: September 25, 2010
    DOIhttps://doi.org/10.2142/biophys.50.222
    JOURNAL FREE ACCESS
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    Crystallographic studies of archaeal light-driven ion pumps, including bacteriorhodopsin (BR) and halorhodopsin (HR), have shown that water molecules entrapped in protein cavities play an active role in the ion-translocation mechanism. On the basis of structural data of the reaction intermediates, we have proposed the hypothesis that BR functions as a proton/water antiporter, while HR functions as a proton/HCl antiporter.
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Review
  • Mechanism of “NBD engine” in an ABC transporter, CFTR channel
    Yoshiro SOHMA, Tzyh-Chang HWANG
    2010 Volume 50 Issue 5 Pages 228-231
    Published: 2010
    Released on J-STAGE: September 25, 2010
    DOIhttps://doi.org/10.2142/biophys.50.228
    JOURNAL FREE ACCESS
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    The cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ATP-binding cassette (ABC) transporter superfamily, is an anion channel which plays an important fundamental role in fluid and electrolyte transport across epithelial tissues. In the most of ABC transporters, two highly-conserved nucleotide-binding domains (NBDs) form a common engine that utilizes the energy of ATP hydrolysis to active-transport a wide spectrum of substrates. In CFTR, the ATP-dependent “NBD engine” drives the gate of the ion conducting pore by cycles of ATP binding and hydrolysis. In this review, we introduce the recent advances in the studies for the molecular mechanism of ATP-dependent NBD engine in CFTR channels.
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  • Self-assembled Structure of Amphiphiles by Coarse-grained Molecular Model
    Wataru SHINODA
    2010 Volume 50 Issue 5 Pages 232-235
    Published: 2010
    Released on J-STAGE: September 25, 2010
    DOIhttps://doi.org/10.2142/biophys.50.232
    JOURNAL FREE ACCESS
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    The recently developed coarse-grained (CG) molecular model enables us to investigate meso-scopic morphologies of self-assembly of amphiphilic molecules at the molecular level. The present CG model is designed to well reproduce the interfacial properties, solvation free energy, as well as molecular distribution obtained from simulations at the all-atomic detail. The transferability and versatility is demonstrated by applying the model to the bulk aqueous solution as well as to the air/water interfacial system.
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Topics
Topics (Young Scientist Series)
Theoretical and experimental techniques
Salon
Activity of Regional Branch
Young Voice
Letters from Abroad
Technical term
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