生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
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52 巻 , 6 号
通巻304号
選択された号の論文の19件中1~19を表示しています
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  • 榎本 匡宏, 石山 昇, SEO Min-Duk, AMADOR Fernando J., STATHOPULOS Peter B., 伊倉 ...
    52 巻 (2012) 6 号 p. 266-271
    公開日: 2012/11/27
    ジャーナル フリー
    Calcium (Ca2+) release from the sarco/endoplasmic reticulum stores generates vital regulatory signals in eukaryotes. The two major groups of Ca2+ release channels include the ubiquitously expressed inositol 1,4,5-trisphosphate receptors (IP3Rs) and the ryanodine receptors (RyRs). This review focuses on recently reported structural findings on the N-terminal regions of IP3Rs and RyRs and their arrangement into full-length tetrameric channels, revealing remarkable mechanistic homologies in Ca2+-release function. Additionally, we discuss genomic analyses identifying this class of Ca2+ release channels in unicellular organisms and the implications of these data in understanding the molecular evolution of these fundamental receptors in nature.
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  • 廣野 雅文
    52 巻 (2012) 6 号 p. 272-277
    公開日: 2012/11/27
    ジャーナル フリー
    Centrioles are cell organelles consisting of nine triplet microtubules arranged in rotational symmetry. This structure is highly conserved among various eukaryotic organisms and serves as the template for the “9 + 2” or “9 + 0” structures of ciliary axonemes. How this nine-fold symmetrical structure forms is a long-standing question. Recently, genetic approaches using Chlamydomonas revealed that the cartwheel, a sub-centriolar structure with a hub and nine spokes, plays a pivotal role in the establishment of nine-fold symmetry, and that a protein called SAS-6 is a key component of the cartwheel assembly. This review summarizes the Chlamydomonas studies and recent advances in the understanding the SAS-6 function.
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