生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
52 巻 , 1 号
通巻299号
選択された号の論文の22件中1~22を表示しています
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  • 小嶋 達矢, 林 勇樹, 菅 裕明
    2012 年 52 巻 1 号 p. 004-009
    発行日: 2012年
    公開日: 2012/01/31
    ジャーナル フリー
    Genetic code reprogramming enables us to assign nonproteinogenic amino acids to codons in place of proteinogenic amino acids according to the genetic code, which allows us to express desired nonstandard peptides using an in vitro translation system. Here, we discuss FIT (Flexible In vitro Translation) system, which is a method that facilitates genetic code reprogramming by employing flexizymes. Furthermore, we also report a method called RaPID (Random non-standard Peptide Integrated Discovery) system, which is an integration of FIT system with an in-vitro mRNA display. RaPID system allows us to select peptides with high binding affinities from highly diverse nonstandard peptide libraries and is quickly becoming a valuable new tool for drug discovery.
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