生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
54 巻, 6 号
通巻316号
選択された号の論文の17件中1~17を表示しています
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  • 宗 正智, 八木 寿梓, 後藤 祐児
    2014 年 54 巻 6 号 p. 297-302
    発行日: 2014年
    公開日: 2014/11/27
    ジャーナル フリー
    Protein crystals form in supersaturated solutions via a nucleation and growth mechanism. The amyloid fibrils of denatured proteins also form via a nucleation and growth mechanism. This similarity suggests that, although protein crystals and amyloid fibrils are distinct in their morphologies, both processes can be controlled in a similar manner. We show that ultrasonication is one of the most effective methods of agitation for accelerating spontaneous fibrillation. We also show that ultrasonication is also useful for forming crystals of proteins. We address the underlying mechanism of the ultrasonication-dependent breakdown of supersaturation, leading to the formation of amyloid fibrils or protein crystals.
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