Seibutsu Butsuri
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
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Volume 55, Issue 3
Issue 319
Displaying 1-19 of 19 articles from this issue
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Perspective
Overview
  • Regulatory Mechanism of Cytoplasmic Dynein
    Takayuki TORISAWA, Ken’ya FURUTA, Yoko Y. TOYOSHIMA
    2015 Volume 55 Issue 3 Pages 127-132
    Published: 2015
    Released on J-STAGE: May 30, 2015
    DOIhttps://doi.org/10.2142/biophys.55.127
    JOURNAL FREE ACCESS
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    Cytoplasmic dynein is a minus-end-directed microtubule-based motor involving various cellular functions including intracellular transport, cell division, and neuronal migration. Recent studies have revealed that single molecules of cytoplasmic dynein do not display unidirectional movement as observed in intracellular transport, but diffuse along microtubules. This diffusive behavior is transitioned to the unidirectional movement via regulatory protein mediated mechanism or self-regulated mechanism. Here, we review the recent advances in the study of cytoplasmic dynein regulation.
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Review
  • Refinement of Amino Acid Substitution Matrix for Detecting Distant Relationships of Proteins
    Kazunori YAMADA, Kentaro TOMII
    2015 Volume 55 Issue 3 Pages 133-136
    Published: 2015
    Released on J-STAGE: May 30, 2015
    DOIhttps://doi.org/10.2142/biophys.55.133
    JOURNAL FREE ACCESS
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    Amino acid similarity search methods are fundamental tools for inferring protein structure and function. Optimization of amino acid substitution matrices is indispensable to improve search performance. We explored matrices that are ideal for detecting distantly related proteins in the PCA subspace that represents a set of typical existing matrices, and derived a novel sensitive matrix: MIQS. Test results show that the MIQS detection performance is superior to those of existing matrices and other sequence comparison methods. This refinement of the amino acid substitution matrix might influence many fields of sequence analysis. MIQS is available at http://csas.cbrc.jp/Ssearch/.
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  • Molecular Basis of DNA Quality Control for Mammalian Nucleotide Excision Repair
    Masaki AKITA, Kaoru SUGASAWA
    2015 Volume 55 Issue 3 Pages 137-141
    Published: 2015
    Released on J-STAGE: May 30, 2015
    DOIhttps://doi.org/10.2142/biophys.55.137
    JOURNAL FREE ACCESS
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    For organisms, a fundamental problem is how the huge genome can be searched appropriately for DNA damage in order to prevent genome instability and/or cell death. In mammalian nucleotide excision repair (NER), this process involves multiple protein factors containing the xeroderma pigmentosum gene products (UV-DDB, XPC, TFIIH), which sense different aspects of DNA structural abnormalities, respectively. Coordinated stepwise actions of these factors contribute to simultaneous achievement of versatility, efficiency and accuracy of the DNA quality control for NER.
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Topics
Topics (Young Scientist Series)
Theoretical and experimental techniques
Activity of Regional Branch
Young Voice
Letters from Abroad
Promenade along Protein 3D Structures
Book Review
Technical term
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