生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
58 巻 , 1 号
通巻335号
選択された号の論文の14件中1~14を表示しています
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  • 炭竈 享司, 老木 成稔
    2018 年 58 巻 1 号 p. 012-016
    発行日: 2018年
    公開日: 2018/01/30
    ジャーナル フリー

    Ion permeation through ion channels is essential for life. Since the determination of the x-ray crystal structure of the K+ channel, extensive molecular dynamics (MD) studies have been performed to visualize ion permeation through the channel. However, the mechanism underlying how the experimentally measured current amplitudes are determined still remains elusive. Here, we examined the MD-simulated trajectories of ion permeation through the Kv1.2 channel by developing a method analyzing the dynamics of ions. The analysis clarified that the entrance of ions into the channel determines the permeation rate.

  • 岩田 想, 南後 恵理子
    2018 年 58 巻 1 号 p. 017-021
    発行日: 2018年
    公開日: 2018/01/30
    ジャーナル フリー

    At SACLA, we are developing a data collection system focusing on dynamic crystallography putting a particular effort on membrane proteins. An experimental system for pump-probe experiments based on serial femtosecond crystallography using a viscous material injector has been developed. We used time-resolved serial femtosecond crystallography to visualize conformational changes in bR from nanoseconds to milliseconds following photoactivation. The cascade of structural changes throughout the protein shows how motions are choreographed as bR transports protons. We have also applied this system to study the light-induced structural changes and the site of O=O bond formation in photosystem II.

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