生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
58 巻 , 6 号
通巻340号
選択された号の論文の14件中1~14を表示しています
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  • 伏見 圭司, 成川 礼
    2018 年 58 巻 6 号 p. 303-307
    発行日: 2018年
    公開日: 2018/11/27
    ジャーナル フリー

    Because light is not only energy source but also important signal for photosynthetic organisms, these organisms develop highly organized light acclimation processes. Linear tetrapyrrole-binding photoreceptors play central roles in these processes. They are categorized into phytochrome and cyanobacteriochrome families. Here, we summarize current knowledge on these photoreceptor families especially focusing on color-tuning mechanisms of the cyanobacteriochromes. Because these photoreceptors possess many advantages for optogenetic and bio-imaging applications, we briefly introduce current developmental status of these photoreceptors.

  • 佐藤 守俊
    2018 年 58 巻 6 号 p. 308-312
    発行日: 2018年
    公開日: 2018/11/27
    ジャーナル フリー

    Complex gene networks are essential for diverse biological phenomena, such as cellular programming, metabolism, homeostasis, memory formation, and circadian rhythm. To understand these biological phenomena, including diseases, and to utilize or modify them, approaches that enable optical control of the genome are required. We developed new tools for targeted gene manipulation based on optical control of the CRISPR-Cas9 system and Cre-loxP system. These tools could greatly facilitate understanding of a variety of gene functions and prove useful in biomedical applications. Genome engineering technology and optogenetics technology have emerged as different technologies from each other so far. Our studies merge these emerging research fields together.

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