生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
最新号
通巻343号
選択された号の論文の16件中1~16を表示しています
巻頭言
解説
  • 山本 条太郎, 北村 朗, 金城 政孝
    2019 年 59 巻 3 号 p. 125-131
    発行日: 2019年
    公開日: 2019/05/25
    ジャーナル フリー

    Fluorescence correlation spectroscopy (FCS) is a potential tool to measure the dynamics of fluorescent molecules, either in solution or in a cell. FCS can quantify the diffusion coefficient, the target molecule concentration, and brightness of a single molecule. These parameters allow estimations of the molecular size, the molecular shape, and the affinities of molecular interactions. Moreover, varieties of FCS methods have been developed on the concept of the fluorescence lifetime, triplet state, decrease of fluorescent intensity and toward two-dimensional imaging, in order to reveal the molecular interaction in live cell and molecular crowding.

総説
  • 佐藤 恵太, 山下 高廣, 大内 淑代, 七田 芳則
    2019 年 59 巻 3 号 p. 132-136
    発行日: 2019年
    公開日: 2019/05/25
    ジャーナル フリー

    Opsins are animal photoreceptor proteins that use retinal as their chromophore (ligand) and are classified into several groups based on sequence similarity. Opn5 forms one phylogenetically separate opsin group and includes three vertebrate-specific subgroups, Opn5m, Opn5L1 and Opn5L2. In this article, we introduce highly diversified functionalities of vertebrate Opn5. Three Opn5 subgroups show characteristic spectral sensitivity, preference for retinal isomers and photoreaction process, and work as bistable photoreceptor, retinal chemoreceptor or unidirectional photoreceptor. Such broad spectrum of functionalities may be attributed to optimization for respective physiological functions.

  • 田口 英樹, 茶谷 悠平, 丹羽 達也
    2019 年 59 巻 3 号 p. 137-140
    発行日: 2019年
    公開日: 2019/05/25
    ジャーナル フリー

    Proteins do not instantaneously finish the synthesis and folding into functioning products, but experience the nascent peptidyl-tRNAs, defined as “nascent chains”, during the translation. So far, nascent chains are regarded as transient intermediates during the protein synthesis. However, recent advances have revealed that nascent chains are directly involved in a variety of cellular processes including self-maturation and the quality control system of protein and mRNA. In this review, we summarize recent progress on noncanonical translation dynamics and co-translational folding.

トピックス
トピックス(新進気鋭シリーズ)
理論/実験 技術
談話室
支部だより
若手の会だより
海外だより
用語解説
feedback
Top