First of all, the free sugars in pus from the gingival pockets of periodontitis, and pus of alveolar and gingival abscess were observed by paperchromatography. Secondly, the relation between total weight, glucose content in pus and exudate from gingival pockets and the severity of periodontitis, the pocket depth, sex and age was quantitatively analyzed. Furthermore, the effect of blood sugar level upon the glucose concentration in gingival pocket fluid of periodontitis associated with diabetes mellitus was examined. As the results, glucose spot was detected in all cases of periodontitis, alveolar and gingival abscess. Besides glucose, ribose and desoxyribose spots also were found in some cases of involvement mentioned above.
The amount of pus was proportional to the severity of periodontitis and an increase of pocket depth. In addition, the weight of exudate was more increased in periodontitis than in clinically healthy gingiva. A characteristic finding was not obtained from sex and age differences. In glucose concentration per 1mg of gingival pocket fluid it was found that in clinically healthy gingiva it was approximately equal to the blood sugar level of healthy person (70-110 mg%) and it was increased slightly in periodontitis than in clinically healthy gingiva. And in periodontitis the tendency to decrease gradually proportionally to the severity of inflammation was shown. In the cases of periodontitis involving diabetes with hyperglycemia glucose content in gingival pocket fluid was increased, as the blood sugar level was increased. It is pointed out that an increase of glucose consumption in gingival tissue may be related to an increased severity of diabetes. Finally, there was a close correlation between the glucose concentration per 1 mg of pus and that of exudate in the same patient of periodontitis. This finding is regarded as evidence that tissue fluid may always exude through the gingival pocket epithelial layer into the gingival pocket.
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