The present investigation was undertaken to study the carbohydrate metabolism of the mesencephalic nucleus of the trigeminal nerve in detail: The latest histochemical methods were applied to the rat brain. The nerve cells of the nucleus showed variable reactions in their cytoplasm for enzymes: The reactions were moderate through the modified Takeuchi-Kuriaki method; either strong or negative through Friede’s method for amylophosphorylase; moderate or strong for aldolase, succinate dehydrogenase and cytochrome oxiclase; weak or moderate for glucose-6-phosphate dehydrogenase and weak for 6-phosphogluconate dehydrogenase. The neuropile showed weak or moderate reactions through the modified Takeuchi-Kuriaki method. It exhibited the slight reactions for aldolase, and for glucose-6-phosphate, 6-phosphogluconate and succinate dehydrogenases as well as the weak reaction for cytochrome oxidase. Some satellite cells showed strong amylophosphorylase reactions through Friede’s method, moderate ones through the modified Takeuchi-Kuriaki method, and moderate aldolase reactions, while the reactions for succinate dehydrogenase and cytochrome oxidase appeared to be weak. Weak reactions were observed in the nuclei of the nerve cells for these enzymes. There was no perinuclear concentration of succinate dehydrogenase or of cytochrome oxidase.

抄録全体を表示

The present studies provide an evidence suggesting that the occurrence of acid agglutination is one of the remarkable characteristics of the fimbriate strains of E. coli, Sh. flexneri or S. marcescens, and that the fimbriae may significantly influence the net charge of the bacterial surface. Three types of pattern of acid agglutination are recognizable and may be interpreted as presenting the qualitative and quantitative differences in the constituents of the fimbriae or in the antigenic structure.

抄録全体を表示

It has been reported that the stimulating effect of insulin-induced hypoglycemia influencing the gastric secretion passes through two pathways, the vagus and the hypothalamic-pituitary-adrenal system. Gastric analysis by insulin hypoglycemia was performed in an attempt to obtain an acid secretory pattern for gastric and duodenal ulcers. Insulin used was 10 units of Novo regular insulin. In duodenal ulcer, nearly the same data as reported by Stempien and his associates were obtained. In gastric ulcer, however, many cases showed delayed gastric secretion, which was described to be due to hypothalamic-pituitary-adrenal system, as compared to the patterns in duodenal ulcer and normal healthy control. This suggested that the hypothalamic-pituitary-adrenal system played an important role in the etiology of gastric ulcer. It was suggested that the increased excitation of two regulating mechanisms, the vagal center and the hypothalamic-pituitary-adrenal system, acted as the principal role in the etiology of duodenal ulcer.

抄録全体を表示

One hundred seventy four gastric cancer patients admitted to our department from 1956 to 1959. The cases surviving over 5 years were 19 patients and the 5-year survival rate in our department was 26.0%. It is not satisfactory to us considering the up-to-date progress in medical science. Between CAT., SAT., and INF. of the new Japanese classification on gastric carcinoma and prognosis, there is found a remarkable correlotion by this survey. Also, there is a close relation between prognosis and lymphnode conditions during operation, carcinoma infiltration state into the stomach wall. We should have many data before the operation to consider and compare with the post-operation data.

抄録全体を表示

First of all, the free sugars in pus from the gingival pockets of periodontitis, and pus of alveolar and gingival abscess were observed by paperchromatography. Secondly, the relation between total weight, glucose content in pus and exudate from gingival pockets and the severity of periodontitis, the pocket depth, sex and age was quantitatively analyzed. Furthermore, the effect of blood sugar level upon the glucose concentration in gingival pocket fluid of periodontitis associated with diabetes mellitus was examined. As the results, glucose spot was detected in all cases of periodontitis, alveolar and gingival abscess. Besides glucose, ribose and desoxyribose spots also were found in some cases of involvement mentioned above. The amount of pus was proportional to the severity of periodontitis and an increase of pocket depth. In addition, the weight of exudate was more increased in periodontitis than in clinically healthy gingiva. A characteristic finding was not obtained from sex and age differences. In glucose concentration per 1mg of gingival pocket fluid it was found that in clinically healthy gingiva it was approximately equal to the blood sugar level of healthy person (70-110 mg%) and it was increased slightly in periodontitis than in clinically healthy gingiva. And in periodontitis the tendency to decrease gradually proportionally to the severity of inflammation was shown. In the cases of periodontitis involving diabetes with hyperglycemia glucose content in gingival pocket fluid was increased, as the blood sugar level was increased. It is pointed out that an increase of glucose consumption in gingival tissue may be related to an increased severity of diabetes. Finally, there was a close correlation between the glucose concentration per 1 mg of pus and that of exudate in the same patient of periodontitis. This finding is regarded as evidence that tissue fluid may always exude through the gingival pocket epithelial layer into the gingival pocket.

抄録全体を表示