Rats into which Yoshida sarcoma ceils had been inoculated were treated by radiation and/or carcinostatic agents.
Then, Yoshida-sarcoma cells obtained from the rats were transplanted to normal rats.
Then therapeutic effect of the radiation and/ or carcinostatic agents was evaluated by mean survival days of the latter rats.
Although epipharyngitis shows few local symptoms, the inflammation is severe and connected with overall body symptoms. This is bionomical and pathological specificity of epipharyngitis. The pathology of epipharyngitis was investigated and the correlation to the fibrinolytic system by observing the clinical course of epipharyngitis and the fibrinolytic activity. After a long· term observation a close relationship between them was found.
As far as our present knowledge regarding food poisoning in Japan it appears probably that Vibrio parahaemolyticus was the etiological agent in many of the outbreaks in which no definite evidence was available. However full information on the preventive measures against food poisoning is still lacking. This is because it is closely related to the peculiar etiology of Vibrio parahaemolyticus. Various experiments on this work have shown the following results: Vibrio parahaemolyticus could be killed if heated in peptone solution at 55°C for 10 minutes or at 60°C for 5 minutes. Further, resistance of the bacteria to other physical environmental factors in relative low temperature, freezing and drying condition was ascertained to be generally weak, although influenced by the bacterial counts, the length of time during which the bacteria were exposed to them and so on. The organisms of Vibrio parahaemolyticus were also killed in distilled water in a short period of time. Consequently, outbreaks can be prevented by washing seafish sufficiently in fresh water, or in boiling water if possible. It is likewise effective for this purpose to keep seafish and fish products cold, as well as to cook them by heating. Drying of utensils as sources of secondary contamination is recommended.
Microscopic and submicroscopic observations were performed in an attempt to know the patho- and morphogenesis of arteriolar hyalinosis of the human testis. Testicles of 238 autopsy cases of acute death in Tokyo Medical Examiner’s Office, 159 autopsied hospital cases and 150 biopsy materials of various morbid origins were examined. The results obtained are summarized as follows: 1. Hyalinotic lesions of the testicular arterioles appear with the beginning of puberty and reach the maximum at the third decade in severity and frequency. On the other hand, focal scarring process with elastofibrosis concurrs within hyaline deposition and the scarred foci increase in number with aging. 2. Almost all testes of the adults are more or less involved in the vascular hyalinosis. 3. Hyaline impregnation begins in the subendothelial layer, most probably as a result of the enhanced transcellular permeability of the endothelium. i.e. cytopempsis or pinocytosis. 4. Hyaline deposits are mainly composed of granular glycolipoprotein originated from the imported plasmatic fluids and from the secondarily disintegrated basement membrane and elastic lammellae. 5. It may be supposed that through pino- or phagocytosis smooth muscle cells play more or less an active role in removal of hyaline deposition. 6. Pathogenesis of the hyalinosis is far from being understood completely. It may be assumed that hemodynamic alteration in response to functional maturation and activation of the testis is closely connected with the manifestation of the lesions.
The vascular system in the rat lower incisor and the process of its development were examined in cleared specimens of various ages of postnatal growth, and the following results were obtained. Arteries leading to the lower incisor come chiefly from the lingual side and connect with a regular capillary network lying buried in the external surface of the outer enamel epithelium. The capillaries flow together along the lateral border of the enarr el organ, to join a rich venous plexus surrounding the incisor bud. The efferent veins arising from the plexus connect with the pterygoid plexus and anterior facial vein. With the progress of postnatal growth, the capillary network in the outer enamel epithelium comes to show a distinct regularity, while the venous plexus surrounding the capillaries from the outside extends widely to enclose the enamel organ and the posterior two-thirds of the incisor. In addition to these descriptions, some discussions are made on the functional significance of the capillary network and the venous plexus.