THE BULLETIN OF TOKYO MEDICAL AND DENTAL UNIVERSITY
Online ISSN : 2435-0761
Print ISSN : 0040-8921
16 巻, 4 号
選択された号の論文の7件中1~7を表示しています
  • Sho MATSUBARA
    1969 年 16 巻 4 号 p. 261-288
    発行日: 1969年
    公開日: 2022/11/23
    ジャーナル オープンアクセス
    The dose-response relationship of the chromosomal damage to the blood lymphocytes was obtained from the in vitro experiment, and an attempt of its use was made to evaluate possible clinical meanings of the chromosomal damages to the lymphocytes in patients given radiation therapy for malignant diseases. In the patients given single dose of gamma-ray exposure, the chromosome analysis of the circulating lymphocytes showed that the production of chromosome aberrations in the irradiated region was grossly analogous to that of the in vitro exposure and that the overall frequency of the chromosome aberrations was determined by the irradiated volume, body weight and radiation dose. After repeated doses of therapeutic radiation, it was found that the irradiated volume, body weight and radiation dose were also among the important factors influencing the level of chromosome aberrations in the circulating lymphocytes. From the data obtained, other factors such as loss of lymphocytes due to death and recovery of the lymphocyte system were shown to play an important part in the determination of the level of chromosome aberrations in the blood lymphocytes, especially in the long term fractionated radiation therapy.
  • Kiyoshi KISHI
    1969 年 16 巻 4 号 p. 289-302
    発行日: 1969年
    公開日: 2022/11/23
    ジャーナル オープンアクセス
    A method for the demonstration of the activity of purine nucleoside phosphorylase in the tissues is described. In the histochemical system, the enzyme converted the substrate inosine to hypoxanthine. The resulting hypoxanthine was oxidized by exogeneous and endogeneous xanthine oxidase to uric acid, whereby the xanthine oxidase reduced Nitro BT to insoluble formazan. The specificity of the method is discussed in this study. In addition, the distribution of the purine nucleoside phosphorylase activity in the various tissues of rats is described. High activities were found in the liver cells, reticular cells of spleen, and oocytes of ovary. Moderate activities were found in the epithelium of the choroid plexus, reticular cells of the thymus, epithelium of the bronchiole, cells of the alveolar wall, parietal cells of the gastric gland, proximal tubules of the kidney, interstitial cells of the ovary, and epithelium of the ductus epididymidis. The cardiac muscle, small intestine, and pancreas were inactive. All the activities were found in the cytoplasm and not in the nucleus.
  • Kunio KOHNO
    1969 年 16 巻 4 号 p. 303-309
    発行日: 1969年
    公開日: 2022/11/23
    ジャーナル オープンアクセス
    Gliosomes, though small in number, have been found in the satellite cells of the spinal ganglia of the frog, Rana nigromaculata nigromaculata. Possibly the longest one of them is more than 17 µ in length and about 0.8 µ in width, and the cross-section may show a rhomboidal profile. Its matrix except for only a small peripheral region where prismatic tubules are aligned in a row, is occupied by a bundle of numerous longitudinally arranged filaments, about 60 A thick, with a periodic cross-striation of about 120 A wide.
  • Nobuhiro KAWAMURA
    1969 年 16 巻 4 号 p. 311-325
    発行日: 1969年
    公開日: 2022/11/23
    ジャーナル オープンアクセス
    Antigenicity of the epithelial cells of human thyroid glands of 50 patients, consisting of 13 cases of hyperthyroidism, 6 cases of chronic thyroiditis, 23 cases of benign thyroid tumor, and 8 cases of thyroid cancer, were examined by the fluorescent antibody technique with antithyroid γ-globulin prepared from the serum of a patient with Graves’ disease, and identified as a specific antibody against microsomal fraction of follicular epithelial cells. All the epithelial cells of the toxic thyroid gland contained the microsomal antigen, which was commonly detected in the epithelial cells of normal thyroid tissues. The former exhibited more brilliant fluorescent staining than the latter. Six cases of hyperthyroidism showed a brighter fluorescent zone adjacent to the free surface of the epithelial cells. The epithelial cells of chronic thyroiditis contained the microsomal antigen common to the normal and toxic thyroid glands, the fluorescent staining of which varied in degree, depending on cytological destruction. In benign thyroid tumors, the microsomal antigen commonly observed in the normal and toxic thyroid gland survived, although it was lost in the descending order of colloid adenoma, simple adenoma, and fetal adenoma. The epithelial cells of both follicular and papillary adenocarcinoma of the thyroid lost the microsomal antigen of the normal follicular epithelial cells, even though they were well differentiated.
  • Atsushi IGARASHI
    1969 年 16 巻 4 号 p. 327-341
    発行日: 1969年
    公開日: 2022/11/23
    ジャーナル オープンアクセス
    When the Ama, professional female breath hold divers of Japan, begin their work just at the opening of the harvest season or when they recommence their work after a certain period of interruption due to bad weather or illness, they complain the difficulty of breathing and lowering of diving efficiency. However, after several days from the beginning of diving, they say that they can dive much easier. This phenomenon suggests the building up of an adaptation to the breath-hold diving. In order to explain the mechanism of this phenomenon, the following experiments were carried out: 1) The ventilatory responses to CO2 of eight active Ama were measured, (a) just after the closing of the harvest season, (b) three months later, and (c) six months after the closing period, i.e. just before the opening period. As a result, it was found that the repeated breath hold diving would lower the sensitivity of the respiratory center to CO2. 2) To ascertain this phenomenon experimentally, three male subjects without the experience of diving were loaded by bicycle ergometer exercises and a series of repeated breath-holding for one hour per day, 7 days continuously. Before, during, and after this experiment period, sensitivity of the respiratory center to CO2 was measured at each period, and it was found that this sensitivity decreased significantly with lapse of time. Therefore, this phenomenon is an adaptation favorable for the Ama, and to avoid the low diving efficiency at the beginning of the diving season, it would be practical to repeat breath -hold exercise for several days before they recommence their diving work.
  • Ryohei OKAMOTO, Kyoichi ASHIKAGA, Haruhisa OHTSUKA
    1969 年 16 巻 4 号 p. 343-349
    発行日: 1969年
    公開日: 2022/11/23
    ジャーナル オープンアクセス
    Biological, chemical, or immunological properties of prolactin are not yet completely understood. The relationship between pituitary prolactin and growth hormone or prolactin-like substance in the fluids such as blood and urine in human is another important problem to study. The relationship between pituitary prolactin and growth hormone or prolactin-like substance in the fluids such as blood and urine in human is another important problem to study. In the present experiment isolation of prolactin from the rat pituitary tissue culture medium was attempted by acrylamide gel electrophoresis, utilizing the fact that the pituitary separated from hypothalamic connection secreted almost exclusively prolactin and that pituitary prolactin increased by estrogen administration. As a result of 7-day culture prolactin band was obtained separately. Presence of growth hormone band even after 7-day culture indicated existence of GIF (growth hormone-inhibiting factor) in the hypothalamus.
  • Hiroichi IKEDA
    1969 年 16 巻 4 号 p. 351-365
    発行日: 1969年
    公開日: 2022/11/23
    ジャーナル オープンアクセス
    The standard dental gold alloy is a 20-carat alloy, but lower carat alloys are also used. In Japan, 14-carat gold alloy3 are still used often in actual practice but from the point of not only resistance to tarnish and corrosion but also from the point of the mechanical properties these have been recognized generally not being sufficient as a dental alloy. Consequently, the question naturally arises as to whether there is a good dental alloy which has a gold content intermediate of the two alloys mentioned above. However, contrary to our expectation there are few studies on this problem. Therefore studies were made on the composition and the significant properties of the Au-Ag-Cu-Zn system 16-carat dental gold alloys and on the practical use of these alloys. In addition, studies were made on the effect of heat treatment. As a result, it was found that the composition of the 16-carat alloys is 66.7% of Au, 18-10% of Ag, 5-2 % of Zn and Cu composing the rest, having on the average a fairly good property.
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