This report is thought to be the first documented case of Klippel-Trenaunay syndrome complicated with omental hemorrhage with symptoms of acute abdomen. This 6-year-old Japanese girl was successfully treated by the extirpation of omental hemangioma in an emergency laparotomy. The association of the varicose vein, soft tissue and bony hypertrophy, and cutaneous hemagioma of the “port-wine” variety, confined to one extremity, was first described in 1900 by Klippel and Trenaunay1). After reporting three additional cases in 19072), Parkes-Weber3) described a second entity which appears to be similar to the Klippel-Trenaunay triad, with the addition of an arteriovenous fistula. Subsequently, there has been much confusion regarding both Klippel-Trenaunay and Parkes-Weber syndromes. Mullins4) described the syndrome as a Klippel-Trenaunay­Weber syndrome and gave the name of “Naevus vasculosus osteohypertrophicus” to it. In 1965, Lindenauer5) reported an excellent survey on the syndrome, and advocated the separation of the Klippel-Trenaunay syndrome from the Parkes-Weber syndrome, because this differentiation is meaningful, both in terms of etiology and management. Many cases of the two entities were reported in the world. Three cases of the syndrome in Japan were first reported in 1927 by Tashiro6). Subsequently, many cases were reported and an excellent survey of 96 cases reported in Japan was made in 1966 by Fujisawa et al.7) The purpose of this paper is to report a Klippel-Trenaunay syndrome complicated with omental hemangioma with acute hemorrhage and with symptoms of acute abdomen.

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Correlation between self-perpetuation of hepatitis and autoimmune phenomenon still remains obscure. Recently, attention has been drawn to the fact that blastoid cell transformation occurs with the addition of phytohemagglutinin when culturing human lymphocytes. Using lymphocytes taken from 55 patients with chronic liver diseases, which were cultured with a medium containing autologous liver homogenate obtained by needle biopsy, the occurrence of blastoid cell transformation was studied. Blastoid cell transformation was demonstrated in about one-third of the patients. The transformation rate, ranging from 0.2% to 7.4%, was lower than that of lymphocyte cultures to which phytohemagglutinin was added. But no evidence of blastoid cells was found in the patients without liver diseases. As compared to those with a negative response, the values of GOT, GPT and BSP were significantly elevated in the patients with a positive response and, histologically, marked infiltration of small lymphocytes and necrosis of liver cells were observed. Furthermore, a tendency toward poor prognosis was shown by many patients with a positive response. In patients with a positive blastoid cell response, positive rheumatoid serologic findings were also present significantly, indicating a close correlation between the two. The above observations suggest that the lymphocytes, sensitized by the patient’s own liver, play a certain part in the mechanism of self-perpetuation of hepatitis.

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An underwear made of a stretchable knitted fabric fits tightly on the skin when worn. Care must be taken of the amount of clothing pressure caused by the tight-fitting cloth, and its psychological and physiological effects on the wearer. There seemed to be correlations among the deformation of an underwear when it is in use, clothing pressure, physiological disturbance (disturbance of blood flow), and bodily comfort (psychological restraining sensation), and the following results were experimentally obtained: 1) As a result of computation of correlation between respective two out of clothing pressure, disturbance of blood flow, and psychological sensation around the elbow joint, it has been found that each of the respective two has a close correlation. In particular, that between a clothing pressure, P, and an amplitude, Va, of pulse wave through the plethysmograph, may be expressed by the following equation: P = 313 - 95Va 2) By applying the above relation to the clothing pressure of an underwear, it has been estimated that the effect of a clothing pressure on the elbow joint reduces the amplitude of pulse wave by 80%. In reality, however, it seems that the clothing pressure of an underwear will not have such a great effect on a human beings, because the clothing pressure on the internal part of an elbow joint is lower than that of its outer part.

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The present study reports on the functional and morphological changes in the ovaries in relation to the bioassay findings in this organ. 1) HMG (Humegon, Sankyo-Organon) treatment induced maturation of the primordial follicles to the mature follicles. Increased doses of more than 2 IU of HMG also caused formation of corpus luteum. 2) Following treatment with HMG+anti-HCG serum, the LH activity was suppressed. Histologically maturation of the follicles were demonstrable but the corpus luteum formation was not seen. 3) G-6-PDH and 3β-olDH activities were demonstrated in the granulosa, corpora lutea, theca interna and the interstitial cells. 4) Electron microscopic studies: (a) Granulosa cells: Mitochondria with villous cristae and vesicle like endoplasmic reticulum were seen. (b) Theca interna: The characteristic morphological findings were oblong-shaped mitochondria and endoplasmic reticulum. Deposits of fat granules were seen in the blind ends of the endoplasmic reticulum. (c) Lutein cells: The lutein cells were oval in shape and contained vesicular cristae and mitochondria. They were mostly of the smooth endoplasmic reticulum.

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Experimental skin calcification caused by intravenous injection of lead acetate followed by subcutaneous injection of polymyxin in the rat was studied primarily by the methods of quantitative chemical analysis. It was found that the degree of calcification could generally be estimated by measuring the area or the weight or the amount of minerals in the calcified tissues. The total amount of calcium, however, increased significantly, though the area, dry weight, and total amount of phosphorus of the calcified tissues did not show significant increase between 1O and 2O days after injections of lead acetate and polymyxin. The degree of calcification was greatest when the time interval between the two injections was the shortest, while the levels of serum calcium and phosphorus, in contrast, reached their peaks about 2 hours after intravenous injection of lead acetate. It seems that the amount of lead deposited in the calcified tissues is closely related to the initial stage of calcification. Lead was detected in the calcified tissues even as long as 2O days after the injections of lead acetate and polymyxin.

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