THE BULLETIN OF TOKYO MEDICAL AND DENTAL UNIVERSITY
Online ISSN : 2435-0761
Print ISSN : 0040-8921
Volume 32 , Issue 3
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  • Masahiro UMINO, Masaaki MIURA, Takahiko KONDO, Kumiko OHI, Atsuko YOSH ...
    1985 Volume 32 Issue 3 Pages 91-96
    Published: 1985
    Released: December 15, 2019
    JOURNALS OPEN ACCESS
    The effects of thiamylal and diazepam on the release of myoglobin and creatine phosphokinase following the administration of succinylcholine chloride during halothane anesthesia were studied. Thirty patients receiving halothane anesthesia were divided into three groups. In Group I, 1.5-2 mg/kg of thiamylal were given intravenously as pretreatment before the injection of succinylcholine chloride. In Group II, 0.3 mg/kg of diazepam were given and, in Group III, only succinylcholine chloride was injected. A significant increase in the serum myoglobin and creatine phosphokinase levels was observed in all groups. However, the values in Group I were significantly lower than those in Groups II and III and a significant difference was not detected between Group II and Ill. Our results indicate that thiamylal has a considerable inhibitory effect on the release of myoglobin and creatine phosphokinase from the muscle following the administration of succinylcholine chloride.
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