The results of 25 percutaneous biopsies of the liver from 24 patients with non-Hodgkin’s lymphoma are reported. In all cases, the value of their serum biochemistry (LDH, GOT, GPT and/or alkaline phosphatase) was abnormal and sufficient tissue material was biopsied to obtain a histopathological evaluation.
Specimens from five ultrasonically suspected lymphoma of the liver showed tumor involvement histopathologically. Diffuse tumor involvement was also histologically found in three ultrasonically unsuspected livers. Six liver specimens showed degenerative and/or fibrotic change in the new and previously treated patients.
The technique “asymmetric biphasic stimulation” which paces the heart and neutralizes the post-stimulus polarization at the electrode-tiessue interface allows for the recording of the entire evoked endocardial response via a single electrode for both pacing and recording. Using this system the effects of antiarrhythmic drugs, procainamide and N-acetylprocainamide, on the myocardium were studied in 20 dogs. Before and during the five step drug infusion, the evoked endocardial responses were recorded during bipolar and unipolar at the rates of 120, 150 and 200/min. The plasma concentration of the procainamede ranged from 1.7 to 32.5 mg/l and that of N-acetylprocainamide ranged from 8.1 to 116.l mg/l. Procainamied significantly prolonged both the depolarization duration and the repolarization duration at a low plasma concentration (Class I antiarrhythmic drug property). N-acetylprocainamide significantly prolonged the repolarization duration at a low plasma concentration, while the depolarization duration was not significantly changed at a low or therapeutic plasma concentration (Class III antiarrhythmic drug property). The prolongacion of the depolarization duration by procainamide and N-acetylprocainamide was rate-dependent; the faster the rate the greater the prolongation. This simple and accurate assessment of the antiarrhythmic drug effects on the myocardium may provie a future means for the pharmacologic antiarrhythmic therapy.
In order to find out whether there is a change in depression itself besides the increase of depression, we made a research by two methods. The first method is what we can call a statistical method, and here we made a comparative examination of the symptoms of depression having different sociocultural backgrounds by examining 114 cases of depression in Tokyo and 108 in Nagasaki. By the second method we divided the 24 cases of depression in Tokyo into two groups, “partients grown up during the prewar period” and “patients grown up during the postwar period”, according to the date of their birth, and analyzed the precipitating factors (life events) of depression and psychopathology. As a result, we can infer that while the depression in Tokyo is of an urban type, the depression in Nagasaki is of a classical type, and as for the life events, “patients grown up during the prewar period” tend to be involved in the family/household and social network events whereas “patients grown up during the postwar period” tend to be involved in the personal and livelihood events, and here we can observe a significant statistical difference between the two groups. Furthermore, we found out that the life events of the “patients grown up during the postwar period” were limited to the personal interests and that they rarely suffered from self-reproach or feeling of guilt.
Forty-seven patients with gastrointestinal bleeding, benign tumor and malignancy were treated by YAG-laser therapy from 1980 to 1987. For active bleeding, laser coagulation was effective in inducing hemostasis. This therapy was also effective for the potential bleeding lesions. Benign sessile lesions such as polyp and adenoma were completely treated by laser vaporization. In cases with malignancy, the small-sized early gastric cancer (less than 15 mm in diameter) could be effectively treated. Among them, one case was followed up for as long as 82 months without any sign of recurrence. On the other hand, poor results were obtained in the cases suffering from early esophageal cancer due to incomplete laser irradiation resulting from the fear of penetration through the thin-walled esophageal mucosa. However, for the malignant stricture, the laser therapy was useful to relieve the lesion due to the regression of the tumor size. After the treatment, the patient was able to take meals orally. The above data demonstrate that the laser therapy is useful for the treatment of bleeding, sessile lesions, small-sized early gastric cancers and malignant strictures induced by advanced cancer.
The relationship between the amplitude of somatosensory evoked potentials (SEP) and the subjective pain estimation using a visual analogue scale (VAS) was exmained in 8 volunteers undergoing randomized electrical tooth stimulation with 3 different intensities. Randomized stimulation was used instead of repetitive stimulation with a fixed intensity in order to minimize the phenomena of habituation and expectancy in recording the SEP and VAS. The VAS scores increased significantly with the stimulus intensity. The amplitude with a latency between 160 and 300 msec (N 160-P300) showed a significant increase with the increased intensity. But the amplitudes between 60 and 110 msec (N60-P 110) and between 110 and 160 msec (P110-N 160) showed no significant change. There was a significant correlation between the amplitude of N 160-P300 and the VAS scores.
These findings indicate that the component between 160 and 300 msec reflects the perceived pain intensity and the psychological evaluation processes such as cognition, meaning, interpretation and appreciation of pain. The method of randomized stimulation can serve as a simple and useful way for the objective or subjective pain estimation.
The incidence of Rh anti-E antibody production due to blood transfusion in the patients who were Rh E negative and were transfused with more than one unit (200 ml) of E positive red blood cells was examined. The anti-E was detected in 17 (4.7%) out of 360 patients. The incidence of anti-E was significantly higher in the patients who had previously received transfusion than in those who had not. By a similar method, the anti-c was detected in 4 (1.4%) out of 284 patients. The incidence of anti-E and anti-c production among the Japanese receiving blood transfusion at random is estimated to be 1.17% and 0.35%, respectively.