A case of chronic lymphocytic leukemia was reported which was characterized by cells with a presumptive A
1/G translocation, and an extremely high serum γ-globulin content. It was shown in the blood culture that, under the influence of phytohemagglutinin, mitosis of non-leukemic lymphocytes became predominant over that of leukemic lymphocytes with the A
1/G translocation, while A
1/G cells comprised one-half of the metaphase population grown without phytohemagglutinin. At least three kinds of lymphocytes were present; leukemic lymphocytes with or without the A
1/G translocation dividing
in vitro without phytohemagglutinin, and normal lymphocytes proliferating only under phytohemagglutinin stimulation.
The amount of serum γ-globulin was extremely high in this patient. Analyses by immunoelectrophoresis and immunoplate revealed a striking increase of IgG. It is not clear in the present case whether or not the A
1/G cells are related to the elevated production of γ-globulin.
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