It has recently been reported that the accumulation of amyloid β(Aβ)peptides in the human lens may be related to the onset of lens opacification, but this mechanism of Aβ accumulation is not fully understood. In this study, we investigated the changes in gene expression levels for proteins related to Aβ production(APP, BACE1 and PS)and degradation(ADAM10, NEP, ECE-1)in the lens epithelium of patient with or without dementia. The Aβ mRNA expression was determined by real-time PCR method, and samples were collected from Japanese patients taken during cataract surgery. The NEP and ECE-1 mRNA levels in the cataractous lenses of patients with dementia were significantly lower than that in patients without dementia. In conclusion, we found low levels of gene expression for proteins related to Aβ degradation in the lens epithelium of Japanese patients with dementia.
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