心拍動下バイパス術(OPCAB)中100回/分以上の上室性頻脈を呈した20例を対象にランジオロールの循環動態に及ぼす影響を検討した．心拍数，平均動脈圧，中心静脈圧，平均肺動脈圧，混合静脈血酸素飽和度，心拍出量をランジオロール投与開始前(T1)，開始後10分(T2)，20分(T3)，30分(T4) に測定した．心拍数はランジオロール投与開始前112±8回/分であったが投与開始後10分で98±10回/分，投与開始後20分で91±9回/分，30分で86±7回/分と有意に減少した．平均動脈圧は投与開始前74±16mmHgと比べ開始後10分で67±13mmHgと有意に低下したが，それ以上の低下は認められなかった．以上の結果はランジオロールはOPCAB中の上室性頻脈の改善に有用であることを示唆している．

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A 59-year-old male underwent mitral valve annuloplasty for mitral valve prolapse. The postoperative course was uneventful. However, three months after operation, he developed general malaise and dyspnea, and was readmitted to hospital. Echocardiography revealed mitral valve regurgitation(IV°), and chest x-ray showed an infiltrative shadow in the right lung. A diagnosis of interstitial pneumonia was confirmed based on an increase in serum KL-6 to 1,400 U/ml, and lung biopsy. Respiratory functions improved after about one month of mechanical ventilation and steroid pulse therapy, but 3 l/min of oxygen by nasal cannulae was still required. Chest x-ray revealed that the pneumonia had stabilized, although the serum KL-6 value remained high. Then, mitral valve replacement was performed. Extubation was done two days after surgery, and his respiration was stable thereafter. The serum KL-6 level decreased from 1,170 U/ml on the day of surgery to 541 U/ml 10 days after surgery.

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