official journal of Congeital Anomalies Research Association of Japan
Online ISSN : 2433-1503
Print ISSN : 0037-2285
Volume 11 , Issue 1
Showing 1-12 articles out of 12 articles from the selected issue
  • Type: Cover
    1971 Volume 11 Issue 1 Pages Cover1-
    Published: March 31, 1971
    Released: February 01, 2019
    JOURNAL FREE ACCESS
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  • Type: Appendix
    1971 Volume 11 Issue 1 Pages App1-
    Published: March 31, 1971
    Released: February 01, 2019
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  • Type: Index
    1971 Volume 11 Issue 1 Pages Toc1-
    Published: March 31, 1971
    Released: February 01, 2019
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  • D.J. McCallion, D.H. Carr
    Type: Article
    1971 Volume 11 Issue 1 Pages 1-3
    Published: March 31, 1971
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    The fetus described in this paper was obtained from a therapeutic abortion by saline induction. The CR length of the fetus is 145 mm. The following anomalies are described: cleft of the soft palate; enlargement of the liver; pronounced hydronephrosis in the left kidney; malrotation of the gut; and herniation of the colon inferior to the gluteus maximus muscle. The position of the hernia suggests congenital insufficiency of the iliococcygeus and ischiococcygeus muscles, through which, intra-abdominal pressure caused the hernia.
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  • Hiroshi SASAKI
    Type: Article
    1971 Volume 11 Issue 1 Pages 5-13
    Published: March 31, 1971
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    A single high dose of actinomycin D was given to the Sprague-Dawley rats and ICR-JCL mice intraperitoneally during the period of organogenesis. While LD_<50> Values reported in non-pregnant rats were smaller than those in mice, i. e., the toxic effects of actinomycin D in the rats were much greater than those in the mice but the lethal effects of the drug for the rat fetuses were much lower than for the mice fetuses. The fluctuation in the mortality in the mouse fetuses per mother seemed to be larger than those in the rat fetuses. The malformations in the rat fetuses were those of the central nervous system, eye, viscera, etc., while in the mouse such a pattern of malformations was not detectable. The incidence of malformed rat fetuses were much higher than in the mouse. In case of the ICR-JCL mice, a single injection using the effective dose range presented maximal teratogenic and lethal effects when the chemical was given on day 8 of gestation. In case of the Sprague-Dawley rat, lethal effects to the fetuses presented a maximum incidence when injected on day 9 and the teratogenicity was revealed to be the most apparent when it was given on day 8.
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  • S.M. Tuli, Shamer Singh
    Type: Article
    1971 Volume 11 Issue 1 Pages 15-17
    Published: March 31, 1971
    Released: February 01, 2019
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    An anadidymous chick with three beaks and three eyes is reported. Gross morphology of the anomaly and the nature of twinning is discussed.
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  • Yoshikuni TANIOKA, Kozaburo ESAKI, Chuhei YAMAUCHI, Tatsuji NOMURA
    Type: Article
    1971 Volume 11 Issue 1 Pages 19-23
    Published: March 31, 1971
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    In order to study the effect of change in environmental temperature on the incidence of malformations induced by ethyurethane injection, four groups of pregnant ICR-JCL mice were prepared : An EU+Hi-T group of mice was exposed to a temperature of 31±2℃ for 13 hours after intraperitoneal administration of 1,500mg,/kg of ethylurethane on day 10 of gestation ; Hi-T group was exposed to a temperature of 31±2℃ for the same period as above ; an EU group of mice intraperitoneally administered with 1,500 mg/kg ethylurethane ; and a control group was kept at normal temperature without administration of ethylurethane. All mice were put to death on day 18, and the mortality of embryos and fetuses, and gross malformations in living fetuses were observed. There was little difference between the mortalities of embryos and fetuses in the EU+Hi-T and EU group (17.5 per cent and 14.5 per cent), as shown Table, 1. A variety of malformations were observed, and cleft palate and finger malformations frequently seen in EU and EU+Hi-T groups, as shown in Table 2 and Fig. 1. Malformations of fingers and tails occurred more frequently in the EU+Hi-T group than in the EU group, as shown in Table 2. Cleft palate and malformations of the hind limb were observed slightly more in the EU+Hi-T group, but the difference did not show the statistical significance. The above results indicate that changes in the environmental temperature influenced on the teratogenicity of ethylurethane.
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  • Type: Appendix
    1971 Volume 11 Issue 1 Pages 25-36
    Published: March 31, 1971
    Released: February 01, 2019
    JOURNAL FREE ACCESS
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  • Type: Appendix
    1971 Volume 11 Issue 1 Pages 37-
    Published: March 31, 1971
    Released: February 01, 2019
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  • Type: Appendix
    1971 Volume 11 Issue 1 Pages 38-
    Published: March 31, 1971
    Released: February 01, 2019
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  • Type: Cover
    1971 Volume 11 Issue 1 Pages Cover2-
    Published: March 31, 1971
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    Download PDF (23K)
  • Type: Cover
    1971 Volume 11 Issue 1 Pages Cover3-
    Published: March 31, 1971
    Released: February 01, 2019
    JOURNAL FREE ACCESS
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