official journal of Congeital Anomalies Research Association of Japan
Online ISSN : 2433-1503
Print ISSN : 0037-2285
Volume 12 , Issue 3
Showing 1-15 articles out of 15 articles from the selected issue
  • Type: Cover
    1972 Volume 12 Issue 3 Pages Cover1-
    Published: September 30, 1972
    Released: February 01, 2019
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  • Type: Appendix
    1972 Volume 12 Issue 3 Pages App1-
    Published: September 30, 1972
    Released: February 01, 2019
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  • Type: Index
    1972 Volume 12 Issue 3 Pages Toc1-
    Published: September 30, 1972
    Released: February 01, 2019
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  • Yoshinobu MUTO
    Type: Article
    1972 Volume 12 Issue 3 Pages 139-146
    Published: September 30, 1972
    Released: February 01, 2019
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    1) Nucleolar size in the presumptive skeletal mesoderm of the limb bud was examined in toad larvae reared at an optimal temperature of 20±1℃ and those reared at a high temperature of 30±1℃. 2) The nucleolar size in larvae reared at the high temperature became markedly smaller than in those reared at the optimal temperature, at the onset of differentiation of the precartilage. 3) Reduction in nucleolar size was discussed in connection with reduction in mitotic rate, presumably causing defective digital malformations.
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  • Yoshiro KAMEYAMA, Yasushi HAYASHI, Kiyoshi HOSHINO
    Type: Article
    1972 Volume 12 Issue 3 Pages 147-156
    Published: September 30, 1972
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    1. The experiment was designed to examine the vascularity of the brain mantle of X-ray induced microcephaly in mice, in order to elucidate the pathogenesis of circulatory disorders which occurred postnatally and would play an important role for the manifestation of hydrocephalus. 2. CF # I female mice were exposed to a single whole-body X-radiation at a dose of 200R on day 13 or 15 of pregnancy. The brains of the offspring were examined in vascular specimens with india ink injection and histological sections stained with H. E. or gallocyanine. 3. Abnormal vascular pattern and poor vascular network of the neopallium were demonstrated to exist in the microcephalic brains with aberrant cortical structure. A distinct correlation both in degree and in site between the abnormal vascular pattern and the histological aberration of the cortical structure was found. The results suggest a causal relationship between prenatal abnormal vascular formation in the brain mantle and cerebral venous congestion with hemorrhage manifested postnatally. The authors wish to thank Dr. Kyoji Kondo, Professor of the Department of Animal Breeding, Faculty of Agriculture, Nagoya University, for his instructions in X-ray ad-ministration. The authors also acknowledge the technical assistance of Mr. Osamu Fujii, Research Institute of Environmental Medicine, Nagoya University.
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  • Ujihiro MURAKAMI, Kiyoshi HOSHINO, Minoru INOUYE
    Type: Article
    1972 Volume 12 Issue 3 Pages 157-171
    Published: September 30, 1972
    Released: February 01, 2019
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    1. Three groups of Wistar rats were subjected to a single dose intraperitoneal injection of 0.2 mg/kg, 0.225 mg/kg and 0.25 mg/kg of vincristine on day 8 of pregnancy, respectively. Follow-up studies from day 11 to 20 were conducted. 2. In those examined on day 13, there were cases with slight elevation, protrusion or unevenness on the top of the cranial surface and there were also cases with cloud or plications in the brain wall observable from the outside. After day 14 or 15, cases were detected that fall into the category of brain hernia,transitional conditions of a kind of cranioschisis with a small opening. 3. Such abnormal changes initiated from grouping and migration of neural cells had the appearance of neural elements usually situated in the deeper part of the neural tissue. These changes seem finally to lead to outgrowth or plications of the neural tissue, and such changes were tentatively called disorganization of the neural tissue or midbrain. In the above changes, rosettes were often evident. 4. Based on this observation, it is presumable that besides the common process of anencephalia formation in the sense of Giroud's concept, i. e. , caused by failure of the neural tube closure (primary in nature), there exists that of a secondary nature, resulting from reopening of the neural tube once closed. The eversion of the brain tissue, however, was not extensive. 5. Coexistence of rosettes in the initial change taking place in the above process called disorganization of the neural tissue suggested that such process might be due to proliferative nature.
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  • Toshihiro TAKEUCHI
    Type: Article
    1972 Volume 12 Issue 3 Pages 173-189
    Published: September 30, 1972
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    A few population studies on congenital malformations in Japan encouraged the auther to investigate the frequency of and the affecting factors on the occurence of congenital malformations in a birth cohort at the defined area, NAGOYA. The 41, 028 live born babies in 1965 were followed up for 4 years by linking birth and death certificates. The subjects analysed in this study are 96 deaths with congenital malformations of 644 deaths in the follow-up period and 42 malformed babies of 807 late stillbirths in 1965. Cardiovascular system accounts for a half of the malformations among the deaths and central nervous system for nearly two thirds among the stillbirths. Significantly high frequencies of malformations are observed among babies with the following characteristics ; 1) short gestational period (8 or 9 months) 2) low birth weight (less than 2,501 grams) 3) twin birth 4) high birth order (fourth or more) 5) old mother (35 years old or more) 6) long duration of parental wedlock (7 years or more) 7) working mother (sales-, service-women and farmers) 8) illegitimate birth Some of malformations interestingly showed the increasing or decreasing tendency of their frequencies with advancing parental age. These results suggest that the congenital malformations of multifactorial origin may be prevented by better family planning and some sort of modification of socio-economic factors.
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  • Hideo NISHIMURA
    Type: Article
    1972 Volume 12 Issue 3 Pages 191-193
    Published: September 30, 1972
    Released: February 01, 2019
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  • Kazushige NAKAMURA
    Type: Article
    1972 Volume 12 Issue 3 Pages 195-197
    Published: September 30, 1972
    Released: February 01, 2019
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  • Takayoshi IKEDA
    Type: Article
    1972 Volume 12 Issue 3 Pages 199-201
    Published: September 30, 1972
    Released: February 01, 2019
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  • Type: Bibliography
    1972 Volume 12 Issue 3 Pages 203-215
    Published: September 30, 1972
    Released: February 01, 2019
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  • Type: Appendix
    1972 Volume 12 Issue 3 Pages 216-218
    Published: September 30, 1972
    Released: February 01, 2019
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  • Type: Appendix
    1972 Volume 12 Issue 3 Pages 219-
    Published: September 30, 1972
    Released: February 01, 2019
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  • Type: Cover
    1972 Volume 12 Issue 3 Pages Cover2-
    Published: September 30, 1972
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    Download PDF (34K)
  • Type: Cover
    1972 Volume 12 Issue 3 Pages Cover3-
    Published: September 30, 1972
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    Download PDF (34K)
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