official journal of Congeital Anomalies Research Association of Japan
Online ISSN : 2433-1503
Print ISSN : 0037-2285
Volume 24 , Issue 2
Congenital Anomalies
Showing 1-7 articles out of 7 articles from the selected issue
Original Article
  • 1984 Volume 24 Issue 2 Pages 75-82
    Published: 1984
    Released: July 09, 2021
    JOURNAL OPEN ACCESS
    ABSTRACT The patterns in the cleft lip and palate were classified in great detail, and the point of center of the clefts in this disease was speculated. The purpose of the present study was to establish the basic data for classifications of epidemiological surveys in the future. The subjects were 377 patients with cleft lips and palates who visited the Second Department of Oro-Maxillo-Facial Surgery, Aichi- Gakuin University Hospital. The models of cleft lip and palate divided into 17 segments prepared for an analysis of cleft patterns. And as consequence, the following results were obtained. (1) The starting point cleft lip and that in palate are considered to be different. (2) The highest incidence in these cleft patterns was observed in the left vermilion type, and the lowest was in the right anteria one third of hard palate.
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  • 1984 Volume 24 Issue 2 Pages 83-87
    Published: 1984
    Released: July 09, 2021
    JOURNAL OPEN ACCESS
    ABSTRACT Pyrimethamine was mixed with mashed feed and given to pregnant sows of Goettingen miniature pig through a part of the period of organogenesis. A high incidence of the major malformations such as cleft palate, club foot and micrognathia was observed in 13 out of 24 newborns from 5 pregnants which received a teratogenic dose (3.6 mg/kg of body weight/day) from day 11 to day 22 of gestation, the first half of the organogenetic period. Only one cleft palate was observed among the 23 newborns from 4 pregnants administered the same dose through the second half of the period. Among the 51 newborns from 10 pregnants which received the same dose through the first or second quarter, only 4 newborns showed external major malformations. However, 19 out of 38 live newborns without external major malformations in these groups died within 2 days after birth. Clinical symptoms of these neonatally dead young were similar to splayleg, a naturally occurring functional anomaly in pigs. No internal malformation was revealed by the autopsy of these dead newborns.
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  • 1984 Volume 24 Issue 2 Pages 89-101
    Published: 1984
    Released: July 09, 2021
    JOURNAL OPEN ACCESS
    ABSTRACT Radiation of 2 MeV neutrons was used to induce conotruncal anomalies experimentally in chick. White leghorn eggs were exposed to a single dose of neutrons ranging from 50 to 250 rads at various stages of the development. Cardiovascular anomalies were found in 209 (40%) of 526 treated embryos; conotruncal anomalies (81/209 or 39%), simple VSD (56/209 or 27%), isolated aortic arch anomalies (69/209 or 33%) and others (3/209 or 1%). The conotruncal anomalies were induced at considerably high incidences by exposures during the 3rd day of incubation and the highest incidence was 74% in the cases malformed by 220 rads. The types of conotruncal anomalies observed were as follows: VSD with pulmonary overriding (52 cases), VSD with aortic overriding (11 cases), DORV (10 cases), truncus arteriosus (6 cases) and complete TGA (2 cases). Sixty (74%) of these cases had aortic hypoplasia, constituting coarctation or interruption complex similar to that seen in man. It is generally thought that the experimental production of complete TGA in chick appears to be impossible when utilizing ordinary teratogenic means. However, neutron radiation could induce this peculiar anomaly in chick.
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  • 1984 Volume 24 Issue 2 Pages 103-110
    Published: 1984
    Released: July 09, 2021
    JOURNAL OPEN ACCESS
    ABSTRACT Litters from the non-treated dams in Sprague-Dawley (SD) and Wistar rats which are used most frequently in reproduction studies were observed for strain differences concentrating on the behavioral development during the early postnatal stage. During the period before the eyelids open, the Wistar rats showed significantly earlier development of postural reflex and traction than the SD rats. However, during the period after eyelids open, the significant difference between these two strains disappeared. The numbers of fallings from a rotorod, ambulation, and rearing in the SD strain significantly increased as compared with those in the Wistar strain. These findings suggest that proper caution should be paid to the developmental period for observing the postural reflex and traction response for the particular strain.
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  • 1984 Volume 24 Issue 2 Pages 111-121
    Published: 1984
    Released: July 09, 2021
    JOURNAL OPEN ACCESS
    ABSTRACT Teratogenic effects of azosemide, a loop diuretic, were investigated in rats, mice and rabbits. Azosemide was given orally to pregnant rats, mice and rabbits during organogenesis. The pregnant animals were killed at term and their fetuses were examined for external, visceral and skeletal abnormalities. In rats, azosemide at 10-30 mg/kg/day did not affect intrauterine growth, resorptions and rates of external and visceral malformations. Treatment with 90 mg/kg/day resulted in a significant increase in skeletal abnormalities such as wavy ribs, bent scapula and bent humerus. However, the skeletal abnormalities observed in term fetuses could not be found in adult offspring, indicating that they were temporary. In mice, 1250 mg/kg/day of azosemide caused maternal death, abortion, and retarded maternal and fetal weight. Treatment with 200-500 mg/kg/day did not induce fetal mortalities, external and visceral malformations. Skeletal abnormalities increased in dose-dependent fashion. The type of abnormalities was identical to that encountered in rat fetuses. Furosemide as a positive control also produced similar types of skeletal abnormalities in mouse fetuses. In rabbits, azosemide did not have embryolethal or teratogenic effects even at the highest dose (6 mg/kg/ day), which caused maternal death. Treatment for a different 3-day period and then a different day during organogenesis in rats and mice showed that the sensitive period was days 15-17 of gestation with a peak on day 16 in rats, and days 12-15 with a peak on day 13 in mice.
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  • 1984 Volume 24 Issue 2 Pages 123-131
    Published: 1984
    Released: July 09, 2021
    JOURNAL OPEN ACCESS
    ABSTRACT A system of rapid and comprehensive access to the literature of developmental toxicity, including teratogenicity, of environmental agents has been developed and operated by the Environmental Teratology Information Center (ETIC). On-line retrieval services have been provided through TOXLINE and RECON. The ETIC file has accommodated about 31,500 reports on 8720 agents selected from 3000 sources as of November 1, 1983. In this communication, the history and present status of ETIC is introduced and an example is presented on how to utilize the ETIC file by TOXLINE in Japan. ETIC welcomes requests of members of our Society to use the file and also expects to receive more Japanese references since ETIC has a Japanese technologist.
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  • 1984 Volume 24 Issue 2 Pages 133-144
    Published: 1984
    Released: July 13, 2021
    JOURNAL OPEN ACCESS
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