ABSTRACT The purpose of this study is to ascertain possible cytological effects
of vitamin A administration to pregnant mice on the fat-storing cells (Ito cell) in
the fetus liver. Though many external anomalies were occurred in the fetus when
vitamin A was given once on day 8 of gestation, it is conceivable that the appearance
of these teratogenicity may not be concerned in Ito cell because liver had not
yet developed at this stage. When vitamin A was given once a day for four days
consecutively from day 14 to day 17 of gestation little external anomalies were
appeared. By electron microscopy, cytological changes were found in Ito cell,
especially the number of lipid droplets in the cytoplasm conspicuously increased.
This proved that vitamin A administered to the mothers was carried into the fetuses
through the placenta and Ito cells of the fetus liver had an ability to absorb vitamin
A at the late stage of pregnancy.
ABSTRACT Abnormalities of erythroid cells in the bone marrow of anemic CFO
mice (healhea) with hereditary congenital erythroblastic anemia were not evident,
while abundant erythroblasts, especially orthochromatophilic erythroblasts, were
observed in the circulation and many showed abnormalities. Among them by
electron microscopy, cytoplasmic aggregations of ribosomes and cytoplasmic
lattice-like inclusions were characteristic of the hereditary congenital erythroblastic
ABSTRACT One male Japanese patient diagnosed as probable Hypertelorism-
Microtia-Clefting (HMC) syndrome was presented. In addition to the striking clinical
findings including a cleft palate, and eye and ear anomalies, chromosomal
analysis revealed a karyotype of 46,XY,t( lq-;7pt).
The radiographic examinations based on cephalometric analysis have been added
to an appreciation of the craniofacial dysmorphology of this patient. The comparative
study between the present case and 38 cleft palate patients without other
anomalies clearly disclosed characteristic craniofacial dysmorphology of this case,
including platybasia, bony orbital hypertelorism, short anterior face, and micrognathia.
Particularly, this micrognathia was distinguished by marked antegonial
notch, short ramus height, and clockwise rotation resulting in the steep mandible.