ABSTRACT The clinical features of 18 patients diagnosed as having preaxial polydactyly and hallux varus were studied. There are three types of hallux varus: 1) the medial great toe is pushed out by the lateral overldpping great toe, 2) the great toe is inverted by the deformed first metatarsus, and 3) the great toe is inverted by anchoring substance of the hypo- plastic or degenerative medial great toe. The general diagnosis of “hallux varus” may be reasonable based on the com- mon appearance, but the clinical features of these three types differ from each other. The patients with hallux varus caused by anchoring of the hypoplastic or degenerative medial great toe should be strictly differentiated from the patients with hallux varus due to deformity of the metatarsus. Special consideration for treatment is needed for each type.
ABSTRACT ICR mice were treated intraperitoneally with mitomycin C (MMC) at a single dose of l-5mg/kg on day 0, 1, 2 or 3 of pregnancy (vaginal plug = day 0). Embryotoxicity and teratogenicity were examined at term. A dose-dependent increase in fetal mortality and decrease in the number of im- plants, fetal weight or number of ossified sacral and caudal vertebrae were observed. The incidence of external malformation, umbilical hernia, significantly increased among the fetuses of dams treated with MMC at Smg/kg on day 1, 2 or 3. Skeletal malformation failed to show significant increase though some fetuses from MMC- treated mice were attended with multiple defects such as fusion of ribs or axial skeleton. Maternal contribution to and the direct action of MMC on embryonic develop- ment were investigated by embryo transfer. In regard to malformation inducement and decrease in implants, the maternal environment was found to have more signifi- cant effect than the direct action of this drug but both these factors are significant- ly responsible for increased fetal mortality and growth retardation.
ABSTRACT A symposium on the ethical problems in teratology was held to con- sider the problems that may occur in the research and therapy of the medical sciences. Selected titles of the symposium were as follows: 1. Some cytogenetical aspects of artificial fertilization. 2. Abortion: Ethical issues and Japanese attitudes. 3. Ethical problems of congenital malformations; “fetal therapy in utero” 4. Ethics in autopsy of human fetuses and newborns with congenital anomalies. 5. Genetic counseling. 6. Logic and ethics of learning (Gakumon).
These broad problems were discussed in all their aspects.