official journal of Congeital Anomalies Research Association of Japan
Online ISSN : 2433-1503
Print ISSN : 0037-2285
Volume 27 , Issue 1
Congenital Anomalies
Showing 1-5 articles out of 5 articles from the selected issue
  • 1987 Volume 27 Issue 1 Pages 1-10
    Published: 1987
    Released: July 21, 2021
    JOURNAL OPEN ACCESS
    ABSTRACT An autopsy case of the unilateral cryptophthalmia syndrome was presented, showing the lack of the eyelids formation on the right and the facial skin being continuous over the right eye. Potter's face, partial cutaneous syndactyly, clitorial hypertrophy, bilateral renal agenesis and absence of uterus were associated, and further laryngeal atresia was noted, leaving a small posterior opening and allowing a survival of only 10 min at birth. Histologic analysis of the right eye revealed that the cyst in the anterior segment was formed by the destruction of the lens itself. The pathogenesis of cryptophthalmia and laryngeal atresia was discussed.
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  • 1987 Volume 27 Issue 1 Pages 11-16
    Published: 1987
    Released: July 21, 2021
    JOURNAL OPEN ACCESS
    ABSTRACT A case of persistent stapedial artery is presented. The patient was a 49-year-old man who had suffered from tinnitus in the left ear and bilateral hearing impairment for 20 years. The preoperative audiological ex- aminations showed considerable combined hearing loss, suggesting middle ear anomalies or otosclerosis. An exploratory tympanotomy on the left ear was per- formed, and complete fixation of the stapedial footplate and a small vessel running vertically on the footplate were observed. By reconstructive surgery using a pros- thesis, postoperative hearing improved. The histological examination of the re- moved portion of the stapes showed an otosclerotic lesion. Cases of persistent stapedial artery found in the literature were discussed from the clinical and em- bryological viewpoint.
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  • 1987 Volume 27 Issue 1 Pages 17-22
    Published: 1987
    Released: July 21, 2021
    JOURNAL OPEN ACCESS
    ABSTRACT The interaction between methylmercury teratogenesis and manifesta- tion of cleft lip and palate (CUP)) of genetic origin was experimentally investigated in CL/Fr mice. Pregnant mice were given methylmercuric chloride orally on day 10 of pregnancy at doses of 5, 10, 15 and 20 mg/kg. Animals were put to death on day 18 of pregnancy and the fetuses were examined for malformations, especial- ly facial anomalies. About 23% of fetuses manifested CL(P) in the control group. After maternal treatment with methylmercuric chloride, the incidence of fetuses with CL(P) did not remarkably change in groups of 5 mg/kg (about 3%) and 10 mg/kg (about 24%), but decreased significantly (p < 0.01) in groups of 15 mg/kg (about 12%) and 20 mg/kg (about 12%). The average numbers of both early and late fetal deaths in the mercury-treated groups were not significantly different from those in the control group (p < 0.05): This suggested that the decreased incidence of fetuses with CUP) was not attributable to the preferential mortality of embryos with CUP). The incidence of isolated cleft palate (CP) was about 1, 5,40 and 80% after maternal treatments of 5,10,15 and 20 mg/kg methylmercuric chloride, respec- tively, showing the distinct threshold. No significant difference in mercury con- centration was observed among normal fetuses, fetuses with CUP) and with CP within any dose group.
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  • 1987 Volume 27 Issue 1 Pages 23-29
    Published: 1987
    Released: July 21, 2021
    JOURNAL OPEN ACCESS
    ABSTRACT In the purpose to learn the teratogenic effects of tritium, tritiated water of 50, 75, 100, 125 and 15OmCi was injected into the abdominal cavity of pregnant rats individually on days 7, 8, 9, 10 and 11 of pregnancy, respectively, and the anomalies that developed were studied on day 18 of pregnancy. The anomalies occurred at the highest frequency in the cases administered with lOOmCi on day 9 of pregnancy, the anomalies combined accounting for 81.3 7% of the implanted embryos (100 % of the surviving embryos). Among them, cardio- vascular anomalies accounted for 68.8 % of the implanted embryos (84.6 7% of the surviving embryos). The LDsO was 132mCi in cases administered on day 9 of pregnancy.
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  • 1987 Volume 27 Issue 1 Pages 42-43
    Published: 1987
    Released: July 21, 2021
    JOURNAL OPEN ACCESS
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