日本先天異常学会会報
Online ISSN : 2433-1503
Print ISSN : 0037-2285
7 巻, 2 号
選択された号の論文の14件中1~14を表示しています
  • 原稿種別: 表紙
    1967 年 7 巻 2 号 p. Cover1-
    発行日: 1967/06/30
    公開日: 2019/02/01
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  • 原稿種別: 付録等
    1967 年 7 巻 2 号 p. App1-
    発行日: 1967/06/30
    公開日: 2019/02/01
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  • 原稿種別: 目次
    1967 年 7 巻 2 号 p. Toc1-
    発行日: 1967/06/30
    公開日: 2019/02/01
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  • デイパオロ J.A.
    原稿種別: 本文
    1967 年 7 巻 2 号 p. 61-63
    発行日: 1967/06/30
    公開日: 2019/02/01
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    Many parallelisms exist between teratogenesis and carcinogenesis. Somatic cell division is a prerequisite for both. Of the small number of compounds which have been bioassayed for both effects, the majority have produced malformations and cancer. The same compound may have different effects, dependent upon the stage of development of the organism at the time of exposure. Thus, a compound found to be carcinogenic to mature cells might be teratogenic to immature, embryonic cells. Some chemical agents given during fetal life produce cancer which becomes obvious during postnatal life. Oncology appears to have evolved further than teratology in that a number of clearly stated hypotheses have been proposed concerning the concepts of somatic mutation, alteration of immune response, protein deletion, and altered regulatory circuits. A review of pertinent literature in both disciplines indicates that these hypotheses of carcinogenesis may be applicable to studies in teratogenesis. Evidence on the mechanism of a carcinogenic agent might be used to elucidate its possible teratogenic activity. Conversely, detailed studies in organogenesis which are required for teratology can serve as a framework for carcinogenic investigation.
  • エバート J.D.
    原稿種別: 本文
    1967 年 7 巻 2 号 p. 64-65
    発行日: 1967/06/30
    公開日: 2019/02/01
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  • 安田 峯生, 有行 史男, 西村 秀雄
    原稿種別: 本文
    1967 年 7 巻 2 号 p. 66-73
    発行日: 1967/06/30
    公開日: 2019/02/01
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    ICR-JCL系マウスの妊娠全期間を通じ硫酸ampehamine 50mg/kgを経口投与し,さらに妊娠10日にtriethylene thiophosphoramide(thio-TEPA)3mg/kgを腹腔内に投与してaこの催奇形効果がamphetamineにより影響を受けるか否かを検索した.比較のためamphetamineのみ,またはthio-TEPAのみを受けた動物と,無処置対照群とを用意した.母動物については毎日体重,水・餌摂取量を測定したが,amphetamineの減食作用は投与開始後2日間認められたのみであった.妊娠18日に母体を殺して胎仔を観察した結果,amphetamine単独適用群で軽度の胎仔死亡率の上昇,thio-TEPA単独群およびamphetamine+thio-TEPA群で生仔平均体重の減少が認められたが,各群の一腹仔数には差なく,また,その催奇形閾値に近いと思われるthio-TEPA 3mg/kg量の催奇形効果はamphetamineにより影響されなかった.
  • 堀井 欣一
    原稿種別: 本文
    1967 年 7 巻 2 号 p. 74-80
    発行日: 1967/06/30
    公開日: 2019/02/01
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    Unpedigreed white virgin mice were mated with mature male mice from the same colony. Five groups of copulated female mice were treated with a single intravenous injection of 80 mg per kg body weight alloxan on the 4th, 5th, 6th, 7th and 8th days of gestation respectively (the 4th-, 5th-, 6th-, 7th- and 8th-day groups). All mice were weighed on the 1st and 19th days of gestation, and blood sugar levels were tested 48 hours following the alloxan injection and on the 19th day of pregnancy. Pregnant mice were sacrificed on the 19th day of gestation, and fetuses were removed immediately by laparotomy and examined for externally visible defects. The fetal skeleton was examined for deformities after being stained with a dilute aqueous alizarin red-S solution. The frequency of mothers with one or more malformed fetuses was about 30 percent of successful pregnancies, and that of malformed fetuses was about 5 percent of live-borns in each group. The occurrence of fetuses having defects of the central nervous system decreased progressively with later treatments of alloxan during the period from the 4th to 8th days of gestation, and it was presumed that the defects might no longer appear with the alloxan injection after the 10th day of gestation. Hereupon, any noticeable relationship was not particularly seen between the frequency of over-all deformities and the date of alloxan treatment. No appreciable difference in blood sugar levels was observed between mice with and without malformed fetuses. On the other hand, however, fetal defects were found more frequently in mothers with a subnormal increase of the body weight as compared with mothers showing a sufficient increase during the period of pregnancy.
  • 城戸 国利, 神谷 啓造, 鈴木 瞭, 林 進
    原稿種別: 本文
    1967 年 7 巻 2 号 p. 81-86
    発行日: 1967/06/30
    公開日: 2019/02/01
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    A case of newborn malformation with microcephalus, crania bifida through which a mass of substantia cerebrovasculosa protruded, huge bilateral polycystic kidneys and uterus separata duplex et septum vaginae was reported. The mother of the newborn, whose mate was her cousin, is 1 gravida, and 1 para with an anencephalus. In the 2nd stage of labor, the head of the infant was delivered smoothly, but the trunk could not pass through the birth canal due to the huge polycystic kidneys, and the infant died with the enlarged abdomen and legs remaining in the uterine cavity. In order to diminish the body size of the infant, the polycystic kidneys were removed through the birth canal. The necropsy-findings of the newborn are as follows : Age ; 38 weeks of gestation (premature female). Bodyweight ; 2480g. Stature ; 43cm. The head is very small, the abdomen is enormously enlarged, and the brain is 80g, a quarter of the normal one. A part of the occipital bone has a defect of 1.5cm in diameter, and a soft red purple mass of 3cm in length is protruding from there, the base of which is connected to the brain itself. The kidneys, the right one weighing 220g, the left 440g, have the appearances of multiple cysts and seem to have caused the enormous enlargement of the abdomen described above. The microscopic examination revealed that the kidneys were composed of elongated cysts lined with a single layer of low cuboidal cells, mass of immature cells, which were probably of mesenchymal origin, and increased connective tissues, The weight of other organs are as follows : the heart 24g, the right lung 8.6g, the left 6.0g the liver 130g, the spleen 13.5g, the pancreas 3.0g, the thyroid gland 1.0g, the thymus 3.1g, and the right adrenal gland 1.5g, (the left had been lost during the removal of the huge kidneys). In the sex organs is found the complete duplication of the uterus, cervix, and vagina. The right and the left organs are located symmetrically, and almost of the same size.
  • 西村 秀雄
    原稿種別: 本文
    1967 年 7 巻 2 号 p. 87-89
    発行日: 1967/06/30
    公開日: 2019/02/01
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  • 原稿種別: 文献目録等
    1967 年 7 巻 2 号 p. 91-109
    発行日: 1967/06/30
    公開日: 2019/02/01
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  • 原稿種別: 付録等
    1967 年 7 巻 2 号 p. 110-
    発行日: 1967/06/30
    公開日: 2019/02/01
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  • 原稿種別: 付録等
    1967 年 7 巻 2 号 p. 111-
    発行日: 1967/06/30
    公開日: 2019/02/01
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  • 原稿種別: 表紙
    1967 年 7 巻 2 号 p. Cover2-
    発行日: 1967/06/30
    公開日: 2019/02/01
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  • 原稿種別: 表紙
    1967 年 7 巻 2 号 p. Cover3-
    発行日: 1967/06/30
    公開日: 2019/02/01
    ジャーナル フリー
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