official journal of Congeital Anomalies Research Association of Japan
Online ISSN : 2433-1503
Print ISSN : 0037-2285
Volume 8 , Issue 1
Showing 1-14 articles out of 14 articles from the selected issue
  • Type: Cover
    1968 Volume 8 Issue 1 Pages Cover1-
    Published: March 31, 1968
    Released: February 01, 2019
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  • Type: Appendix
    1968 Volume 8 Issue 1 Pages App1-
    Published: March 31, 1968
    Released: February 01, 2019
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  • Type: Cover
    1968 Volume 8 Issue 1 Pages Cover2-
    Published: March 31, 1968
    Released: February 01, 2019
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  • Tsuneyoshi Sakurai
    Type: Article
    1968 Volume 8 Issue 1 Pages 1-11
    Published: March 31, 1968
    Released: February 01, 2019
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    1) Mice of the ddN and CF#1-JCL strain were subjected to a single whole body X-irradiations of 200R and 300R from day 7 to 12. In the ddN strain, abundant eye malformations were produced in those treated on day 8 and 11 while in the CF#1 strain the peak of the eye malformations produced was only on day 7. 2) Both the above strains of mice were subjected to the X-irradiation of 200R on day 11 and embryos were taken out 6, 12, 18, and 24 hours after the treatment. Thereafter, fetuses were also taken out at one day intervals. They were examined both grossly, by free hand razor blade sections, and partially under a microscope. 3) Microscopically, cellular necroses were evident in the primordial retina, especially in the internal layer of it. Debris eliminated by phagocytes continued 24 hours after X-irradiation in the ddN strain. However, such debris were continuously seen until 48 hours when the repair was completed. However, in the CF#1 strain, the involved eye presented an almost normal appearance 24 hours after the treatment. In the CF#1 strain, the eye in treated embryos was normally developed while in the ddN strain, the size of the eye was apparently small or the development was retarded suggesting sequencial microphthalmos. 4) Such divergences in the development from day 11 to 12 seemed to be caused by the difference in progress in the development in the primordial eye in the ddN strain. Further, the process in repair was also evidently retarded in the ddN strain. Conclusively, the above divergences may be caused by differences in developmental potencies between these two strains of mice employed.
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  • Kozaburo Esaki, Yoshikuni Tanioka, Tatsuji Nomura
    Type: Article
    1968 Volume 8 Issue 1 Pages 13-17
    Published: March 31, 1968
    Released: February 01, 2019
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    In order to examine the effect of the change in the environmental temperature on the incidence of malformations induced by hypervitaminosis-A, four groups of pregnant ICR-JCL mice were prepared; the VA + HT group of mice was exposed to a temperature of 34 ± 1℃ for 16 hours after administration of 5,000 I. U. of vitamin A on day 10; the HT group of mice was exposed to a temperature of 34 ± 1℃ for 16 hours at the same time as the above; the VA group of mice was administered with 5,000 I. U. of vitamin A, but kept at normal temperature ; the control group of mice was kept at normal temperature without administration of vitamin A. A11 mice were sacrificed on day 18, and the mortality of embryos and fetuses, and gross malformations in the living fetuses were observed thereafter. The mortality of embryos and fetuses in the VA + HT group (22.4%) was higher than that of the other groups (10-11%) .The occurence of malformations of the living fetuses in the VA + HT, the VA, the HT and control groups were 66.2%, 48.1%, 2.4% and 0.9%, respectively. Cleft palate was observed in 40.3% and 27.2% of the living fetuses in the VA + HT and the VA groups, respectively. The above results indicate that the change in the environmental temperature affects the teratogenicity of an overdose of vitamin A. Other workers also reported that teratogenicity is influenced by various environmental factors such as the season, food, noise, etc. Therefore, environmental controls are very important in animal experiments in teratology .
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  • Toshio Yamaguchi
    Type: Article
    1968 Volume 8 Issue 1 Pages 19-30
    Published: March 31, 1968
    Released: February 01, 2019
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    This study was done in order to examine the effects of vitamin B_<12> on the manifestation of malformations in the Wistar rat fetus due to maternal hypervitaminosis-A during pregnancy . The hypervitaminosis-A in the pregnant rats was produced by oral administrations of vitamin A at a dose of 30,000 I.U./100g body weight from the 10th to the 13th day of pregnancy. The vitamin B_<12> was administered subcutaneously at a dose of 1.0γ/100g (small dose) or 10γ/100g (large dose) at the same gestational days of vitamin A administrations. The results were as follows: 1. The simultaneous administrations of vitamin B_<12> either at the small or large dose, revealed an action to reduce the adverse effect of hypervitaminosis-A on the fetal growth. 2. The incidence of gross malformations in the offsprings was 38.6 % in the group treated with both vitamin-A and the small dose of vitamin B_<12> while thc incidence was 82.6%; in that treated with vitamin A alone. Among the malformations manifested in this experiment, facial malformations such as microtia, open eyelid, macroglossia, macrognathia, cleft palate and lower jaw cleft were predominant. In the group treated with vitamin A and the large dose of vitamin B_<12> on the contrary, the incidence of gross malformations was not so different from that in the group treated with vitamin A alone. 3. The growth of thc fetal skeletons was examined in the states of ossification of the occipital bone, sternebrae, metacarpi, metatarsi and coccyges. Neither the small nor large dose of vitamin B_<12> affected markedly the retardation of ossification due to hypervitaminosis-A. 4. The small dose of vitamin B_<12> brought about an apparent preventive effect on thc manifestations of the 14th rib, brachygnathia and the malformations of the long bones of extremities due to hypervitaminosis-A. On the contrary, the administration of the large dose showed a tendency to increase the number of the fetuses with brachygnathia, malformed humerus or the 14th rib due to hypervitaminosis-A.
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  • Fumihiko Ohta, Toshio Monju, Haruo Saito
    Type: Article
    1968 Volume 8 Issue 1 Pages 31-38
    Published: March 31, 1968
    Released: February 01, 2019
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    A case of congenital fistula of the lower lip was clinically and pathologically examined. The patient was a nine months old female baby. The fistula was opend below the left portion of the lower lip at a distance of about 5 mm from the vermilion border and the depth of the fistula was about 10 mm. The opening of the fistula was encircled by a red-colored crest, feature which was similar to the lip. The fistula manifested itself unilaterally and its opening situated apart from the vermilion border of the lower lip. There was no association with cleft lip or palate, and also no evidence of hereditary relationship. The fistula was extirpated surgically and was examined microscopically. The histological findings were similar to those of congenital fistulas of the lower lip which manifested themselves bilaterally on the lower lip in general. The first case of congenital fistula of the lower lip was reported by Demarquay in 1845. Since then more than 380 cases have been reported,, The typical cases were those manifested on the lower lip bilaterally and symmetrically. Most cases reported previously had genetic bases and many of them were accompanied with cleft lip or/and palate. While, the unilateral manifestation have been rarely reported and only two cases of unilateral fistula situated apart from the red portion of the lip have been reported (Berauds and Birkett). If the fistulas were originated from a pathological development of the lower lip, unilateral manifestation would be more found as frequent as unilateral cleft lip. Therefore, the hypothesis that the fistula is resulted from the physiological sulci on the lower lip in the early embryonic stage (Stieda, Sicher, Pohl, etc.) seem to be reasonable. The authors presumed that the fistula of this case may have etiological somethings in common with the congenital bilateral, cleft of the lower lip which was reported by Abramsen.
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  • Heinz BERENDES
    Type: Article
    1968 Volume 8 Issue 1 Pages 39-45
    Published: March 31, 1968
    Released: February 01, 2019
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    The Collaborative project for the Study of Cerebral Palsy, Mental Retardation and Other Neurological and Sensory Disorders of Infancy and Childhood represents the joint endeavor of 14 medical centers in the United States and the National Institute of Neurological Diseases and Blindness. Planning started in 1957, with data collection beginning in January 1959. Admission of obstetrical patients into this program ended on December 31, 1965, at which time some 60,000 pregnancies had been registered. Children born in 1959 are just beginning to return for their comprehensive 7-year examinations. The objective of this Study is to determine relationships between factors affecting women during pregnancy and the neurological and sensory disorders of their offspring. In an attempt to identify whether lowering of the fetal heart is associated with neurological or mental deficits in surviving children, the following approach was used drawing on information collected as part of the Perinatal Collaborative Project. Children were identified born during the first three years of this program, and therefore at least 4 years old, who were derived from pregnancies in which at least one observation of a fetal heart rate below 80 was recorded. No differences in mean IQ or IQ under 70 were seen in children who had low fetal heart rates in the first or second stage of labor as compared to the population from which they were drawn. There were small differences observed in certain neurological findings, particularly in children with low fetal heart rates during the first stage of labor. More of these children appeared to be abnormal neurologically than expected. Comparison of the frequency of indicators of fetal distress, that is low fetal heart rate, meconium staining, low 1- or 5-minute Apgar score, suggests a difference between children with various types of cerebral palsy compared to controls. An increase was found in children with cerebral palsy. Small differences in prenatal indicators of distress were observed among children with complex diplegia. Low Apgar scores were noted specifically among children with spastic diplegia.
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  • [in Japanese]
    Type: Article
    1968 Volume 8 Issue 1 Pages 47-49
    Published: March 31, 1968
    Released: February 01, 2019
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  • Type: Appendix
    1968 Volume 8 Issue 1 Pages 51-57
    Published: March 31, 1968
    Released: February 01, 2019
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  • Type: Appendix
    1968 Volume 8 Issue 1 Pages 58-61
    Published: March 31, 1968
    Released: February 01, 2019
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  • Type: Appendix
    1968 Volume 8 Issue 1 Pages 62-
    Published: March 31, 1968
    Released: February 01, 2019
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  • Type: Cover
    1968 Volume 8 Issue 1 Pages Cover3-
    Published: March 31, 1968
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    Download PDF (50K)
  • Type: Cover
    1968 Volume 8 Issue 1 Pages Cover4-
    Published: March 31, 1968
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    Download PDF (50K)
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