official journal of Congeital Anomalies Research Association of Japan
Online ISSN : 2433-1503
Print ISSN : 0037-2285
Volume 9 , Issue 2
Showing 1-15 articles out of 15 articles from the selected issue
  • Type: Cover
    1969 Volume 9 Issue 2 Pages Cover1-
    Published: June 30, 1969
    Released: February 01, 2019
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  • Type: Appendix
    1969 Volume 9 Issue 2 Pages App1-
    Published: June 30, 1969
    Released: February 01, 2019
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  • Type: Index
    1969 Volume 9 Issue 2 Pages Toc1-
    Published: June 30, 1969
    Released: February 01, 2019
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  • Naomasa OKAMOTO
    Type: Article
    1969 Volume 9 Issue 2 Pages 45-59
    Published: June 30, 1969
    Released: February 01, 2019
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    The literature related to cardiovascular anomalies experimentally produced by various agents were discussed accordiug to the following items. 1. Heredity Incidences and types of congenital cardiovascular anomalies were described in various species, breeds and strains, or families of animals. The experimental data of reciprocal mating in rats and fowls to rule out the intrauterine environmental factors were explained. II. Physical or mechanical factors l Irradiation a External irradiation (X-ray or neutron) 1) Local irradiation i) Irradiation of different parts of the heart rudiment ii ) Irradiation of wide transverse strips behind the heart 2 ) Direct irradiation to the embryo without exposure of the mother to radiation 3) Whole-body irradiation of the pregnant mother b Internal irradiation (^<32>P) 2 Hemodynamic factors Cardiovascular anomalies induced by direct surgical manipulation of the developing heart of the embryo and other organs were discussed. 3 Hypoxia and excess-CO_2 Cardiac malformations induced by anoxia and exposure of the mother to carbon dioxide during pregnancy were described. 4 Others a) Stimulation of the central nervous system b) Temperature variations Elevation of temperature was not teratogenic with respect to the heart. Cardiovascular anomalies were produced in the decreasing temperature. III. Viral infections Since Gregg's report, there have been many reports on the frequency of abnormalities in children whose mothers had been suffering from rubella during early pregnancy. Few experimental work** have been done. VI. Hypo- or Hypernutrition 1 Vitamin A a) Deficiency b) Hypervitaminosis 2 Riboflavin (lactoflavin) deficiency 3 Pteroylglutamic acid (PGA), folic acid deficiency 4 Vitamin E deficiency 5 Panthothenic acid deficiency (to be concluded)
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  • Yoshinobu MUTOH
    Type: Article
    1969 Volume 9 Issue 2 Pages 61-73
    Published: June 30, 1969
    Released: February 01, 2019
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    l) The skeletons of the hindlimbs in 61 toad larvae with various digital malformations induced by cultivation at a high temperature of 30±10℃ were observed. 2) The most frequent skeletal anomalies were reduction in number or size, further various types of fusion in "small tarsalia" i.e. , the centrale and tarsalia 1 and 2+3, and hypophalangism which was always recognized in toes I, III, IV and V, the prehallux, and sometimes in toe II. 3) Other frequent anomalies were those in the metatarsus: reduction, fusion and flexion of metatarsalia. 4) No significant anomalies were recognized in the femur. The tibio-fibula and "large tarsalra" ,i. e., the astragalus and the calcaneum were usually normal or nearly normal with a few exceptions. 5) The deficiency of the skeletal element in the prehallux was frequently supplied by the centrale fused with the "prehallucal metatarsale" or rarely by the involvement of the rudimentary metatarsale I into the prehallux. Thus the prehallux was not eliminated even when toe I was reduced.
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  • Isamu KIMURA
    Type: Article
    1969 Volume 9 Issue 2 Pages 75-86
    Published: June 30, 1969
    Released: February 01, 2019
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    Morphogenetic and developmental studies were attempted on congenital microphthalmia in the mc-inbred-strain of mice. Most microphthalmia in the mc-strain close the eye lid, and some of them open slightly. In anatomical observation of adult mc-mice, average size of microphthalmic eye was less than 1/3 as compared to the normal strains, DDK and C57BL/6J. However, there exist considerable variation in the eye ball: from very small or anophthalmia to almost normal eye size, but all of them had abnormal ophthalmological structures. Embryological studies have shown that deformity of the eye began in the eye cup around day 11 and the diturbance in the eye cup seems to obstruct the subsequent ophthalmological character. The development and growth of the microphthalmic eye were supposed to be influenced by environmental factors in embryonic and postnatal stage. The hypothesis of a single autosomal mc-gene could not be confirmed in this study, but it could be said there exist a special gene or genes in mc-strain. The mc-gene or genes shows some pleiotropic effect to the nasal bone and tooth.
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  • Kazushige NAKAMURA, Tamotsu MATSUO
    Type: Article
    1969 Volume 9 Issue 2 Pages 87-92
    Published: June 30, 1969
    Released: February 01, 2019
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    After intraperitoneal injections of neutral red, trypan blue, carmin or bilirubin solutions into rat fetuses on the 17th or 18th day after gestation, the fetuses were killed 48 hours after injection. Serial sections of the fetal brain were made to study how the pigments transport into the brain. As a result, no pigments were observed in the fetal brain in normal states. In the hypoxic state, by clamping the uterine vessels, however, the transportation of pigments into the brain was slightly observed in the solution of 1.0-0.1% of neutral red or O.2% of bilirubin. This may result from the functional decrease of the blood-brain barrier by hypoxia. Based on these facts, it may be presumed that this phenomenon may have the possibilty of being correlated with the mechanism of kernicterus.
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  • Ujihiro MURAKAMI
    Type: Article
    1969 Volume 9 Issue 2 Pages 93-99
    Published: June 30, 1969
    Released: February 01, 2019
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  • Type: Appendix
    1969 Volume 9 Issue 2 Pages 101-109
    Published: June 30, 1969
    Released: February 01, 2019
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  • Type: Appendix
    1969 Volume 9 Issue 2 Pages 110-112
    Published: June 30, 1969
    Released: February 01, 2019
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  • Type: Appendix
    1969 Volume 9 Issue 2 Pages 113-114
    Published: June 30, 1969
    Released: February 01, 2019
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  • Type: Bibliography
    1969 Volume 9 Issue 2 Pages 115-
    Published: June 30, 1969
    Released: February 01, 2019
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  • Type: Appendix
    1969 Volume 9 Issue 2 Pages App2-
    Published: June 30, 1969
    Released: February 01, 2019
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  • Type: Cover
    1969 Volume 9 Issue 2 Pages Cover2-
    Published: June 30, 1969
    Released: February 01, 2019
    JOURNAL FREE ACCESS
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  • Type: Cover
    1969 Volume 9 Issue 2 Pages Cover3-
    Published: June 30, 1969
    Released: February 01, 2019
    JOURNAL FREE ACCESS
    Download PDF (26K)
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