CHEMOTHERAPY
Online ISSN : 1884-5894
Print ISSN : 0009-3165
ISSN-L : 0009-3165
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Volume 19, Issue 4
Displaying 1-6 of 6 articles from this issue
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  • [title in Japanese]
    1971 Volume 19 Issue 4 Pages 237-287
    Published: July 25, 1971
    Released on J-STAGE: March 08, 2011
    DOIhttps://doi.org/10.11250/chemotherapy1953.19.237
    JOURNAL FREE ACCESS
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  • SENSITIVITY TEST OF ANTICANCER DRUG FOR TUMOR CELL IN VIVO II
    Sensitivity Test of Anticancer Drug for Solid Tumor in Diffusion Chamber
    SEIJI SOEJIMA, KIMIO SATO, YOSHINOBU ISHIKAWA
    1971 Volume 19 Issue 4 Pages 288-293
    Published: July 25, 1971
    Released on J-STAGE: March 08, 2011
    DOIhttps://doi.org/10.11250/chemotherapy1953.19.288
    JOURNAL FREE ACCESS
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    In the author's experiment with diffusion chamber technique the morphological histochemical changes as well as the change in DNA synthesis of experimental solid tumor of rat proved to be available as indicating the sensitivity of the tumor to anticancer drug in diffusion chamber inserted in homologous and heterologous host.
    This technique contributed also to the evaluation of mitomycin on solid type of Hirosaki sarcoma, Yoshida sarcoma and AH 66. Hirosaki sarcoma, Yoshida sarcoma were highly sensitive and AH 66 was low sensitive to mitomycin.
    This experiment is a basic study to gain access to the investigation on sensitivity test of anticancer drug for human tumor cell in vivo.
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  • STUDIES ON AMINODEOXYKANAMYCIN IN URINARY TRACT INFRCTION
    YOSHIAKI KUMAMOTO, SHOGO SHIMAMURA, KATSUYUKI MITOBE, KINICHI IKAWA
    1971 Volume 19 Issue 4 Pages 294-298
    Published: July 25, 1971
    Released on J-STAGE: March 08, 2011
    DOIhttps://doi.org/10.11250/chemotherapy1953.19.294
    JOURNAL FREE ACCESS
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    Laboratory and clinical studies were done on aminodeoxykanamycin (AKM) in urinary tract infection. Results are as follows.
    1) Sensitivity test by disc method revealed that AKM had almost same antibacterial activity to KM. But minimum inhibitory concentration of AKM to E. coli and Proteus species were one or two dilution lower than that of KM.
    2) Clinical application of AKM (daily 200-400mg i.m.) to female acute cystitis showed satisfactoy effectiveness without remarkable side effect.
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  • ON THE OTOTOXICITY OF TUBERACTINOMYCIN-N
    MASATOYO AKIYOSHI, KIICHI SATO, MUNETOSHI YOSHIZAWA, KAZUO HAYANO
    1971 Volume 19 Issue 4 Pages 299-302
    Published: July 25, 1971
    Released on J-STAGE: March 08, 2011
    DOIhttps://doi.org/10.11250/chemotherapy1953.19.299
    JOURNAL FREE ACCESS
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    The present study was made to evaluate the ototoxicity of tuberactinomycin-N (TUM-N), a new peptide antibiotic isolated from the culture broth of the mutant strain of Streptomyces griseoverticillatus var. tuberacticus, on the guinea pig. Fify-two guinea pigs of the Hartley strain (300 g) were used. TUM-N, TUM, viomycin (VM), kanamycin (KM) and capreomycin (CPM) were injected at the dose of 400 mg/kg/day intramuscularly for 28 days, respectively.
    Basing on the results of the Pinna reflex test and histopathological examination of the damage of the most sensitive outer hair cells of the organ of Corti in the guinea pigs, it was concluded that TUM-N is the most mild in ototoxicity among VM, KM and CPM in the present study
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  • POST-OPERATIVE LOCAL INJECTION THERAPY OF ROLITETRACYCLINE IN ORTHOPAEDIC FIELD
    KAZUO OHMIYA
    1971 Volume 19 Issue 4 Pages 303-310
    Published: July 25, 1971
    Released on J-STAGE: March 08, 2011
    DOIhttps://doi.org/10.11250/chemotherapy1953.19.303
    JOURNAL FREE ACCESS
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    Rolitetracycline (PRM-TC) was used by this author in local wounds after many kinds of orthopaedic surgeries. It was applied by injection into the wounds soon after operations while the patients were still under anesthesia, and every case had already received the injection of the new drugs before surgery. There were 87 cases whose ages ranged from 3 to 83.
    There were sufficiently good results with minimum doses of the new antibiotics in pre- and post-operative administrations; for example, the average doses of the new drugs were 650 mg (1. 4 ampoules) by injection and the other antibiotics were administered per os only 4.8 days in addition.
    No serious side-effects were found among all of the 87 cases, and no symptoms of post-operative infection were observed except one patient who was suffering from osteomyelitis. In particular, 15 cases had no other antibiotics except local injection of PRM-TC.
    At the aseptic operation, and the like the antibiotics were injected intravenously 90 minutes before surgery, when the blood concentration reached its peak, and just at that time operations could be performed. In addition, as soon as the operation was finished PRM-TC was injected locally into the wound, and the use of the new antibiotics was not needed thereafter. PRM-TC is a highly commendable drug, if used for the above purpose with the method above mentioned.
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  • CLINICAL TRIAL WITH A NEW ANTICANCER AGENT, SOEDOMYCIN
    TETSUO KITAHARA, SHIZUO HOMMA, NORIHISA SATO, MOMOE SOEDA, HIROSHI SUM ...
    1971 Volume 19 Issue 4 Pages 311-319
    Published: July 25, 1971
    Released on J-STAGE: March 08, 2011
    DOIhttps://doi.org/10.11250/chemotherapy1953.19.311
    JOURNAL FREE ACCESS
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