In order to compare the curative effect and side effect of cephradine (CED) with those of amoxicillin (AMPC), comparative clinical experiments have been carried out by means of a double blind method upon 195 patients of pneumonia in 28 institutions throughout the country. CED was administered orally for 2 weeks at a daily dose of 2 g, and AMPC was administered similarly at a daily dose of 1 g. Both subjective and objective symptoms were observed in detail and various examinations were also performed. The clinical effectiveness was judged by a doctor in charge as well as by committee members composed of several doctors. This committee interpreted the chest X-ray films of all cases following a certain standard, and judgement of severity and effectiveness was made on every case individually before opening the key code. On the contrary, the numerical judgements of severity and clinical effectiveness were made on the base of individual symptoms and examination data. When the key code was opened, comparison was made on the homogeneity of background factors of the patients as well as aeverity in both groups of drug administration, and the clinical effectiveness and side effect were determined statistically.
Among 195 cases of drug administration (92 cases of CED and 103 cases of AMPC), 12 cases were excluded because of the following reasons-5 cases : different schedule of administration, 5 cases : pulmonary tuberculosis, one case : lung cancer and pleurisy, one case : atelectasis after bronchography. No significance was observed between the two treatment groups regarding the background except age groups of male. Clinical effectiveness judged by doctors in charge was excellent 20 : 23 (CED : AMPC, respectively), good 43 : 53, fair 11 : 5, poor 7 : 9, aggravated 1 : 3, evaluation impossible 5 : 3, thus showing no significance between the two groups. Side effects were seen in 16 cases of CED (5 cases : symptoms, 12 cases : laboratory abnormalities) and 20 cases of AMPC (7 cases : symptoms, 13 cases : laboratory abnormalities). Drug administration was discontinued in 4 cases of AMPC due to the side effect, but in none of CED. No significance was seen between the two groups either on the side effect or on the utility.
The committee members excluded 33 cases of CED and 27 cases of AMPC to strictly compare the drug effectiveness on pneumonia. In the adopted 59 cases of CED and 76 cases of AMPC, no singificance was observed on the backgrounds except age groups of male. Clinical effectiveness judged by committee members was excellent 4 : 5, good 38 : 50, fair 4 : 12, poor 13 : 9, and showed no significance. No significance was observed on the clinical effectiveness by numerical judgement either.
Regarding the degree of improvement in CRP, the group of AMPC was better than that of CED, and the latter was better than the former regarding the degree of improvement in volume of sputum. No significance was observed in the two groups as for improvement of symptoms
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