CHEMOTHERAPY
Online ISSN : 1884-5894
Print ISSN : 0009-3165
ISSN-L : 0009-3165
25 巻, 6 号
選択された号の論文の10件中1~10を表示しています
  • 大越 正秋, 河村 信夫, 上田 泰, 松本 文夫, 熊本 悦明, 丸田 浩, 本間 昭雄, 土田 正義, 森田 隆, 大堀 勉, 吉田 郁 ...
    1977 年 25 巻 6 号 p. 1587-1603
    発行日: 1977/08/25
    公開日: 2011/03/08
    ジャーナル フリー
    To study the efficacy and the safety of Cefapirin, we performed a double-blind test in treatment of pyelonephritis, using Cephaloridine as control drug for comparison. In this experiment, we obtained the following results :
    1) Total number of patients was 112 cases (consisting of Cefapirin-group 56 cases, and Cephaloridine-group 56 cases). For the background factors, there were no significant differences between Cefapirin-group of 42 cases and Cephaloridine-group of 44 cases, except 26 cases which were omitted out from the statistical treatment.
    2) For all the cases, except omitted 26 cases, or totally 86 cases (42 cases of Cafapirin-group and 44 cases of Cephaloridine-group), the clinical results were as mentioned below according to the judge of the responsible doctor :
    The excellent result and the good result were obtained, respectively, in 16 cases (38%) and in 17 cases (40%) of Cefapirin-group, while in 16 cases (36%) and in 11 cases (25%) of Cephaloridine-group. As far as the rate of excellent efficacy, as well as that of good efficacy, is concerned, no significant difference was found between both groups. According to the evaluation by the Committee, there was no significant difference between Cefapirin-group and Cephaloridine-group for the results obtained on the day 3 as well as for the results obtained on the day 10. However, in patients with non-complicated pyelonephritis (22 cases in Cefapirin-group and 21 cases in Cephaloridine-group), the evaluation on the day 3 by the Committee showed that the results obtained in Cefapirin-group was significantly superior to that obtained in Cephaloridine-group (P<0.05).
    3) For the improvement rate of pyuria in patients with non-complicated pyelonephritis, the findings obtained in Cefapirin-group were significantly better than those obtained in Cephaloridine-group (P< 0.05).
    4) The side effects were found in 3 cases of Cefapirin-group and in 8 cases of Cephaloridine-group. The occurrence of side effects was slightly higher in Cephaloridine-group. However, in Cefapirin-group, the cessation of treatment was necessary in 2 patients (because of nausea in one case and of itching in the other).
    5) The increase in BUN, caused by drug administration, was found in one patient treated with Cephaloridine, the augmentation of values of S-GOT and S-GPT was observed also in Cephaloridine-group (in 2 cases), while neither increase in BUN nor increase in S-GOT or S-GPT in Cefapirin group.
  • 中野 博
    1977 年 25 巻 6 号 p. 1604-1608
    発行日: 1977/08/25
    公開日: 2011/03/08
    ジャーナル フリー
    The influence of water diuresis on the absorption and excretion of mecillinam after the oral administration of pivmecillinam at the dose of 146. 2 mg (equimolar to 100 mg mecillinam) was studied in six healthy male adults on three different experimental states by the cross over method ; the state 1, hydropenic one by overnight fasting, the state 2, hydropenic one shifted to hydrated one by the intravenous infusion of 1, 000 ml of 5% glucose solution in 60 minutes, 3 hours after the administration of the drug, and the state 3, hydrated one by the same method as the state 2 followed immediately after dosing.
    The concentrations of mecillinam in the serum or urine and the amounts excreted in the urine after the administration of pivmecillinam were compared between the three states, and the following results were obtained.
    1) The differences between each serum concentration of the three states were statistically not significant.
    2) The averages of the urinary concentration within 3 hours after dosing were 319. 5, 173. 5 and 38. 5 jug/ml in the state 1, 2 and 3 respectively, and the differences between the state 3 and 1 (P<0. 01), and 2 (P<0. 05), were statistically significant. But in the state 3, the average of the urinary level during the period of 3-6 hours after dosing was 103. 5 μg/ml and it was significantly higher than that during the period of 3-6 hours after dosing.
    3) The differences of the cumulative amount of mecillinam excreted in the urine within 3 hours after dosing were statistically not significant between the three states, but the amount in the state 3 during the period of 3-6 hours after dosing was statistically higher than those in the other two states (P< 0. 01). The averages of the urinary recovery rate within 6 hours after dosing were 28. 1, 27. 5 and 43. 1 % in the state 1, 2 and 3 respectively, and the differences between the state 3 and 1, and the state 3 and 2, were statistically significant (P<0. 01).
  • 大野 虎之進, 高畠 弘
    1977 年 25 巻 6 号 p. 1609-1616
    発行日: 1977/08/25
    公開日: 2011/03/08
    ジャーナル フリー
    The isolation frequencies and the resistance to antibiotics of various bacterial species from patients in the Department of Obstetrics and Gynecology of Tokyo Dental College, Ichikawa Hospital were studied in 1968, 1970, 1972 and 1974.
    Antibiotics used for the sensitivity studies included ; ampicillin (ABPC), cephalexin (CEX), cephalo-ridine (CER), nalidixic acid (NA), streptomycin (SM) and kanamycin (KM).
    The results obtained were as follows :
    1. The isolation frequency of gram-negative bacilli had increased from 30. 96% in 1968 to 69. 49% in 1974. Among many of the gram-negative bacilli, E. coli showed the most remakable increase.
    2. The isolation frequency of gram-positive cocci was 69. 49% in 1968 and decreased to 30. 50% in 1974.
    3. Sensitive strains of gram-negative bacilli (E. coli, Klebsiella, and Proteus) to ABPC, CEX and CER have been decreasing yearly, but those to NA, SM and KM were almost unchanged.
    4. The increased incidence of the resistance of Staphylococcus aureus to ABPC was noted, but incidence of the resistance of Staphylococcus aureus to CEX, SM and KM had not significantly increased.
    5. Streptococcus faecalis has shown good sensitivity to ABPC, but the incidence of its resistance to CEX, CER, NA, SM and KM has rapidly increased.
  • 諸条件下の宿主における制癌剤感受性の差異について
    副島 清治, 稲葉 馨, 西田 伝, 永野 叡
    1977 年 25 巻 6 号 p. 1617-1623
    発行日: 1977/08/25
    公開日: 2011/03/08
    ジャーナル フリー
    The sensitivities of anticancer drugs for tumor cell in the hosts with the various conditions were compared.
    1) Growth of tumor cell was strongly effected by cellular factor than by humoral factor in host.
    2) The grade of sensitivity of anticancer drug for tumor cell showed difference by the conditions of host.
    3) Sensitivity of anticancer drug for tumor cell was exactly showed by only humoral factor in host.
    4) So, in order to obtain sensitivity of anticancer drug for tumor cell, the test must be investigated in vivo. And tumor cell must not be strongly influenced by host. Therefore the diffusion chamber technique is useful as sensitivity test of anticancer drug for tumor cell.
  • TADAHIRO WATANABE, TAKAHIRO ISHII, KEINOSUKE MIYAUCHI, Yuzo KAZUNO, SH ...
    1977 年 25 巻 6 号 p. 1624-1629
    発行日: 1977/08/25
    公開日: 2011/08/17
    ジャーナル フリー
    The structure-activity relationship was studied on 9-acyl derivatives of midecamycin, and 9-acyl and 9-acetyl-4 “-acyl derivatives of 4” -depropionylmidecamycin. Acyl substitution at position 9 of the lactone ring of midecamycin resulted in general in a decrease of in vitro activity, but some of derivatives were superior in in vivo activity. 9-Acyl substitution of 4 “-depropionylmidecamycin retained in vitro bioactivity equal to that of the starting material, and showed improved in vivo activity.
    4” -Acyl substitution of 9-acetyl-4″-depropionylmidecamycin resulted in an equal or slight decrease of in vitro activity, but an increase of in vivo activity. High survival rates of acyl derivatives were correlated with high blood concentration.
  • 教育講演他
    1977 年 25 巻 6 号 p. 1630-1650
    発行日: 1977/08/25
    公開日: 2011/03/08
    ジャーナル フリー
  • 新薬シンポジウム
    1977 年 25 巻 6 号 p. 1650-1666
    発行日: 1977/08/25
    公開日: 2011/03/08
    ジャーナル フリー
  • 一般演題
    1977 年 25 巻 6 号 p. 1666-1739
    発行日: 1977/08/25
    公開日: 2011/03/08
    ジャーナル フリー
  • 招請講演他
    1977 年 25 巻 6 号 p. 1740-1753
    発行日: 1977/08/25
    公開日: 2011/03/08
    ジャーナル フリー
  • 一般演題
    1977 年 25 巻 6 号 p. 1753-1778
    発行日: 1977/08/25
    公開日: 2011/03/08
    ジャーナル フリー
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