CHEMOTHERAPY
Online ISSN : 1884-5894
Print ISSN : 0009-3165
ISSN-L : 0009-3165
3 巻, 6 号
選択された号の論文の11件中1~11を表示しています
  • 老木 英男
    1955 年 3 巻 6 号 p. 231-234
    発行日: 1955/12/25
    公開日: 2010/09/24
    ジャーナル フリー
    1) The growth of Candida albicans is inhibited, besides by B. coli, in the presence of other intestinal flora such as Staphylococcus aureus, Streptococcus, Pneumococcus, Proteus vulgaris and Pn eumobacillus. 2) The metabolic end products of Staphylococcus aureus show almost no harmful effects on the growth of Candida albicans.
    3) When the growth of fresh strain of Candida albicans is compared in the peptone medium with that of the stale, the growth rate of the fresh is about 10 times of that of stale in 48?hour culture. Generally speaking, the symbiosis of B. coli and other intestinal flora with Candida albicans seems to be sustained within the limit of a certain balance of existence, which may be broken on the administration of antibiotics by the diminution or elimination of some of the sensitive organisms. In such a case, the energy source, mostly glucose; normally consumed by B. coli and other intestina flora will remain unused and be utilized by Candiiic albicans causing its excessive growth.
  • 大久保 滉, 星崎 東明
    1955 年 3 巻 6 号 p. 235-237
    発行日: 1955/12/25
    公開日: 2010/09/24
    ジャーナル フリー
    1)In synthetic medium adde d with riboflavin, pyridoxin, folic acid or biotin, the development ofresistance was more promoted than in vitaminmedium.
    2) Whereas the growth of resistant mutants was delayed than that of parent strains in vitamin-free medium, resistat mutants were equally or more promoted the growth than parent stains, when one of vitamins was added.
    3) Those vitami ns seem to have some growth promoting factor to streptomycin resistants of E. coli.
  • 李 建星
    1955 年 3 巻 6 号 p. 238-246
    発行日: 1955/12/25
    公開日: 2010/09/24
    ジャーナル フリー
    スルフアミン剤(S剤)の治療界に於ける地位は抗生物質が実用化された現在でも脚かも揺ぎない。このS剤の効果増強,毒性低滅,アレルギー反応その他の副作用軽減を目的として混合S剤がA.R.FRISK1(1946年)により着想された。この新らしい化学療法剤の試みは現在まで多数の研究者により検討されて効果が確認され,広く臨床上の普及をみているが,実地応用に必要な指標となるS剤の血中濃度及び尿中排泄の問題については未だ充分明かにされたとは言えない。著者は混合S剤の内服時に於ける血中及び尿中S剤の消長を直接把握するためにThiobarbituricacid(TBA)を試薬に用いるSulfadiazine(SD)の特異的定量法,即ちTBA-testを利用して混合S剤の吸収及び排泄を検討して臨床上興味ある知見を得たので,ここにその結果を報告する。
  • 岡崎 正義
    1955 年 3 巻 6 号 p. 247-259
    発行日: 1955/12/25
    公開日: 2010/09/24
    ジャーナル フリー
    Since it is plausible that the nucleotic-acid metabolism may be affected by bile, especially bileacid salt consisting of main component in it be assumed to play its principal role, it appears suggestive that the gene in bacterial cell may be inflicted with a variation. As the mechani sms in regard to the acquirement of durg-resistance, on the other, are, according to recent investigation, to be closely indivisible to the nueleotic-acid metabolism through their way to resistant aquirement, so some form of variant genes are inevitablely induced. In order to make these quesetionable points clear, the infuences of bile and its fraction to the resistant Staphylococcus aureus and Pneumococcus produced by antiobiotics are experimentally studied in vitro, and following results were obtained. 1) The resistance of Staphylococcus aureus and Pneumococcus to penicillin are inhibited to so me extent by bile. 2) In fractions of bile, bile-salt, especially desoxy?cholic acid Na, and taurocholic acid, are most influential on the resistance of bacilli. 3) There has been no influence On the resistant Staphylococcus aureus and Escherichia colt to streptomycin. 4) Also no influence is to be found in resistance of tubercle bacilli to streptomycin a nd INAH and back-mutation of them. 5) Bile makes the highly resistant Staphylococcus aureus sensitive to antibiotics to some extent, while not to other bacilli. 6) The Staphylococcus aureus and Pneumococcus pre-treated with bile differs from their original strains in behaviors to resistance, the for mer be reversible, while the latter inreversible.
  • 相沢 春海
    1955 年 3 巻 6 号 p. 260-266
    発行日: 1955/12/25
    公開日: 2010/09/24
    ジャーナル フリー
    In order to study the influ ences of various antibiotics and antifungal drugs upon the metabolism of C. aibicans, I have investigated their influences upon the adaptive enzymes of the cells. Using a living cell suspension of C. alb. (F. D. A. No. 1001) as an enzymic preparation which cultured on Sabouraud-glucose agar media at 37. 5 °C for about 24 hours, I have studied the influen ces of various drugs (final concentration 1-10 mcgfcc) upon adaptive oxidation of substrates by using manometric technique of WARBURG. 1. Mannose and galactose are adaptively oxidized by C. alb.
    2., Both the respiration and the adaptive oxidation of mannose and galactose are inhibited by 8-hydroxyquinoline. merzonin. 2-methy1-3-merca pto1: 4 -naphthoquinone, aureot hricin, candimycin, eurocidin and trichomycin, but not affected by penicillin G, chlortetracycline, oxytetracycline, chloramphenicol, dihydrostreptom ycin, propylparaben, so called “Dehyroacetic acid” and natrium azide.
    3. In the case of using mannose or galactose adapted cells, the oxidation of mannose or galact ose is inhibited by 8-hydroxquinoline, m erzonin, 2-methyl-3-mercapto-1: 4-naphthoquinon e, aureothricin and candimycin, but not affected b y eurocidin and trichomycin. Namely eurocidin a nd trichomycin inhibit the formation of the ad aptive enzymes.
  • 1955 年 3 巻 6 号 p. 267-276
    発行日: 1955/12/25
    公開日: 2010/09/24
    ジャーナル フリー
  • 1955 年 3 巻 6 号 p. 277-283
    発行日: 1955/12/25
    公開日: 2010/09/24
    ジャーナル フリー
  • 1955 年 3 巻 6 号 p. 284-290
    発行日: 1955/12/25
    公開日: 2010/09/24
    ジャーナル フリー
  • 1955 年 3 巻 6 号 p. 291-295
    発行日: 1955/12/25
    公開日: 2010/09/24
    ジャーナル フリー
  • 1955 年 3 巻 6 号 p. 296-300
    発行日: 1955/12/25
    公開日: 2010/09/24
    ジャーナル フリー
  • 1955 年 3 巻 6 号 p. 301-307
    発行日: 1955/12/25
    公開日: 2010/09/24
    ジャーナル フリー
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