The drug susceptiblity pattern and frequency of detection of β-lactamases-producing strains were investigated in probable causative organisms among clinical isolates obtained in our laboratory in 1995 mainly cases of from community-acquired pneumonia and aspiration pneumonia. The results are summarized as follows;
1. The detection frequency of β-lactamase-producing strains were high against methicillinresistant
Staphylococcus aureus (MRSA) of
S. aureus subsp.
aureus, penicillin-resistant
Streptococcus pneumoniae (PRSP) of
S. pneumoniae,
Haemophilus influenzae, and
Moraxella subgenus
Branhamella catarrhlis, and multiple drug resistant strains of
Pseudomonas aeruginosa were a large. When the drug susceptiblity pattern was antibacterial spectrum of Empiric therapy against mainly community-acquired pneumonia, sulbactam/ampicillin (SBT/ABPC) appeared to be high effective. Because, the MIC
90 of SBT/ABPC was low against S. pneumoniae including PRSP, β-lactamase-producing
H. influenzae and
M.(B.) catarrhalis.
2. The drug susceptiblity pattern of microaerophilus gram-positive cocci (
Streptococcus milleri group,
Gemella morbillorum),
Peptostreptococcus spp.,
Bacteroides spp. and
Prevotella spp. suggested that the detection frequency of cephem (CEP)-, erythromycin (EM)-and clindamycin (CLDM)-resistant strains was high against in the
S. milleri group,
Peptostreptococcus spp. and
Bacteroides spp., and that the detection on ferquency of CEP-and EM-resistant strains were high among
G. morbillorum and
Prevotella spp. The detection frequency of II -lactamase-producing strains was 80.0 % among
Bacteroides spp. and
Prevotella spp., and the MIC
90 of SBT/ABPC and sulbactam/cefoperazone was lowest among
Bacterioides spp. and
Prevotella spp. When the MIC
90 of the test drugs against those bacterial species made the drug susceptiblity pattern, the distribution of SBT/ABPC was low.
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