Japanese Journal of Chemotherapy
Online ISSN : 1884-5886
Print ISSN : 1340-7007
ISSN-L : 1340-7007
Volume 45, Issue 9
Displaying 1-7 of 7 articles from this issue
  • Hideki Fujii, Masashi Kobayashi, Yoshiro Matsumoto
    1997 Volume 45 Issue 9 Pages 741-745
    Published: September 25, 1997
    Released on J-STAGE: August 04, 2011
    JOURNAL FREE ACCESS
    To evaluate the organ penetration of flomoxef (FMOX), we investigated its concentration in serum and pancreatic juice of 14 patients after intravenous injection of a 2 g FMOX. The results obtained were as follows:
    1. The peak concentration of FMOX in serum was 134.3±32.1 μg/ml and occured 30 minutes after administration.
    2. The peak concentration of FMOX in pancreatic juice was 4.69±4.12 μg/ml and occured 30 minutes after administration.
    3. High concentrations of FMOX in pancreatic juice were observed even at 2 hours after administration.
    4. Bacteria isorated from drained pancreatic juice were mainly Escherichia coli and Klebsiella pneumoniae for which the MIC of FMOX was less than 0.1 μg/ml. Thus FMOX was affective against these bacteria in pancreatic juice.
    5. Rates of penetration of FMOX into pancreata affected by fibrosis were lower than into pan-creata without fibrosis.
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  • Toshio Saito, Yoshiro Morikawa
    1997 Volume 45 Issue 9 Pages 746-749
    Published: September 25, 1997
    Released on J-STAGE: August 04, 2011
    JOURNAL FREE ACCESS
    Sixty-two cases in which Streptococcus pneumoniae were isolated in our hospital were divided, into two groups: a group of patients with S. pneumoniae infection and a group of healthy carriers. No clear differences in the distribution and the cumulative percentage of the MIC against penicillin G, oxacillin, ampicillin, erythromycin, minocycline, vancomycin were found between the two groups. There was no significant relation between the antibiotic sensitivity of S. pneumoniae and the clinical symptoms. Respiratory tract infections caused by S. pneumoniae could be treated effectively by regularly used antibiotic.
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  • Yukimichi Kawada, Takashi Deguchi, Masahiro Nakano, Mitsuru Yasuda
    1997 Volume 45 Issue 9 Pages 750-756
    Published: September 25, 1997
    Released on J-STAGE: August 04, 2011
    JOURNAL FREE ACCESS
    The clinical significance of DNA gyrase gyrA mutations in quinolone-resitant strains of Pseudomonas aeruginosaisolated from patients with complicated urinary tract infection (UTI) was studied by investigating annual changes in ofloxacin (OFLX) resistance, incidence of DNA gyrase gyrA mutations, and the relation between gyrA mutation and bacteriological response to the fluoroquinolone treatment. OFLX-resistant (MIC≥25μg/ml) strains increased from 11.8% in 1978 to 58.6% in 1993. DNA gyrasegyrAmutation was observed in 27 (57.4%) of 47 strains isolated before fluoroquinolone treatment and in 100% of 30 strains isolated after treatment. Mutation was observed in 1 (4.8%) of the 21 strains for which the MIC of OFLX was 12.5 μg/ml or lower and in 100% of the 32 strains for which the MIC of OFLX was 25μg/ml, ughni or higher. The eradication rate for the 20 strains without mutations was 90.0%, versus 11.1% for the 27 strains with mutations. This difference was statistically significant (p<0.01). The bacteriological and clinical breakpoint of OFLX MIC was considered to be 12.5 μg/ml, and this was also the concentration at which gyrA mutations began to appear. DNA gyrase gyrAmutation was considered to be clinically important as a mechanism of the fluoroquinolone resistance of urinary isolates of P. aeruginosa.
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  • 1997 Volume 45 Issue 9 Pages 757-761
    Published: September 25, 1997
    Released on J-STAGE: August 04, 2011
    JOURNAL FREE ACCESS
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  • 1997 Volume 45 Issue 9 Pages 764-778
    Published: September 25, 1997
    Released on J-STAGE: August 04, 2011
    JOURNAL FREE ACCESS
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  • 1997 Volume 45 Issue 9 Pages 779-806
    Published: September 25, 1997
    Released on J-STAGE: August 04, 2011
    JOURNAL FREE ACCESS
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  • 1997 Volume 45 Issue 9 Pages 810
    Published: 1997
    Released on J-STAGE: August 04, 2011
    JOURNAL FREE ACCESS
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