The aims of the present investigation were to prove the presence of so-called gravidity sclerosis of the uterine arteries, to find any difference in features between portions of the uterus, and to determine the period during pregnancy at which the first sign of the sclerotic change appears in the uterine artries of swine. Materials for histolongical studies were collected from 70 sows in Sapporo, Japan.
The results obtained are summarized as follows.
1. Sclerotic changes observed in the uterine arteries were (a) hyperplastic swelling of the tunica intima with hyperplastic smooth muscle fibers, collagenous fibers and minute elastic fibers, (b) breaking and splitting of the lamina elastica interna, (c) accumulation of interstitial ground substance of polysaccharide nature in the tunica intima and tunica media, and (d) looseness of smooth-muscle tissue in the tunica media with an increase of colleganous, elastic and reticulum fibers in the tunica media and tunica adventitia, even though these changes were not so conspicuous as those in the tunica intima.
2. According to the degree of sclerotic changes, the arteries were classified into 4 types, I to IV.
On the other hand, the arteries of the uterus distributing in 8 anatomically different portions were classified into 3 groups, A, B and C, according to the pattern of appearance of the types of sclerosis.
3. The sclerotic changes were seen most remarkably in the arteries of group A which distribute in a portion of the uterus which is most closely and directly related to pregnancy. From these facts it was concluded that the sclerotic changes of the uterine arteries were induced by pregnancy.
Sclerosis was most prominent in the main stem of arteria uterina media, and slightest in the arteries of group C which distribute in the vagina and ovary. The changes of the arteries of groups A and C did not correlate to each other, but ocurred independently. The changes of the arterier of group C seem to be due to the influence of esterus. The arteries of group B which distribute in the corpus and cervix uteri and adjacent part of the uterus horn showed changes similar to those of the arteries of group A in some part and to those of the arteries of group C in other. In other words, an intermediate sort of changes was seen in the arteries of group B.
4. Sows, in which the arteries of group A show sclerosis of type III or IV, should be treated as those with a history of gestation.
5. It seems that the influence of pregnancy appears slightly at the early period of gestation, and that its heavy influence is suddenly displayed shortly after parturition, causing great chenges in the arteries.
6. In some sows were noticed several lamellar structures in the tunica intima of the uter ine arteries. According to MAXIMOW, pregnancy sclerosis of the coiled uterine arteries is irreversible, and so it is expected that such lamellar structure of the tunca intima might be produced by sevcral repeated gestations. From this point of view, the authors suggest the conception of “sclerotic gestation rings” in the uterine arteries as the sign of post pregnancy. This conception may be developed to the extent that each ring of the lamella may represent each gestation.
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