When we poured the blood of human being into a little glass tube, in which the two electrodes (cathode and anode) are installed, and transmitted the direct current to the electrodes, we noticed the fact that the coagulated blood lumped gradually on the positive pole. We called this new phenomenon "the electric coagulation-phenomenon of the blood", and made fundamental and clinical experiments on the nature of this phenomenon.I. The fundamental experiments as follows : 1) The electric coagulation-time of the blood (the time of E. C. B.) of healthy people is 50 to 51 seconds.2) It is shortened by high temperature or high voltage, 3) This phenomenon cannot be surveyed in the acidified blood.4) The phenomenon is not seen in the non-corpuscles blood, or in the blood adding the salts in large quantities.5) The phenomenon takes long time in the fibrinless blood, or in the blood adding potassium chloride or glukose in a small quantity.6) The time of this phenomenon shortens in the blood adding calcium chloride, ferric chloride, cholesterin or pepton in a small quantity.II. The clinical experiments as follows : 1) The time of E. C. B. is different in each disease : a) It is shortened in benignant anaemia, tuberculous affections, cardiac diseases etc.b) It is prolonged in malignant anaemia, miliary tuberculosis, septic endocarditis, liver diseases etc.2) When we many times observe the time of E.C.B. with the cource of the diseases, we notice, that, with the getting better of the course it takes the normal value, on the contrary, with the becoming worse it shortened or prolonged.

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It is well known that nicotine, a main poisonous substance of tobacco, often injures heart and vascular system. But nicotine alone does not affect them and at the same time bodily condition must be concidered. According to Prof. Maekawa's theory, the organ specifity of allergic change should be dominated by the substance which has affinity to the organ.Using the cardiotrope action of nicotine, allergic myocarditis was precipitated in rabbits' hearts.With the intravenous injectioin of the mixture of nicotine (0.2mg/kg) and oxen sera (2cc/kg) rabbits were sencitized for 4 days and 3 weeks hereafter re-injection was performed for 3 days. Signs of allergic myocardial lesion were found electrocardiographically and histologically, and other organs showed no histological changes. This shows the mechanism of the heart lesion due to nicotine and on the other hand verifies Prof. Maekawa's theory.

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I researched the genesis of the experimental miliary aneurysm of the rabbit's lungs that I had discovered accidentally, on various standpoints. In consequence, I considered these aneurysms as a result of the collapse of the proper parts according to their own faster and heavier hyperactivity, by means of accelerating method of arteriosclerosis, at the places where there were bifurcating parts, especially where obtuse angles formed, and on the convex surface of the blood vessel's curving.Besides these things, I considered the organic predisposition.

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According to the idea of Lehmann-Facius's cancer reaction. I succeeded in previously demonstrating of the antibody for myocardial phosphatide in the myocardial lesions' sera. And this serological reaction was named Cor-Phosphatide-Reaction (CPR).For the examinatin about the quantity of myocardial phosphatide in sera, I attempted at the folowing experiment. I sensitized vigorously the rabbits with a mixture of human myocardial phosphati de and fresh sera, and performed the precipitin reaction between this rabbits' sera (with the antibody for myocardial phosphatid) and the each dilution of patients' sera. Then, the quantities of myocardial phofphatide in sera were measured serologicaly. This reaction was named Anti-Cor-Phosphatide-Reaction (ACPR).

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When the hand was kept anout 48 cm. higher than a heart height, in various patients as well as in healthy people, the capillaries conracted and shortened. The number of visible capillaries decreased.The blood circulation in the capillaries became more rapid. The color of base decreased.When the hand was in position about 28cm.below the heart height, in all healthy people, the capillaries, especially in venous legs, . dilated and elongated. The blood circulation in the capillaries became slower. The number of visible capillaries inceased. Increase in the base color tone was noted.In majority of angioneurosis, the time required to reach maximum change was prolonged. comparing with healthy people. In anemia, it was difficult to observe the change of base color tone. In decompensative valvular disease of the heart, the grade of the change was stronger than healthy people.Some cases of pulmonary tuberculosis showed a change in capillaries similar to angioneurosis.

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Soaking an injured heart in Ringer's solution of a circular dish. I made an experiment about the distribution of action-currents by means of unipolar leads.We may bring it into a consideratin that the electrification of the heart is approximately bipolar as Craib's opinion.But against Wilson's bipolar theory, my experiment gave a proof that there could not be found a concord between a plane of dipoles and an injured surface.When an apex was injured, the position of a bipolar plane was shifted inward from an injured surface and when a side of a ventricle was done, the direction of a normal of the bipolar plane was inclined to an apex from that of an injured surface.These results can be explained by "Theory of Chaine-doublets" (Maekawa).

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The author originated a new method of potential ECG from Prof. Maekawa's orthogonal isosceles triangle coodinates. The electrodes of the right hand (φ_R) and the left foot (φ_F) was connected to one point with two wires which had same value resistance, and this point was used as the indifferent pol. From this coordinates φ_R=1/2LeadII, φ_F=-1/2LeadII ∴φ_C=0 (φ_C is the potential of this point). As the value of the resistance 30∼100 kiloohm were chosen theoretically and experimentally in case of Shimizu's apparatus (a voltage-electrocardiograph), and 10 kiloohm in case of a string-gal-vanometer. This method may be available to diagnosis of myocard through each limb lead point ECG, and to the other analysis of standard ECG by means of this coordinates, and we can catch unipolar lead from the chest or esophagus more theoretically.

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We observed statisticaly 4510 patients except malnutrition, who addmitted to the third medical clinic of Kyoto University from 1937 to 1941 (before war) and from 1942 to 1946 (after war), and moreover were massured their blood pressure at the addmitted day, and reached to the following conclusion.We believe that, the blood pressure not only the maximal pressure but minimal pressure, decline in relation to the undernourishment.

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We studied cases of chronic cor pulmonale which constitute 6.6 per cent. of autopsied patients who died of heart disease in our clinic and recognized that increased pulmonary pressure by chronic pulmonary diseases presumably burdens the right ve ntricle and leads ultimately to death from heart failure and it is shown by one case which a mediastinal tumor compressed the branches of the pulmonary artery.

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