The author performed an accurate architechtonic study about the metastasis formation of chorionepithelioma into the lung making a special reference to the manner of the artery in such cases and came to the following conclusions. (1) Most of the arteries in the lung are found to have many fibrinoid clots on the inner surface of the wall. (2) Tumor cells derived from the original focus of chorionepithelioma will be attached at first on these clots. (3) Then the tumor cells commence to develop into the clots destructing the wall of the blood vessel then and then. (4) After the destruction of the wall of the blood vessel, there may be formed a true tumor metastasis in the pulmonary tissue. (5) The formation of the fibrinoid clots is found most abundantly in the small blood vessel and very seldom in the greater one (6) These fibrinoid clots are found mostly in the miliar aneurysm which is situated in the bifurcating part or at the convex side of the blood vessel. (7) The formation of the fibrinoid clots in the arterioles of the lung is considered to be based on the allergic phenomena on one side and on the miliar aneurysm or the vein-like dilation of the arterioles on the other side which lets the formation of metastasis appear most frequently in the lung in contrast to the other organs.

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Sawada, one of the staff, has performed the experiments on the Lutembacher's syndrom in dog. In his study he has reported that the maximal limit of mitral insufficiency for survival is 1/6 excision of all chordae tendinae of mitral valve, but this limit is enlarged to 2/6 under the condition of patent foramen ovale. In view of the above mentioned experiments, the authors have observed those histological changes in myocardium that might be produced with the results obtained as follows : 1. Under the condition of patent foramen ovale, myocardial changes caused by mitral insufficiency, which particulary found in papillar muscles, are less than that are without foramen ovale. 2. In view of these facts, the authors suggest that if the patients with mitral valvular disease are given artificial interatrial septal defect, their symptoms may be improved.

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On the preceding report, I showed by the Myom-phosphatide Precipitation Reaction (M. P. R.) that the myom-phos-phatide had the affinity to myocardium. Therefore, at this experiment, 4 male and 4 female rabbits were sensitized with the oxen sera or the mixture of oxen sera and myom-phosphatide after 3 weeks, the animals were reinjected with the mixture of oxen sera and myom-phosphatide. Clinically, body-weight, temperature, urine, blood-pressure, electrocardiogram or hemogram were observed. Thereafter, the animals were killed, and their organs were investigated histologically. Although, clinically, body-weight, temperature, blood-pressure, urine snowed little remarkable change, the hemogram showed the hypothrombocytemia the electrocardiogram showed the myocardial damage in some animals after the reinjection. Histologically, the heart of female rabbits showed the allergic myocarditis specifically that were consisted of granuloma, periarteritis, perivascular or interstitial cell-infiltration, but the heart of male animals showed little pathlogical change.

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Upon the Change in pulse rate 1) Acceleration directed from head to tail: It is considered that the increase in pulse rate during centrifugalization is principally due to the fall in carotid sinus pressure as was written by Jongbloed and Armstrong. The increase in pulse rate is generally greater in hot season than cold. For in hot season the sympathetic nerve of guinea pig is relatively hypotonic and then the blood stagnation in the area of abdomen and peripheral blood vessels becomes greater in this experiment. 2) Acceleration directed from tail to head: The increase in pulse rate in the former half stage of centrifugalization ("Increased type") may have some concern with the result of Bainbridge's Reflex. The fact that this increased rate gradually decrease in the latter half stage of it may be understood by the reason why the decrease in pulse rate owing to the rise in carotid sinus pressure following the centrifugal blood stagnation in the skull may survey the increase in the formenr half stage. The cases on which Bainbridge's Reflex has no effect may belong to "Decreased type" group. 3) Acceleration directed to left or right transversely : The increase in pulse rate during centrifugalization can be explained by the decrease of the venous to the heart caused by the blood stagnation in the area of the lateral side of body. The decrease of the venous return is undoubtedly smaller than that in each same g exposure from head to tail, so the increase in pulse rate is generally smaller than that in the exposure from head to tail. 4) The appearance of arrhythmia: Judging from the results in the supplemental experiment II & III, it is regarded that the chief causative factor for it's appearance is perhaps the change in the extracardiac nerve tone caused by the sudden change in the venous return. Upon the change in each wave 1) The change in the height of P_II : It is considered that in the centrifugalizations directed from head to tail and to 1. or r. transversely, the enlargement of P is chiefly due to the decrease in blood filling in the auricle, and in the exposure from tail to head the reduction of P is in the reverse order due to the increase in blood filling. 2) The change in the height of R_II : The condition of the rotation of the electric axis (c. f. Report VIII) and the change in blood filling in the ventricle during centrifugalization may be regarded as the chief important factors for the change in the height of R. According to the various combinations of both factors, the changes (enlargement, reduction or remaining invariable) of R may be contributed. But judging from the general type of the change in centrifugalization to each direction, the latter factor seems to be more effective than the former. 3) The change in the height of positive T_II : The general change of positive T in centrifugalization to each direction seems to be chiefly caused by the decrease or increase in the ventricle too. But moreover it may be partially due to the change of the heart position and especially in the exposure from head to tail the deficiency of coronary blood flow. 4) The depression of ST_II : It is regarded that the principal factor for the depression of ST under the isoelectric line in the exposure from head to tail is the coronary insufficiency or O_2 deficiency in the myocard owing to the decrease in venous return.

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Concerning the mutation of skincapillaries caused by the resection of carotidgland. For the purpose of reserching the relation between Carotidgland and vegetative nervous system, the author has made studies of skin-capillarskopic findings on the case of the following disease about the alteration by the resection of carotidgland. The results were as follows :- 1) Asthma bronchial : According to the classification of Iwanaga and Sugiura, in the 1st type was it found that the width of legs, width of loop were retrenched and got near to the healthy adults' results, and these alterations were remarkable by the resection of a one side carotidgland, but a greater difference could not be found by resection of both side. In the 2nd type, the variation of skincapillaries, caused by ressection of carotidgland, were very little. In the 3rd type, the width of legs, width of loop were recognized a close resemblance to the healthy adults' results, and the variation was not remarkable after one side resection, but became evident at the first time after both side resection. 2) Raynoud's disease : The singularity of skin-capillaries of this disease kept for a little while a tendency, approximate te the healthy adults' by the resection of carotidgland. 3) Rheumatoid Polyarthritis : The variation by the resection of Carotidgland was not found. Regarding the mutation, on the case of resection of Carotidgland, caused by the application of vegetative nervous poisons, warm and cold pressure test. 1) Asthma bronchial: In the 1st typs was it found that before the operation, was the variation by vegetative nervous poisons very mild, and the alteration by the resection of one side carotidgland was remarkable and got near to the healthy adults' results, but a greater difference could not be found by resection of both side. In the 2nd type was it found that the variation, which was mild by adrenalin, remarkable by atropin, before the operation, had not a change by resection of carotidgland. In the 3rd type, the variation, which was before the operation remarkable by adrenalin, mild by atropin, was recognized a close resemblance to the healthy adults' results at the first time after both side resection. 2) Reynaud's disease : The reverse reaction by vegetative nervous poisons disappeared after the resection of carotidgland. 3) Rheumatoid Polyarthritis : The variation by the resection of carotidgland got near to the healthy adults' results. 4) The mutation caused by the warm and cold pressure test on Reynaud's disease approximate to the healthyadults' by the resection of carotidgland. Concerning allergic disease and skin capillaries, and the mutation caused by vegetative nervous poisons. I have made statistic studies of skin-capillars-copic findings in comparing the data obtained on the 108 cases of allergic disease with those of the 110 healthy adults. The result showed : There were many cases having the finding of abnormal type of Muller, in the case of allergic disease, that is, in the healthy adults found it that 80 cases (73%) were normal type and 30 cases (27%) were abnormal type, but in allergic disease, 32 cases (30%) were normal type and 75 cases (70%) were abnormal type. According to the classification of the author, asthma bronchial and rheumatoid myocarditis have a majority in A type, Unticaria command a majority in B type and rheumatoid diathese have a majority in C type. About the operation of vegetative nervous poisons, I found that very remarkable alteration was seen by the use of atropin and the alteration by the use of adrenalin and pilocarpin was mild but the recovery was very sluggish. Regarding the mutation, on the case of tuber-culosis, caused by the application of vegetative nervous poisons. The study was made to reserch the change of Capillaries, affected with vegetative nervous poisons applied on tuberculosis. The result showed :

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Concerning the mutation of skincapillaries caused by the resection of carotidgland. For the purpose of reserching the relation between Carotidgland and vegetative nervous system, the author has made studies of skin-capillarskopic findings on the case of the following disease about the alteration by the resection of carotidgland. The results were as follows :- 1) Asthma bronchial : According to the classification of Iwanaga and Sugiura, in the 1st type was it found that the width of legs, width of loop were retrenched and got near to the healthy adults' results, and these alterations were remarkable by the resection of a one side carotidgland, but a greater difference could not be found by resection of both side. In the 2nd type, the variation of skincapillaries, caused by ressection of carotidgland, were very little. In the 3rd type, the width of legs, width of loop were recognized a close resemblance to the healthy adults' results, and the variation was not remarkable after one side resection, but became evident at the first time after both side resection. 2) Raynoud's disease : The singularity of skin-capillaries of this disease kept for a little while a tendency, approximate te the healthy adults' by the resection of carotidgland. 3) Rheumatoid Polyarthritis : The variation by the resection of Carotidgland was not found. Regarding the mutation, on the case of resection of Carotidgland, caused by the application of vegetative nervous poisons, warm and cold pressure test. 1) Asthma bronchial: In the 1st typs was it found that before the operation, was the variation by vegetative nervous poisons very mild, and the alteration by the resection of one side carotidgland was remarkable and got near to the healthy adults' results, but a greater difference could not be found by resection of both side. In the 2nd type was it found that the variation, which was mild by adrenalin, remarkable by atropin, before the operation, had not a change by resection of carotidgland. In the 3rd type, the variation, which was before the operation remarkable by adrenalin, mild by atropin, was recognized a close resemblance to the healthy adults' results at the first time after both side resection. 2) Reynaud's disease : The reverse reaction by vegetative nervous poisons disappeared after the resection of carotidgland. 3) Rheumatoid Polyarthritis : The variation by the resection of carotidgland got near to the healthy adults' results. 4) The mutation caused by the warm and cold pressure test on Reynaud's disease approximate to the healthyadults' by the resection of carotidgland. Concerning allergic disease and skin capillaries, and the mutation caused by vegetative nervous poisons. I have made statistic studies of skin-capillars-copic findings in comparing the data obtained on the 108 cases of allergic disease with those of the 110 healthy adults. The result showed : There were many cases having the finding of abnormal type of Muller, in the case of allergic disease, that is, in the healthy adults found it that 80 cases (73%) were normal type and 30 cases (27%) were abnormal type, but in allergic disease, 32 cases (30%) were normal type and 75 cases (70%) were abnormal type. According to the classification of the author, asthma bronchial and rheumatoid myocarditis have a majority in A type, Unticaria command a majority in B type and rheumatoid diathese have a majority in C type. About the operation of vegetative nervous poisons, I found that very remarkable alteration was seen by the use of atropin and the alteration by the use of adrenalin and pilocarpin was mild but the recovery was very sluggish. Regarding the mutation, on the case of tuber-culosis, caused by the application of vegetative nervous poisons. The study was made to reserch the change of Capillaries, affected with vegetative nervous poisons applied on tuberculosis. The result showed :

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Concerning the mutation of skincapillaries caused by the resection of carotidgland. For the purpose of reserching the relation between Carotidgland and vegetative nervous system, the author has made studies of skin-capillarskopic findings on the case of the following disease about the alteration by the resection of carotidgland. The results were as follows :- 1) Asthma bronchial : According to the classification of Iwanaga and Sugiura, in the 1st type was it found that the width of legs, width of loop were retrenched and got near to the healthy adults' results, and these alterations were remarkable by the resection of a one side carotidgland, but a greater difference could not be found by resection of both side. In the 2nd type, the variation of skincapillaries, caused by ressection of carotidgland, were very little. In the 3rd type, the width of legs, width of loop were recognized a close resemblance to the healthy adults' results, and the variation was not remarkable after one side resection, but became evident at the first time after both side resection. 2) Raynoud's disease : The singularity of skin-capillaries of this disease kept for a little while a tendency, approximate te the healthy adults' by the resection of carotidgland. 3) Rheumatoid Polyarthritis : The variation by the resection of Carotidgland was not found. Regarding the mutation, on the case of resection of Carotidgland, caused by the application of vegetative nervous poisons, warm and cold pressure test. 1) Asthma bronchial: In the 1st typs was it found that before the operation, was the variation by vegetative nervous poisons very mild, and the alteration by the resection of one side carotidgland was remarkable and got near to the healthy adults' results, but a greater difference could not be found by resection of both side. In the 2nd type was it found that the variation, which was mild by adrenalin, remarkable by atropin, before the operation, had not a change by resection of carotidgland. In the 3rd type, the variation, which was before the operation remarkable by adrenalin, mild by atropin, was recognized a close resemblance to the healthy adults' results at the first time after both side resection. 2) Reynaud's disease : The reverse reaction by vegetative nervous poisons disappeared after the resection of carotidgland. 3) Rheumatoid Polyarthritis : The variation by the resection of carotidgland got near to the healthy adults' results. 4) The mutation caused by the warm and cold pressure test on Reynaud's disease approximate to the healthyadults' by the resection of carotidgland. Concerning allergic disease and skin capillaries, and the mutation caused by vegetative nervous poisons. I have made statistic studies of skin-capillars-copic findings in comparing the data obtained on the 108 cases of allergic disease with those of the 110 healthy adults. The result showed : There were many cases having the finding of abnormal type of Muller, in the case of allergic disease, that is, in the healthy adults found it that 80 cases (73%) were normal type and 30 cases (27%) were abnormal type, but in allergic disease, 32 cases (30%) were normal type and 75 cases (70%) were abnormal type. According to the classification of the author, asthma bronchial and rheumatoid myocarditis have a majority in A type, Unticaria command a majority in B type and rheumatoid diathese have a majority in C type. About the operation of vegetative nervous poisons, I found that very remarkable alteration was seen by the use of atropin and the alteration by the use of adrenalin and pilocarpin was mild but the recovery was very sluggish. Regarding the mutation, on the case of tuber-culosis, caused by the application of vegetative nervous poisons. The study was made to reserch the change of Capillaries, affected with vegetative nervous poisons applied on tuberculosis. The result showed :

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Concerning the mutation of skincapillaries caused by the resection of carotidgland. For the purpose of reserching the relation between Carotidgland and vegetative nervous system, the author has made studies of skin-capillarskopic findings on the case of the following disease about the alteration by the resection of carotidgland. The results were as follows :- 1) Asthma bronchial : According to the classification of Iwanaga and Sugiura, in the 1st type was it found that the width of legs, width of loop were retrenched and got near to the healthy adults' results, and these alterations were remarkable by the resection of a one side carotidgland, but a greater difference could not be found by resection of both side. In the 2nd type, the variation of skincapillaries, caused by ressection of carotidgland, were very little. In the 3rd type, the width of legs, width of loop were recognized a close resemblance to the healthy adults' results, and the variation was not remarkable after one side resection, but became evident at the first time after both side resection. 2) Raynoud's disease : The singularity of skin-capillaries of this disease kept for a little while a tendency, approximate te the healthy adults' by the resection of carotidgland. 3) Rheumatoid Polyarthritis : The variation by the resection of Carotidgland was not found. Regarding the mutation, on the case of resection of Carotidgland, caused by the application of vegetative nervous poisons, warm and cold pressure test. 1) Asthma bronchial: In the 1st typs was it found that before the operation, was the variation by vegetative nervous poisons very mild, and the alteration by the resection of one side carotidgland was remarkable and got near to the healthy adults' results, but a greater difference could not be found by resection of both side. In the 2nd type was it found that the variation, which was mild by adrenalin, remarkable by atropin, before the operation, had not a change by resection of carotidgland. In the 3rd type, the variation, which was before the operation remarkable by adrenalin, mild by atropin, was recognized a close resemblance to the healthy adults' results at the first time after both side resection. 2) Reynaud's disease : The reverse reaction by vegetative nervous poisons disappeared after the resection of carotidgland. 3) Rheumatoid Polyarthritis : The variation by the resection of carotidgland got near to the healthy adults' results. 4) The mutation caused by the warm and cold pressure test on Reynaud's disease approximate to the healthyadults' by the resection of carotidgland. Concerning allergic disease and skin capillaries, and the mutation caused by vegetative nervous poisons. I have made statistic studies of skin-capillars-copic findings in comparing the data obtained on the 108 cases of allergic disease with those of the 110 healthy adults. The result showed : There were many cases having the finding of abnormal type of Muller, in the case of allergic disease, that is, in the healthy adults found it that 80 cases (73%) were normal type and 30 cases (27%) were abnormal type, but in allergic disease, 32 cases (30%) were normal type and 75 cases (70%) were abnormal type. According to the classification of the author, asthma bronchial and rheumatoid myocarditis have a majority in A type, Unticaria command a majority in B type and rheumatoid diathese have a majority in C type. About the operation of vegetative nervous poisons, I found that very remarkable alteration was seen by the use of atropin and the alteration by the use of adrenalin and pilocarpin was mild but the recovery was very sluggish. Regarding the mutation, on the case of tuber-culosis, caused by the application of vegetative nervous poisons. The study was made to reserch the change of Capillaries, affected with vegetative nervous poisons applied on tuberculosis. The result showed :

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In experimental myocardial infarction was observed the relationship between the initial deflection of ecg and histologioc findings. 1. Low voltage (under 0.5mV in all leads) was observed in cases, which myocardial damage were in the highst degree. 2. In the other cases, the changes of the initial deflection were variously. In the cases, which had aneurysma at the ventricular apex, the initial complexes deflected downwards, and not upwards in lead II and III. For detailed analysis of initial deflections were calculated the largest potentials (Φ_A) and their directions (θ_R) by means of orthogonal isoscale triangle coordinate (Maekawa). Results were as following. 3. In 5 cases (A-group), which Φ_A increased, was the extension of myocardial damage relatively localized and superficially. Φ_A increased immediately after the operation for the almost cases. The change of θ_R showed undetermined results compare with that before operation. 4. In 9 cases (B-group), which Φ_A decreased, the extension of myocardial damage excelled the apparent width. Histologic change was diffuse and reached to deep and degree of degeneration of myocardium was higher. Φ_A decreased immediately after the operation for the most cases. θ_R deviated to the right. 5. In the 6 cases (C-group), which Φ_A showed no remarkable change, was myocardial damage the same as A & B groups. The change of Φ_A in the cource of experiment and rotation of θ_R were variously in each cases. 6. In all cases, ecg were monophasic or biphasic in the sometime during the experiment. These results of the experiment showed that electrical change of the heart is produced by myocardium itself and its electrical potentials are representated as vectors directed from endcardium to epicardium according to excitement of myocardium. And so, ecg by limb lead represents rotation of a vector, which is resulted from those vectors. These facts give a experimental evidence to the "Chain-doublets" theory (Maekawa), that supposes the causality among the three physical phenomena, namely electricity, contraction and double refraction of myocardium.

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In experimental myocardial infarction was observed the relationship between the initial deflection of ecg and histologioc findings. 1. Low voltage (under 0.5mV in all leads) was observed in cases, which myocardial damage were in the highst degree. 2. In the other cases, the changes of the initial deflection were variously. In the cases, which had aneurysma at the ventricular apex, the initial complexes deflected downwards, and not upwards in lead II and III. For detailed analysis of initial deflections were calculated the largest potentials (Φ_A) and their directions (θ_R) by means of orthogonal isoscale triangle coordinate (Maekawa). Results were as following. 3. In 5 cases (A-group), which Φ_A increased, was the extension of myocardial damage relatively localized and superficially. Φ_A increased immediately after the operation for the almost cases. The change of θ_R showed undetermined results compare with that before operation. 4. In 9 cases (B-group), which Φ_A decreased, the extension of myocardial damage excelled the apparent width. Histologic change was diffuse and reached to deep and degree of degeneration of myocardium was higher. Φ_A decreased immediately after the operation for the most cases. θ_R deviated to the right. 5. In the 6 cases (C-group), which Φ_A showed no remarkable change, was myocardial damage the same as A & B groups. The change of Φ_A in the cource of experiment and rotation of θ_R were variously in each cases. 6. In all cases, ecg were monophasic or biphasic in the sometime during the experiment. These results of the experiment showed that electrical change of the heart is produced by myocardium itself and its electrical potentials are representated as vectors directed from endcardium to epicardium according to excitement of myocardium. And so, ecg by limb lead represents rotation of a vector, which is resulted from those vectors. These facts give a experimental evidence to the "Chain-doublets" theory (Maekawa), that supposes the causality among the three physical phenomena, namely electricity, contraction and double refraction of myocardium.

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In experimental myocardial infarction was observed the relationship between the initial deflection of ecg and histologioc findings. 1. Low voltage (under 0.5mV in all leads) was observed in cases, which myocardial damage were in the highst degree. 2. In the other cases, the changes of the initial deflection were variously. In the cases, which had aneurysma at the ventricular apex, the initial complexes deflected downwards, and not upwards in lead II and III. For detailed analysis of initial deflections were calculated the largest potentials (Φ_A) and their directions (θ_R) by means of orthogonal isoscale triangle coordinate (Maekawa). Results were as following. 3. In 5 cases (A-group), which Φ_A increased, was the extension of myocardial damage relatively localized and superficially. Φ_A increased immediately after the operation for the almost cases. The change of θ_R showed undetermined results compare with that before operation. 4. In 9 cases (B-group), which Φ_A decreased, the extension of myocardial damage excelled the apparent width. Histologic change was diffuse and reached to deep and degree of degeneration of myocardium was higher. Φ_A decreased immediately after the operation for the most cases. θ_R deviated to the right. 5. In the 6 cases (C-group), which Φ_A showed no remarkable change, was myocardial damage the same as A & B groups. The change of Φ_A in the cource of experiment and rotation of θ_R were variously in each cases. 6. In all cases, ecg were monophasic or biphasic in the sometime during the experiment. These results of the experiment showed that electrical change of the heart is produced by myocardium itself and its electrical potentials are representated as vectors directed from endcardium to epicardium according to excitement of myocardium. And so, ecg by limb lead represents rotation of a vector, which is resulted from those vectors. These facts give a experimental evidence to the "Chain-doublets" theory (Maekawa), that supposes the causality among the three physical phenomena, namely electricity, contraction and double refraction of myocardium.

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