Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Volume 34 , Issue 4
Showing 1-50 articles out of 82 articles from the selected issue
Highlight Review
  • Masaki Kita, Daisuke Uemura
    2005 Volume 34 Issue 4 Pages 454-459
    Published: 2005
    Released: February 26, 2005
    The discovery of new natural products frequently triggers a breakthrough in basic sciences. This review features marine iminium alkaloids, which control biologically and physiologically intriguing phenomena. Pinnatoxins, potent shellfish poisons purified from the Okinawan bivalve Pinna muricata, activate Ca2+ channels. Norzoanthamine hydrochloride, isolated from the colonial zoanthid Zoanthus sp., suppresses decreases in bone weight and strength in ovariectomized mice. Symbioimine, an amphoteric iminium metabolite from the dinoflagellate Symbiodinium sp., inhibits osteoclast differentiation. The latter two compounds are good candidates for antiosteoporotic drugs.