Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Volume 39 , Issue 11
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  • David Lapointe, Keith Fagnou
    2010 Volume 39 Issue 11 Pages 1118-1126
    Published: November 05, 2010
    Released: September 18, 2010
    JOURNALS OPEN ACCESS
    The cleavage of aromatic C–H bonds promoted by a metal and an intramolecular base has been described over 50 years ago. Herein, discussion of selected mechanistic studies of this transformation will be presented. The basic ligand on the metal was proven to play a pivotal role in the C–H bond cleavage step and evidence of a single operative concerted metallation–deprotonation mechanism unifies the different mechanistic studies.
    The cleavage of aromatic C–H bonds promoted by a metal and an intramolecular base has been described over 50 years ago. Herein, discussion of selected mechanistic studies provides a description of the concerted metallation–deprotonation (CMD) mechanism in the functionalization of heteroarene C–H bonds promoted by transition metals. Fullsize Image
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