Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Volume 41 , Issue 7
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Highlight Review
  • Minoru Ueda
    2012 Volume 41 Issue 7 Pages 658-666
    Published: July 05, 2012
    Released: June 23, 2012
    JOURNALS OPEN ACCESS
    Recent progress in chemical biology research has accelerated the target protein identification of biologically active small molecules, including naturally occurring ligands. It is widely recognized that a biologically active natural product functions as a “key” that fits a specific protein “lock.” However, recent studies have revealed multiligandable nature of natural products that works as “multiple keys” (or a “master key”) fitting multiple “locks” in a biological event. Biological experiments using natural products as ligands have often provided puzzling results, which can likely be attributed to their multiligandability. Thus, a novel research direction dealing with multiliganbale natural product ligand based on their target identification is strongly desired. This review focuses on the current status of natural products chemistry based on their target identification, and suggest the future direction, named chemical biological chemistry (Chem-Bio-Chem).
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