Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Volume 43 , Issue 11
Showing 1-44 articles out of 44 articles from the selected issue
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  • Osvaldo N. Oliveira, Jr., Tácito T. A. T. Neves, Fernando V. Pa ...
    2014 Volume 43 Issue 11 Pages 1672-1679
    Published: November 05, 2014
    Released: November 05, 2014
    [Advance publication] Released: September 05, 2014
    JOURNALS FREE ACCESS
    An overview is presented of the many opportunities and challenges for using “Big Data” concepts to treat data from chemical sensors. Issues discussed include the need to make data machine readable and how to integrate distinct types of data that can be acquired and stored in different places. As a concrete example of possible applications, we propose a framework for an expert system dedicated to clinical diagnosis, where data from various types of sensors can be combined with text to provide better-informed diagnostics.
    Framework of an expert system for clinical diagnosis, where computational methods of different kinds are integrated to exploit “Big Data” concepts. Datasets are expected to be obtained from the patient being considered and from a repository built for a large number of other patients. Such datasets will be obtained from chemical sensors, biosensors, imaging systems, and patient records. All of these data will be manipulated with a variety of methods indicated in the boxes of the flowchart, in order to reach an informed diagnostics. Fullsize Image
     
  • Koichiro Ishimori, Yuta Watanabe
    2014 Volume 43 Issue 11 Pages 1680-1689
    Published: November 05, 2014
    Released: November 05, 2014
    [Advance publication] Released: September 05, 2014
    JOURNALS FREE ACCESS
    Heme is a typical and common prosthetic group for various types of proteins and is utilized for active centers in many biologically important processes in vivo. However, heme has also been shown to function as a signaling molecule that regulates the functions of proteins, suggesting that novel signaling cascades are mediated by heme. We focused on the spectroscopic characterization of such “heme-regulated” proteins, showing unique heme environmental structures.
    Heme is a typical and common prosthetic group for various kinds of proteins, which is utilized for active centers in many biologically important processes in vivo. However, heme has also been shown to function as a signaling molecule that regulates the functions of the proteins, suggesting that novel signaling cascades mediated by heme. We focused on the spectroscopic characterization of such “heme-regulated” proteins showing the unique heme environmental structures. Fullsize Image
     
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Editor’s Choice
  • Xiao Zhang, Sadafumi Nishihara, Yuki Nakano, Kseniya Yu. Maryunina, Ka ...
    2014 Volume 43 Issue 11 Pages 1713-1715
    Published: November 05, 2014
    Released: November 05, 2014
    [Advance publication] Released: August 01, 2014
    JOURNALS OPEN ACCESS
    We succeeded in synthesizing a novel cuprate compound, [Cu2(CO3)2(bpp)2.5]·5.5H2O (1) (bpp: 1,3-bis(4-pyridyl)propane). Its structural determination reveals that 1 has a ladder-like configuration formed by the alternate stacking of two Cu2+ ions and a CO32− ion, each of which is linked by a bpp molecule. The results of magnetic susceptibility measurements indicate that the obtained magnetic susceptibility curve can be reproduced faithfully by a magnetically isolated spin ladder-based model with the ladder-rung magnetic interaction, Jrung/kB = 366 K and the ladder-leg interaction, Jleg/kB = 11.5 K, where J is defined as being positive (negative) for antiferromagnetic (ferromagnetic) interactions.
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