Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Volume 45 , Issue 3
Showing 1-43 articles out of 43 articles from the selected issue
Highlight Review
  • Huachao Chen, Danyang Liu, Zijian Guo
    2016 Volume 45 Issue 3 Pages 242-249
    Published: March 05, 2016
    Released: March 05, 2016
    [Advance publication] Released: January 23, 2016
    JOURNALS OPEN ACCESS
    Drug release in a spatially and temporally controlled manner is highly desired in the field of drug delivery. Endogenous stimuli-responsive nanocarriers provide significant advantages in maximizing the therapeutic efficacy and minimizing the side effects of loaded drugs. Biomarker-triggered release and site-specific delivery are the most commonly adopted strategies. In this review, the most recent advances in the field of endogenous stimuli-responsive drug delivery nanocarriers and their potential application in the treatment of various diseases are highlighted and discussed.
    A major challenge for drug delivery is to achieve spatially and temporally controlled drug release. Endogenous stimuli-responsive nanocarriers provide important tools for maximizing the therapeutic efficacy and minimizing the side effects of loaded drugs through biomarker-triggered release and site-specific targetting. In this review, the most recent advances in the field of endogenous stimuli-responsive drug delivery nanocarriers are highlighted and their potential application in the treatment of various diseases are presented and discussed. Fullsize Image
     
Letter
Editor’s Choice
  • Kenta Imoto, Shin-ichi Ohkoshi
    2016 Volume 45 Issue 3 Pages 359-361
    Published: March 05, 2016
    Released: March 05, 2016
    [Advance publication] Released: December 29, 2015
    JOURNALS OPEN ACCESS
    A cyanido-bridged Fe–Nb bimetal assembly, Fe2[Nb(CN)8](4-methylpyridine)8·2H2O, was synthesized. This compound exhibits a two-step spin-crossover phenomenon between FeII high-spin (FeIIHS, S = 2) and FeII low-spin (FeIILS, S = 0) at 112 and 95 K. Irradiation with 532-nm light converts the paramagnetic state to a ferrimagnetic state with a Curie temperature of 14 K and a coercive field of 2300 Oe. Furthermore, irradiating with 785-nm light reduces magnetization due to the reverse photoinduced spin-crossover phenomenon.
  • Moondra Zubir, Atom Hamasaki, Taku Iiyama, Akira Ohta, Hiroshi Ohki, S ...
    2016 Volume 45 Issue 3 Pages 362-364
    Published: March 05, 2016
    Released: March 05, 2016
    [Advance publication] Released: January 08, 2016
    JOURNALS OPEN ACCESS
    [Zn2(Oxac)(Taz)2]·(H2O)x, referred to as ZOTWx, was prepared from aqueous methanol solutions of Zn5(CO3)2(OH)6 and two kinds of ligands, 1,2,4-triazole (Taz) and oxalic acid (Oxac), at 453 K under magnetic fields of up to 6 T. The magnetic fields markedly changed the morphology from irregular agglomerates at zero field to rectangular-prism crystals having smooth surfaces at 6 T, although the monoclinic crystal structure was only slightly deformed to a triclinic one. As-synthesized ZOTWx(H) prepared under magnetic fields of H/T ≥ 2 adsorbed a large amount of N2 at 77 K in rectangular Type I adsorption isotherms even without the usual pretreatment at 383 K and 1 mPa. It suggests that high magnetic fields induced the formation of hydrophobic micropores having uniform sizes. The hydrophobicity was consistent with the results that the water-assisted micropore formation was depressed in the as-synthesized ZOTWx(H) containing a small amount of water.
Letter
feedback
Top