Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Volume 48 , Issue 8
Showing 1-50 articles out of 57 articles from the selected issue
Letter
Highlight Review
  • Masahide Terazima
    2019 Volume 48 Issue 8 Pages 802-810
    Published: August 05, 2019
    Released: August 05, 2019
    JOURNALS RESTRICTED ACCESS

    Proteins are flexible systems and their structures fluctuate at room temperature in aqueous solution due to the thermal energy. Although the role of conformational fluctuations in protein reactions has been an attractive and challenging subject to elucidate reaction mechanisms, there has been no direct experimental detection of such fluctuations during reactions. In this review, several time-resolved measurements of thermodynamic properties, which are directly linked to the fluctuation of proteins, are presented. In all cases, the fluctuations determined from the thermal expansion volume and the compressibility are enhanced in short-lived intermediates, and are well correlated with the reactivities. These results show that fluctuation is indeed key to understanding why some proteins can react without significant conformational changes.

    Although importance of fluctuation for protein reactions has been sometimes pointed out, there has been no evidence showing contribution to protein reactions. This highlight review describes the experimental measurements of conformational fluctuations for short-live species during protein reactions. The correlations between the fluctuations and the reactivities are described. Fullsize Image
     
  • Xue-Ru Zou, Shu-Mei Liao, Kuo-Wei Huang, Lan-Chang Liang
    2019 Volume 48 Issue 8 Pages 811-819
    Published: August 05, 2019
    Released: August 05, 2019
    JOURNALS RESTRICTED ACCESS

    The chemistry of anilido phosphine complexes has been popularized since 2003 when N-arylation of the parent o-anilinophosphine was made possible. This Highlight Review summarizes the cumulative progress made in nickel chemistry, paying particular attention to oxidative addition, reductive elimination, CO insertion, olefin insertion, β-hydrogen elimination, metathetical reaction, arene C-H activation, and their collaborative applications to Kumada-type cross coupling catalysis.

    The chemistry of anilido phosphine complexes has been popularized since 2003 when Narylation of the parent o-anilinophosphine was made possible. This Highlight Review summarizes the cumulative progress made in nickel chemistry, paying particular attention to oxidative addition, reductive elimination, CO insertion, olefin insertion, β-hydrogen elimination, metathetical reaction, arene C-H activation, and their collaborative applications to Kumada-type cross coupling catalysis. Fullsize Image
     
Letter
Highlight Review
  • Ryo Takahata, Tatsuya Tsukuda
    2019 Volume 48 Issue 8 Pages 906-915
    Published: August 05, 2019
    Released: August 05, 2019
    JOURNALS RESTRICTED ACCESS

    Ultrathin gold nanowires (AuUNWs) and nanorods (AuUNRs) with diameters smaller than the critical dimension for quantization (∼2 nm), are a new class of anisotropic nanostructures. Due to their unique morphologies and specific electronic, optical, and mechanical properties, they hold promise for future application in strain sensors, photovoltaic and light-emitting diode devices, and catalysts. In this highlight review, we provide an overview of the current status and future prospects of their controlled syntheses, a characterization of their atomic structures and physicochemical and thermodynamic properties, and their usage in the fabrication of advanced devices.

    Ultrathin gold nanowires and nanorods with diameters smaller than the critical dimension for quantization (~2 nm), are a new class of anisotropic nanostructures. This highlight review will focus on the current status and future prospects of their controlled syntheses, a characterization of their atomic structures and physicochemical and thermodynamic properties, and their usage in the fabrication of advanced devices. Fullsize Image
     
  • Rianne M. Lord, Patrick C. McGowan
    2019 Volume 48 Issue 8 Pages 916-924
    Published: August 05, 2019
    Released: August 05, 2019
    JOURNALS RESTRICTED ACCESS

    In the past decade, libraries of iridium organometallic arene compounds have expanded rapidly, with the majority of their applications aimed towards effective catalysts and potential anti-cancer drug candidates. Researchers have begun to adapt the traditional “piano-stool” structures to include different bidentate ligands, ancillary ligands and extend the aromaticity and functionality of the arene substituent, all in the hope to optimize their activities and allow the determination of structure activity relationships. Many of the complexes incorporate N- and O-donor ligands, but more recently, these structures have been expanded to include C-donor ligands such as cyclometalated bidentate ligands and N-heterocyclic carbenes. This mini-review highlights the recent and ongoing research in C-donor iridium arene complexes, and discusses their importance as potential anticancer drugs.

    To date, the most effective iridium anticancer compounds are those with “piano-stool” structures and which usually incorporate a variety of N-, O-, S- and P-bidentate ligands. These compounds can be easily functionalized by changing the bidentate ligands, the ancillary ligands and increasing the aromaticity of the arene substituent, all in the hope to optimize their activities and allow the determination of structure activity relationships. However, research towards C-donor ligands has only just emerged in the past 5 years, with cyclometalated and N-heterocyclic carbene iridium complexes showing significant increases in potency towards a range of cancer cell lines. This mini-review highlights the recent and ongoing research in C-donor iridium organometallic complexes, and herein we discuss their importance as potential anticancer drugs. Fullsize Image
     
Letter
Highlight Review
  • Geewoo Nam, Mi Hee Lim
    2019 Volume 48 Issue 8 Pages 951-960
    Published: August 05, 2019
    Released: August 05, 2019
    JOURNALS RESTRICTED ACCESS

    Both amyloid-β (Aβ) and metal ions are implicated in the pathology of Alzheimer’s disease (AD). Research efforts elucidating the pathogenic roles of these two biological components denote a connection between them. This highlight review presents the current understanding of Aβ and metal ions in AD and their relationship prompting a hybrid concept: metal-bound Aβ (metal–Aβ).

    Both amyloid-β (Aβ) and metal ions are implicated in the pathology of Alzheimer’s disease (AD). Research efforts elucidating the pathogenic roles of these two biological components denote a connection between them. This highlight review presents the current understanding of Aβ and metal ions in AD and their relationship prompting a hybrid concept: metal-bound Aβ (metalAβ). Fullsize Image
     
Letter
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