Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Volume 50 , Issue 3
Showing 1-27 articles out of 27 articles from the selected issue
Vol. 50 Commemorative Highlight Review
  • Tomohiro Shiraki
    2021 Volume 50 Issue 3 Pages 397-404
    Published: March 05, 2021
    Released: March 06, 2021
    JOURNALS RESTRICTED ACCESS

    Local chemical functionalization of single-walled carbon nanotubes (SWCNTs) has been developed as a means of defect doping to enhance the near infrared photoluminescence properties of the materials. Wavelength-tunable and exciton trapping-induced bright emission appears from locally functionalized SWCNTs (lf-SWCNTs). Molecularly designed lf-SWCNTs based on our approach produce new dynamic switching functionalities and greater shifts of the emission wavelength, which gives unique exciton properties to lf-SWCNTs.

    Local chemical functionalization of single-walled carbon nanotubes (SWCNTs) has been developed as a means of defect doping to enhance the near infrared photoluminescence properties of the materials. Wavelength-tunable and exciton trapping-induced bright emission appears from locally functionalized SWCNTs (lf-SWCNTs). Molecularly designed lf-SWCNTs based on our approach produce new dynamic switching functionalities and greater shifts of the emission wavelength, which gives unique exciton properties to lf-SWCNTs. Fullsize Image
     
  • Xia Wu, Xunwu Hu, Ye Zhang
    2021 Volume 50 Issue 3 Pages 405-410
    Published: March 05, 2021
    Released: March 06, 2021
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    Molecular assembly is a widely applied synthetic strategy for the construction of multimolecular architecture at a nanoscale or microscale that can simultaneously target numerous components. Upon the control over size, shape, valency, etc., molecular assembly can fulfill demands to regulate cellular responses even cell fate by approaching different cellular sub-organelles as potential cancer therapy.

    Upon the control over size, shape, valency, etc., molecular assembly can fit the demands to regulate cellular responses even cell fate by approaching different cellular suborganelles as potential cancer therapy. Fullsize Image
     
  • Tsuyoshi Nishikawa, Makoto Ouchi
    2021 Volume 50 Issue 3 Pages 411-417
    Published: March 05, 2021
    Released: March 06, 2021
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    In chain-growth polymerization, the polymerization behaviors are governed by the nature of monomer depending on the side-chain structure (e.g. conjugated/non-conjugated, electron-rich/deficient), leading to limitations in (co)polymers we can synthesize. This highlight review summarizes recent development in polymer reactions to overcome such limitations. The key is the design of transformable monomers as well as the utilization of novel organic transformations.

    In chain-growth polymerization, the polymerization behaviors are governed by the nature of monomer depending on the side-chain structure (e.g. conjugated/nonconjugated, electron-rich/deficient), leading to limitations in (co)polymers we can synthesize. This highlight review summarizes recent development in polymer reactions to overcome such limitations. The key is the design of transformable monomers as well as the utilization of novel organic transformations. Fullsize Image
     
  • Teng Ma, Madoka Sato, Maki Komiya, Xingyao Feng, Daisuke Tadaki, Ayumi ...
    2021 Volume 50 Issue 3 Pages 418-425
    Published: March 05, 2021
    Released: March 06, 2021
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    Because of their unique structures and properties, self-assembled bilayer lipid membranes are a subject of intense interest. In this Highlight Review, we summarize recent progress made in research related to bilayer lipid membranes, including the formation of stable free-standing lipid membranes, applications of artificial lipid bilayers as a model cell membrane to study biological processes, and new bio-hybrid devices based on bilayer lipid membranes.

    In this Highlight Review, we summarize recent progress made in research related to bilayer lipid membranes, including the formation of stable free-standing lipid membranes, applications of artificial lipid bilayers as a model cell membrane to study biological processes, and new bio-hybrid devices based on bilayer lipid membranes. Fullsize Image
     
Letter
Vol. 50 Commemorative Highlight Review
  • Shinya Kimura, Masashi Yokoya, Masamichi Yamanaka
    2021 Volume 50 Issue 3 Pages 459-466
    Published: March 05, 2021
    Released: March 06, 2021
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    Rational molecular design enables the development of stimuli-responsive supramolecular hydrogels. Biocompatible supramolecular hydrogels have great potential for medicinal and pharmaceutical applications. In this review, we focus on supramolecular hydrogels, which show gel-to-sol phase transitions in response to biological-stimuli, and biological-stimuli-induced supramolecular hydrogel formations.

    Rational molecular design enables the development of stimuli-responsive supramolecular hydrogels. Biocompatible supramolecular hydrogels have great potential for medicinal and pharmaceutical applications. In this review, we focus on supramolecular hydrogels, which show gel-to-sol phase transitions in response to biological stimuli, and biological stimuli-induced supramolecular hydrogel formations. Fullsize Image
     
Letter
Vol. 50 Commemorative Highlight Review
  • Seijiro Matsubara
    2021 Volume 50 Issue 3 Pages 475-481
    Published: March 05, 2021
    Released: March 06, 2021
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    The core technologies of fully automated organic synthesis include the management of large amounts of accumulated reaction examples, machine learning based on these experimental results, and subsequent development of synthesis devices. Digitization of organic synthesis is key in progressing towards full automation. Various attempts at digitization are already enabling the development of a framework, in which the input of a molecular structure is converted into actual molecular synthesis.

    The core technologies of fully automated organic synthesis include the management of large amounts of accumulated reaction examples, machine learning based on these experimental results, and subsequent development of synthesis devices. Digitization of organic synthesis is key in progressing towards full automation. Various attempts at digitization are already enabling the development of a framework, in which the input of a molecular structure is converted into actual molecular synthesis. Fullsize Image
     
Letter
Vol. 50 Commemorative Highlight Review
  • Aiichiro Nagaki, Yosuke Ashikari, Masahiro Takumi, Takashi Tamaki
    2021 Volume 50 Issue 3 Pages 485-492
    Published: March 05, 2021
    Released: March 06, 2021
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    Organolithium reagents are often too unstable to use due to being highly reactive. This limits their application in organic synthesis. This review highlights our approach to various synthetic reactions mediated by organolithium reagents based on flash chemistry conducted in flow reactors, especially utilizing space-integration of the flow reactions.

    The high reactivity of organolithiums often renders them too unstable to use, thereby limiting their application in organic synthesis. This review highlights our approaches for synthetic reactions mediated by organolithiums based on Flash chemistry in flow reactors, especially utilizing space-integration of flow reactions. Fullsize Image
     
Letter
Vol. 50 Commemorative Highlight Review
  • Dongsheng Xue, Haibing He, Shuanhu Gao
    2021 Volume 50 Issue 3 Pages 497-502
    Published: March 05, 2021
    Released: March 06, 2021
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    Furanosteroids are polycyclic natural products isolated from fungus, which consist of wortmannin and viridin containing a [5,6,6,6]-tetracyclic skeleton in addition to a furan ring. They inhibit phosphoinositide 3-kinases, suggesting drug potential. This highlight review describes strategies that have been reported for building the tetracyclic ring skeleton and the all-carbon quaternary center in order to achieve total syntheses of wortmannin and viridin.

    Furanosteroids are polycyclic natural products isolated from fungus, which consist of wortmannin and viridin containing a [5,6,6,6]-tetracyclic skeleton in addition to a furan ring. They inhibit phosphoinositide 3-kinases, suggesting drug potential. This highlight review describes strategies that have been reported for building the tetracyclic ring skeleton and the all-carbon quaternary center in order to achieve total syntheses of wortmannin and viridin. Fullsize Image
     
  • Masato Komoda, Yuta Nishina
    2021 Volume 50 Issue 3 Pages 503-509
    Published: March 05, 2021
    Released: March 06, 2021
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    Oxidation of graphite is widely recognized as a promising method for large-scale production of graphene-like materials. Chemical oxidation of graphite has been developed for more than 100 years, while electrochemical oxidation has attracted attention over the last 10 years as a simple, safe, and controllable production method for graphene. This review summarizes the electrochemical production of graphene analogs focusing on the electrochemical conditions and form of starting graphite that affect the properties of the products. Electrochemical treatment of graphite by direct current has been applied to various graphite, such as HOPG, graphite rod, graphite foil, and powdered graphite, and generates deeply oxidized graphene materials. On the other hand, treatments with alternative current generate low oxygen content products. Therefore, the electrochemical treatment of graphite provides an option for the controlled production of graphene-like materials.

    Electrochemical exfoliation of graphite has attracted attention over the last 10 years due to its simple, safe, and controllable characteristics. This review classifies the electrolysis of graphite according to the shape, size, and crystallinity of raw materials, and provide engineering insight into approaching the practical application of graphene. Fullsize Image
     
Letter
Vol. 50 Commemorative Highlight Review
  • Yoshinobu Kamakura, Daisuke Tanaka
    2021 Volume 50 Issue 3 Pages 523-533
    Published: March 05, 2021
    Released: March 06, 2021
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    Metal–organic frameworks (MOFs) or coordination polymers (CPs) with metal–sulfur bonds in their secondary building units (SBUs), are promising materials for use in semiconductors, conductivity applications, and photocatalysis. This review describes synthetic approaches to obtain highly crystalline samples, in addition to a discussion of the dimensionalities of the SBUs and the functionalities of sulfur-based CPs/MOFs.

    Metal-organic frameworks (MOFs) or coordination polymers (CPs) are composed of secondary building units (SBUs) and organic linker. Oxygen is the successful coordinated anion. Recently, sulfur is used as the coordinated anion in SBU, and sulfur-based MOFs and CPs have been attracted as unique materials. In this highlight review, the development of sulfur-based MOFs and CPs are introduced. Fullsize Image
     
Letter
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