Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
最新号
選択された号の論文の26件中1~26を表示しています
Highlight Review
  • Toshio Naito
    2018 年 47 巻 12 号 p. 1441-1452
    発行日: 2018/12/05
    公開日: 2018/12/05
    ジャーナル 認証あり

    Molecular crystals are among the states of matter containing the largest number of thermodynamic degrees of freedom concerning spin, charge, orbital, and structure. However, many of them cannot be fully controlled to realize the unique physical properties and novel electronic states because of the thermodynamic instability of the molecular crystals. We will review here the evidence that optical excitation is a powerful tool, independent of thermodynamic conditions, to realize unique physical properties and electronic states otherwise unrealized.

    We shall review an optical control method that realizes unique electrical and magnetic properties that cannot be realized by any other method in an instant and reversible way. The figure here shows the molecular orbitals and the electron spin resonance spectra for a copper (II) complex under dark conditions and under UV irradiation. The red spectrum (UV) demonstrates that the complex possesses localized unpaired electrons around the copper (II) ions along with delocalized (dark) unpaired electrons. The mixing ratio between the two types of unpaired electrons can be controlled by irradiation conditions, while such an electronic state cannot be realized by chemical modification at any temperature or pressure. Fullsize Image
     
  • Qiao-Ying Li, Bi-Feng Yuan, Yu-Qi Feng
    2018 年 47 巻 12 号 p. 1453-1459
    発行日: 2018/12/05
    公開日: 2018/12/05
    ジャーナル 認証あり

    Over 150 different types of modifications have been found in nucleic acids so far. The modification in nucleic acids now is recognized as a new layer in regulating gene expression. Elucidation of the functional roles of these modifications is critical to understand living organisms and the molecular mechanism of diseases. The abundance of most of the modifications is extremely low. Thus, deciphering the biological roles of these modifications requires sensitive analytical methods. In recent years, substantial advances have been achieved in the development of analytical strategies and methods for determining and quantifying nucleic acid modifications. Owing to the good detection sensitivity and capability in qualitative analysis of modifications, mass spectrometry (MS) has been widely employed in studying nucleic acid modifications. Here we review the recent MS-based methodological advances, with more focus on the chemical derivatization in conjugation with MS detection for analyzing nucleic acid modifications.

    The modification in nucleic acids can function as additional layer of information carrier on regulating gene expression. Elucidation of the biological roles of these modifications relies on the accurate analysis of the modifications. Here we review the recent mass spectrometrybased methodological advances, with more focus on the chemical derivatization in conjugation with mass spectrometry detection for analyzing nucleic acid modifications. Fullsize Image
     
Letter
feedback
Top