Initial signs of patients with posterior cortical atrophy (PCA) can be easily overlooked when compared with those with other degenerative diseases, e.g., primary progressive aphasia and behavior variant frontotemporal dementia. However, PCA patients shows significantly great impairment in everyday skills required at the workplace and at home. In this study, we described the initial signs of seven patients with PCA in the author’s clinics in detail. In addition, we reviewed the initial signs in the past case reports on PCA, which included 70 patients with PCA. We found that more than 70 percent of PCA patients showed visuospatial deficits, followed by difficulties in reading, driving, and dressing, all of which were likely related to visuospatial deficits. Visual agnosia, agraphia, acalculia, and impairments of vision, e.g., visual field deficits, blurred vision, or visual hallucinations, are also found in some patients. These results indicated that visuospatial deficits are the hallmark in PCA patients, which affect everyday skills, such as locating, arrangement, reading, driving, dressing, eating, cooking, and operating.