Chemical and Pharmaceutical Bulletin
日本薬学会は,1880年に創立された,我が国では歴史ある学会の一つです.現在,約17000人の会員を擁しており,毎月3誌の学術誌を刊行しております.英文による学術誌の一つとして「Chemical and Pharmaceutical Bulletin」(Chem. Pharm. Bull.)は, 1953年にPharmaceutical Bulletinとして創刊され,その後Chem. Pharm. Bull. と名称を変え,薬学と健康科学に関する化学分野をカバーしています.二つ目として,「Biological and Pharmaceutical Bulletin」(Biol. Pharm. Bull.) があり,これは1978年に創刊されたJournal Pharmacobio-Dynamicsを起源としており,更に1953年に創刊され,2012年に内容を引き継いだJournal of Health Scienceの後継誌として,薬学と健康科学に関する生物学分野を領域としています.英文と和文両方にて構成される学術誌として,「YAKUGAKU ZASSHI」(薬学雑誌)があり,本学術誌は学会創立の翌年(1881年)に創刊され,最も長い歴史を有しています.薬学雑誌では,和文による原著論文・総説等のほか,臨床薬学領域研究については英文による投稿も受け付けています. 日本薬学会におけるこれら学術誌のスコープは,基礎研究から臨床研究に至る幅広い分野に渡りますが,いずれも薬学・健康科学をベースとしています。3誌に投稿された論文の平均審査期間は,現在,投稿された方へ最初の判定を通知するまでに約1か月ですが,更なる時間短縮を目指しています.3誌ともにJ-STAGEにて無料公開しており,研究成果を世に広める一助となることを期待しております.皆様の研究成果をChem. Pharm. Bull.やBiol. Pharm. Bull.,薬学雑誌へ積極的にご投稿下さいますよう,よろしくお願い申し上げます.

学術誌編集委員長
大槻 純男
熊本大学大学院生命科学研究部



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収録数 27,776本
(更新日 2021/06/15)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
1.416
2019 Journal Impact Factor (JIF)
ジャーナル 査読 フリー HTML 早期公開
Scopus Pubmed
おすすめ記事
69 巻 (2021) 6 号 p. 503-515
Target Protein-Oriented Isolations for Bioactive Natural Products もっと読む
編集者のコメント

Structure and bioactivities of natural products are often beyond human knowledge and imagination. In this article, the author developed original screening methods based on protein binding activity. Protein beads method and protein plate method were described. Protein beads method led to the discovery of neural stem cell differentiation activators which inhibited Hes1 dimer formation as a new mechanism. The author also developed protein plate method for protein-protein interaction inhibitors to find new cancer drug candidates. Because protein binding ability is tightly related to bioactivity, protein-based natural products isolation is a powerful means to find new candidate medicines.

69 巻 (2021) 6 号 p. 516-525
Development of Catalytic Reactions for Precise Control of Chemoselectivity もっと読む
編集者のコメント

A cooperative catalyst comprising a soft Lewis acid/hard Brønsted base enabled chemoselective activation of a hydroxyl group over an amino group. The present chemoselective catalysis could be applicable for a variety of amino alcohols, including pharmaceuticals, without requiring a tedious protection-deprotection process. Chemoselective enolization and subsequent α-functionalization of carboxylic acid derivatives were also achieved by a redox active catalyst through the radical process, providing unnatural α-amino/hydroxy acid derivatives bearing a complex carbon framework and a diverse set of functionalities. The present chemoselective catalysis described herein offers new opportunities to expand the chemical space for innovative drug discovery research.

69 巻 (2021) 6 号 p. 526-528
Fluorescent-Oxaboroles: Synthesis and Optical Property by Sugar Recognition もっと読む
編集者のコメント

The optical property of fluorescent unit-conjugated aliphatic oxaboroles has been investigated in this featured article. The authors described the synthesis of fluorescent-oxaboroles by originally developed methods and the optical behavior of the boroles with various sugars. The oxaboroles provide good fluorescence quantum yields and selective recognition toward D-ribose and D-ribose-containing molecules. The molecular recognition induced significant fluorescence quenching. The authors also revealed the positive correlation between the LUMO energy of the oxaborole and the relative fluorescence intensity. The property of the boroles showed the possibility of the boron-based NAD sensor probe.

69 巻 (2021) 6 号 p. 537-547
A New Bitterness Evaluation Index Obtained Using the Taste Sensor for 48 Active Pharmaceutical Ingredients of Pediatric Medicines もっと読む
編集者のコメント

Quantitative evaluation for bitterness of pediatric medicine is essential for adherence.  The authors proposed criteria, change in concentration-dependent potential (CCDP), dose-response slope of the sensor outputs of active pharmaceutical ingredients measured by an artificial taste sensor, which is new and useful bitterness evaluation index for 48 pediatric medicines from the recent edition of the WHO model list of essential medicines for children (7th ed., 2019). CCDP by individual basic bitterness sensor well correlated to various physicochemical factors related hydrophilicity and hydrophobicity. Therefore, CCDP proved to be useful as a bitterness evaluation index of APIs in pediatric medicines.

69 巻 (2021) 6 号 p. 564-572
Discoveries and Syntheses of Highly Potent Antimalarial Troponoids もっと読む
編集者のコメント

Novel 25 derivatives of puberulic acid were synthesized by utilizing the authors’ total synthetic route. According to previous structure-activity relationships information, they focused on the carboxylic acid moiety in puberulic acid and converted it into the corresponding esters, amides and ketones. Antimalarial evaluations in vitro and in vivo of these derivatives were carried out and revealed detailed SAR information. It was clarified that several ester and ketone derivatives conserve strong antimalarial activity similar to that of puberulic acid without any obvious toxicity in oral dose of 15 mg/kg.

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発行機関からのお知らせ
  • Announcement of Academic Journals’ Awards Chemical and Pharmaceutical Bulletin (CPB)
    https://cpb.pharm.or.jp/award/award.pdf
  • Chem. Pharm. Bull. Vol. 69 No. 1
    Current Topics: Pharmaceutical Research for Quality Evaluation and Characterization of Foods and Natural Products
  • Chem. Pharm. Bull. Vol. 68 No. 12
    Current Topics: New Era of Polyphenol Research
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