Chemical and Pharmaceutical Bulletin
日本薬学会は,1880年に創立された,我が国では歴史ある学会の一つです.現在,約15,000人の会員を擁しており,毎月3誌の学術誌を刊行しております.英文による学術誌の一つとして「Chemical and Pharmaceutical Bulletin」(Chem. Pharm. Bull.)は, 1953年にPharmaceutical Bulletinとして創刊され,その後Chem. Pharm. Bull. と名称を変え,薬学と健康科学に関する化学分野をカバーしています.二つ目として,「Biological and Pharmaceutical Bulletin」(Biol. Pharm. Bull.) があり,これは1978年に創刊されたJournal Pharmacobio-Dynamicsを起源としており,更に1953年に創刊され,2012年に内容を引き継いだJournal of Health Scienceの後継誌として,薬学と健康科学に関する生物学分野を領域としています.英文と和文両方にて構成される学術誌として,「YAKUGAKU ZASSHI」(薬学雑誌)があり,本学術誌は学会創立の翌年(1881年)に創刊され,最も長い歴史を有しています.薬学雑誌では,和文による原著論文・総説等のほか,臨床薬学領域研究については英文による投稿も受け付けています. 日本薬学会におけるこれら学術誌のスコープは,基礎研究から臨床研究に至る幅広い分野に渡りますが,いずれも薬学・健康科学をベースとしています。3誌に投稿された論文の平均審査期間は,現在,投稿された方へ最初の判定を通知するまでに約1か月ですが,更なる時間短縮を目指しています.3誌ともにJ-STAGEにて無料公開しており,研究成果を世に広める一助となることを期待しております.皆様の研究成果をChem. Pharm. Bull.やBiol. Pharm. Bull.,薬学雑誌へ積極的にご投稿下さいますよう,よろしくお願い申し上げます.

学術誌編集委員長
大槻 純男
熊本大学大学院生命科学研究部
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収録数 28,149本
(更新日 2023/09/27)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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2022 Journal Impact Factor (JIF)
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おすすめ記事
71 巻 (2023) 9 号 p. 687-694
Effects of Granulated Lactose Characteristics and Lubricant Blending Conditions on Tablet Physical Properties in Direct Powder Compression もっと読む
編集者のコメント

This study evaluated the effects of different forms of granulated lactose (GL) on the physical properties of tablets and the effect of magnesium stearate on each type of GL. The different forms of GL such as agitated granulation (GL-AG), spray-dried granulation (GL-SD), and fluidized bed granulation (GL-FB) were added as excipients during direct powder compression. When tablets with the same blending conditions were compared, the tensile strength and disintegration time followed the order as GL-FB > GL-SD > GL-AG. The authors presented selection criteria for the suitability of different forms of GL during tableting by examining the relevance between the type of GL and properties of the tablets produced.

71 巻 (2023) 9 号 p. 701-716
Synthesis and Evaluation of Novel Triaryl Derivatives with Readthrough-Inducing Activity もっと読む
編集者のコメント

Readthrough therapy, which restores the biosynthesis of full-length proteins by incorporating an amino acid at a premature termination codon and allowing translation to continue, has recently been actively investigated for its application to nonsense mutation-related diseases. In this article, triaryl derivatives were synthesized and evaluated for the development of novel readthrough agents to treat mucopolysaccharidosis type I, which is caused by nonsense mutations in the IDUA gene. KY-516, a representative compound, exhibited excellent readthrough-inducing activity in the luciferase assay and significantly increased enzyme activity in mutant IDUA transgenic cells.

71 巻 (2023) 9 号 p. 717-723
Synthesis of New 26,27-Difluoro- and 26,26,27,27-Tetrafluoro-25-hydroxyvitamin D3: Effects of Terminal Fluorine Atoms on Biological Activity and Half-life もっと読む
編集者のコメント

In this Article, the authors investigated the effects of fluorine atoms introduced to the terminal positions of the side chain (26 and 27-positions) of 25-hydroxyvitamin D3 (25(OH)D3) on vitamin D receptor (VDR) binding affinity, osteocalcin promoter transactivation activity, and levels of resistance against CYP24A1-dependant metabolism. They revealed that these biological activities were enhanced in the order of 26,27-difluoro, 26,26,27,27-tetrafluoro, and 26,26,26,27,27,27-hexafluoro-25(OH)D3. Introduction of fluorines at these positions lead to improvements on functions as VDR-ligands and biological activity. With regard to the VDR binding affinity, the authors considered those potency improvements might be attributed to the increased acidity of the 25-OH group.

71 巻 (2023) 9 号 p. 730-733
Synthesis and in Vitro Cytotoxicity Evaluation of Jadomycins もっと読む
編集者のコメント

The authors synthesized jadomycins and their structural analogues, evaluated their cytotoxic activity, and addressed structure-activity relationship study of jadomycins. They achieved the total synthesis of jadomycin T and jadomycin aglycons using L-threonine and 1-amino-2-propanol as nitrogen sources. When the cytotoxicity of jadomycins were evaluated in several tumor cells, the jadomycin aglycons tended to be more cytotoxic than the jadomycins. The authors also demonstrated the potential application of jadomycins as lead compounds for the treatment of brain tumors. This paper provides important insights into the total synthesis of other natural organic compounds, structure-activity relationship studies, and development of new therapeutic drugs.

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  • Chem. Pharm. Bull. Vol. 71 No. 7
    Current Topics: Development of Naturally Occurring Compounds for the Treatment of Intractable Diseases
  • Chem. Pharm. Bull. Vol. 71 No. 6
    Current Topics: In Silico Technologies to Boost Pharmaceutical Development
  • Announcement of Academic Journals’ Awards Chemical and Pharmaceutical Bulletin (CPB)
    https://cpb.pharm.or.jp/award/award.pdf
  • Chem. Pharm. Bull. Vol. 71 No. 2
    Current Topics: Transition Metal Catalysis Research in Pharmaceutical Organic Chemistry
  • Chem. Pharm. Bull. Vol. 71 No. 1
    Current Topics: Applications of Fluorescence Detection in Current Pharmaceutical Research
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