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Volume 10, Issue 7
Displaying 1-26 of 26 articles from this issue
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Akira Yamamoto, Hidetoshi Yoshimura, Hisao Tsukamoto1962 Volume 10 Issue 7 Pages 540-544
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe structures of three metabolites isolated from the urine of rabbits and dogs admintstered with meprobamate (2-methyl-2-n-propyl-1, 3-propanediol dicarbamate) were established as keto-meprobamate [2-methyl-2-(2-oxo-propyl)-1, 3-propanediol dicarbamate], hydroxy-meprobamate [2-methyl-2-(2-hydroxypropyl)-1, 3-propanediol dicarbamate] and carboxy-meprobamate [2-methyl-2-(2-carboxyethyl)-1, 3-propanedioi dicarbamate].View full abstractDownload PDF (870K) -
Organic Analysis. XXXIII. Mechanism of the Color Reaction between Fructose and N-MethyldiphenylamineTsutomu Momose, Masaru Nakamura1962 Volume 10 Issue 7 Pages 544-546
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe main dye of the color reaction between fructose and N-methyldiphenylamine was isolated in crystalline form as its chloride and sulfate. Its probable structure was presented and the reaction mechanism was assumed as the same as in the reaction of fructose with diphenylamine.View full abstractDownload PDF (434K) -
Tsutomu Momose, Yo Ueda, Masatake Iwasaki1962 Volume 10 Issue 7 Pages 546-549
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe main coloring matters of the fused reaction of glucoronic acid with 1, 3-naphthalenediol were isolated in crystalline form as their methyl ethers. Two of them were identified as the dyes produced in the Tollens reaction. The structures of two new dyes were presented, and the reaction mechanism was discussed.View full abstractDownload PDF (563K) -
Tsutomu Momose, Yosuke Ohokura1962 Volume 10 Issue 7 Pages 550-553
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSTri(6-thymolyl)methane and di (6-thymolyl) methane were isolated from the colored reaction mixture of hexose with thymol in sulfuric acid. The former compound was also isolated from the reaction mixture of thymol with 5-hydroxymethylfurfural or formaldehyde. The mechanism of the color reaction was discussed.View full abstractDownload PDF (733K) -
Tsutomu Momose, Masaru Nakamura1962 Volume 10 Issue 7 Pages 553-555
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESS3, 6-Dinitrophthalic acid proved to be a useful reagent for the identification of aliphatic and aromatic amines as their salts.View full abstractDownload PDF (466K) -
Hisashi Tanaka, Akira Yokoyama1962 Volume 10 Issue 7 Pages 556-562
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSAmides of β-mercaptohydrocinnamic acid were prepared by the addition of hydrogen sulfide to amides of cinnamic acid. Amides of thiosalicylic acid were also prepared. Some of these mercapto-amides formed stable chelates with copper and nickel. Cobalt chelate was not stable enough to be separated in pure state. The ratio of the ligand to the metal was 1:1 in copper chelate and 2:1 in nickel chelate. It was found that these chelate compounds were S-O chelating compounds from the infrared spectra.View full abstractDownload PDF (924K) -
Masuo Akagi, Setsuzo Tejima, Masanobu Haga1962 Volume 10 Issue 7 Pages 562-566
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESS66-Deoxy-6-thio-D-glucose was prepared by hydrolysis of 6-deoxy-6-mercapto-6-Sacety1-1, 2, 3, 4-tetra-O-acetyl-β-D-glucopyranose and 6-deoxy-6-mercapto-6-S-acety1-1, 2-O-isopropylidene-3, 5-benzylidene-α-D-glucofuranose which were synthesized from corresponding 6-p-toluenesulfonyl derivatives and potassium thiolacetone in boiling acetone.View full abstractDownload PDF (852K) -
Minoru Yoshimura, Hisao Tsukamoto1962 Volume 10 Issue 7 Pages 566-571
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESS5-Ethyl-5-(1-cyclohexenyl)-4, 6-dioxo-hexahydropyrimidine (ECP), which had beenexpected to display anticonvulsant activity, was prepared by the hydrogenolysis of the corresponding 2-thiobarbituric acid with Raney nickel catalyst, and the mechanism of its biotransformation was discussed.
The transformation of the cyclohexenyl group in 2-thiobarbituric acid derivatives to a cyclohexyl group did not take place when Raney nickel catalyst was prepared by the method of Mozingo.
5-Ethyl-5-(1-cyclohexenyl)-4, 6-dioxo-hexahydropyrimidine (m.p. 269-270°) was obtained in an excellent yields. When administered to rabbits, ECP was partly biotransformed into a metabolite and partly excreted intact in their urine. This metabolite wan confirmed to be 5-ethyl-5-(3'-oxo-1'-cyclohexenyl) barbituric acid by admixture with the oxidation product of ethylhexabit with chromimum trioxide. The characterization and identification of the unchanged ECP as well as a metabolite 5-ethyl-5-(3'-oxo-1'-cyclohexenyl) barbituric acid, were also performed by the color reactions with copper-pyridine and cobaltous nitrate-ammonia, by the paper chromatography, and by the measurement of the ultraviolet and infrared absorption spectra.View full abstractDownload PDF (1033K) -
Manabu Fujimoto, Keiko Okabe1962 Volume 10 Issue 7 Pages 572-575
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSNous avons montré que l'acylètion de la sulfisomézole n'a fourni en générale quedes dérivés N4-acylés et N1, N4-diacylès. Quant a préparation des dérivés N1-acylés, nous avons confirmé avec succes la méthode générale par l'intermédiaire de N-(méthyl-5 isoxazolyl-3) nitro-4 benzènesulfonamide et de 4, 4'-bis [(méthyl-5 isoxazolyl-3) sulfamoyl]-azobenzène.View full abstractDownload PDF (632K) -
Teruo Makino1962 Volume 10 Issue 7 Pages 576-580
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSCompounds of N-[4-(p-alkylphenyl)-2-thiazolyl]-5-nitro-2-furamide (I), N-(5-alkyl-1, 3, 4-thiadiazolyl)-5-nitro-2-furamide (II), and N-(6-alkoxy-3-pyridazinyl)-5-nitro-2-furamide (III) were synthesized to observe their antibacterial and antifungal activity. On the bacteria, ethyl derivative among the compounds of (I) series and, methyl and ethyl derivatives of (III) series were observed to have effects nearly equal to that of nitrofuran.
Antifungal activity of the compounds of three series were more or less effective on both Trichophyton asteroides and Aspergillus fumigatus, but uneffective on the other fungi.View full abstractDownload PDF (744K) -
Tatsuya Horie-Ishida, Kiyokatsu Kinjo, Takeo Ueda1962 Volume 10 Issue 7 Pages 580-591
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSTo find more improved sulfonamide drugs, 3-sulfanilyl-6-hydroxy-, 3-sulfanilyl-6-mercapto-, 3-sulfanilyl-6-alkoxy-and 3-sulfanilyl-6-alkylthio-pyridazine and their intermediates, 3-amino-6-hydroxy-, 3-amino-6-mercapto-, 3-amino-6-alkoxy- and 3-amino-6-alkylthio-pyridazine were synthesized. Few synthetic procedures via different routes were examined as to the synthesises of 3-sulfanilyl-6-alkoxy-, 3-sulfanilyl-6-alkylthio-and 3-amino-6-methoxy-pyridazine.
Activities of the compounds of 6-substituted-3-sulfanilyl-pyridazine on some kinds of bacteria and viruses were examined and among thern, 3-sulfanilyl-6-methoxy-, 3-sulfanilyl-6-ethoxy and 3-sulfanilyl-6-methylthiopyridazine were found to exert remarkableantibacterial effects.View full abstractDownload PDF (2027K) -
Tatsuya Horie, Tatsuya Ishida, Takeo Ueda1962 Volume 10 Issue 7 Pages 591-595
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSIn order to find antimicrobial agents, compounds of 6-substituted 3-(p-nitrophenylsulfonamido) pyridazine, 6-substituted 3-(p-tolylsulfonamido) pyridazine and 6-substituted 3-(p-aminomethylphenylsulfonamido) pyridazine were synthesized and screened as to their activities on Staph. aureus and E. coli, but any of them was found uneffective.View full abstractDownload PDF (746K) -
Studies on Pyridazine Derivatives. III. Improved Synthetic Method of 3-Sulfanilyl-6-alkoxypyridazineTatsuya Horie, Tatsuya Ishida, Takeo Ueda1962 Volume 10 Issue 7 Pages 595-602
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSFor the purpose of industrial application, some new synthetic methods of 3-sulfanilyl-6-alkoxypyridazine were examined and the reaction of 3-(p-acetamidophenylsulfonamido)-6-chloropyridazine with sodium alkoxide in the corresponding alcohol was found to produce 3-sulfanilyl-6-alkoxypyridazine and the corresponding alkyl ester of acetic acid in both excellent yields. To investigate the mechanisms of this reaction, 3-(p-acetamidophenylsulfonamido)-6-chloropyridazine, 3-(p-acetamidophenylsulfonamido)-6-methoxypyridazine and 3-sulfanilyl-6-chloropyridazine were reacted with sodium methoxide in methanol under various conditions, and estimated the percentages of deacetylation and methoxylation by determining the amount of ester and sodium acetate and chlorine ion. From these results, it was found that the deacetylation and the methoxylation proceeded simultaneously in this reaction of two points, and the objective compound 3-sulfanilyl-6-methoxypyridazine was produced in a good yield. Thus, this method was found available for the industrial production of 3-sulfanilyl-6-methoxypyridazine.View full abstractDownload PDF (1343K) -
Kotaro Takahashi, Shuichi Miyashita1962 Volume 10 Issue 7 Pages 603-607
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSMethyldihydrousnic acid was obtained by methylation of dihydrousnic acid and itsconstitution was elucidated as (I). The result that 3'-methyl-2', 6'-dihydroxyacetophenone was obtained from methyldihydrousnic acid indicates that the resorcinol type of compound is derived from B-ring of (I). This result also presents the experimental proof of formation of 3'-methyl-2', 6'-dihydroxyacetophenone, one of resorcinol type of compound, from B-ring of dihydrousnic acid.View full abstractDownload PDF (902K) -
Kotaro Takahashi, Akie Arai, Kazuko Oshima, Yoshie Ueda, Shuichi Miyas ...1962 Volume 10 Issue 7 Pages 607-611
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe constitution of methylusnic acid, the methylation product of usnic acid withdimethyl sulfate and sodium hydroxide, first reported by A. Robertson et al. was reinvestigated and elucidated as (I).View full abstractDownload PDF (877K) -
Yasuo Makisumi1962 Volume 10 Issue 7 Pages 612-620
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSCondensation of 1, 3-dicarbonyl compounds with 5-aminopyrazole (III) and its 3-carboxylic ester (X) was examined and several kinds of 5, 7-disubstituted pyrazolo [1, 5-a]-pyrimidines were obtained. It was observed by the infrared spectrum that the hydroxyl group at 5- and 7-positions of pyrazolo [1, 5-a] pyrimidine ring shows the lactam form in the neutral mediumView full abstractDownload PDF (1515K) -
Yasuo Makisumi1962 Volume 10 Issue 7 Pages 620-626
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSCondensation of 2-ethoxymethylene-1, 3-dicarbonyl compounds with 5-aminopyrazole (I) was examined and several kinds of 6, 7-disubstituted pyrazolo [1, 5-a] pyrimidines were obtained. In the reaction of ethyl 2-cyano-3-ethoxyacrylate with (I), ethyl 2-cyano-3-(5-Dvrazolylamino) acrylate (II) as the intermediate was isolated.View full abstractDownload PDF (1159K) -
Takeo Naito, Tomoyoshi Kawakami1962 Volume 10 Issue 7 Pages 627-632
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSFrom the reaction mixtures of D-ribose or D-xylose and urea, two anomeric pairs of D-ribopyranosyl- and D-xylopyranosylureas were separated by a Celite column. These ureides, after acetylation followed by condensation with 2-methyl-3-methoxyacryloyl chloride, afforded the intermediates, the cyclisation of which produced two anomeric pairs of D-ribopyranosyl- and D-xylopyranosylthymines.View full abstractDownload PDF (1143K) -
Tsutomu Momose, Yo Ueda, Masatake Iwasaki1962 Volume 10 Issue 7 Pages 633-634
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSIn the Tollens reaction and fused reaction, mannuronic acid and galacturonic acid proved to react with 1, 3-naphthalendiol in the same mechanism as glucuronic acid by isolating the coloring matters in a crystalline form.View full abstractDownload PDF (294K) -
Yoshio Hirose, Naohisa Sasaki, Eiko Kawagishi, Susumu Nonomura1962 Volume 10 Issue 7 Pages 634-636
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSIt was shown that the hydroxymethylation of 1, 3, 5-trihydroxyanthraquinone (IC) took place at 2-position of its molecule.View full abstractDownload PDF (333K) -
Hiroyuki Ageta, Kenji Iwata, Yoshiyuki Ootake1962 Volume 10 Issue 7 Pages 637
Published: July 25, 1962
Released on J-STAGE: January 31, 2011
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Seigo Fukushima, Akira Ueno, Hisayo Maekawa1962 Volume 10 Issue 7 Pages 638
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
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Tomoharu Okuda, Makoto Suzuki, Tamotsu Furumai, Hiroko Takahashi1962 Volume 10 Issue 7 Pages 639-640
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSDownload PDF (318K) -
Hiroshi Hikino, Yasuko Hikino, Itiro Yosioka1962 Volume 10 Issue 7 Pages 641-642
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
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Takanobu Itai, Sachiko Natsume1962 Volume 10 Issue 7 Pages 643-645
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
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Hiroshi Ishii, Takehiko Tozyo, Daisuke Satoh1962 Volume 10 Issue 7 Pages 645-646
Published: July 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSDownload PDF (269K)
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