巻号一覧
11 巻, 11 号
選択された号の論文の23件中1～23を表示しています
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池原 森男, 大塚 栄子1963 年 11 巻 11 号 p. 1353-1358
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーThe phosphorylation of unprotected nucleoside, 9-D-erythrityladenine and adenosine, was attempted by the use of P1-diphenyl P2-morpholino pyrophosphorochloridate. Whereas in the former case 23% of 4'-monophosphate was obtained, the yield of 5'-AMP was very low. Isopropylideneadenosine was phosphorylated with Vilsmeier complex derived from morpholinophosphorodichloridate in 50% yield. The use of DMF in the reaction of isopropylidene-AMP-morpholidate was also investigated. 2', 3'-O-Isopropylidene-ATP was synthesized and characterized.抄録全体を表示PDF形式でダウンロード (685K) -
池原 森男, 大塚 栄子1963 年 11 巻 11 号 p. 1358-1363
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーA new synthesis of thymidine 5'-triphosphate was achieved by the phosphorylation with P1-diphenyl P2-morpholino pyrophosphorochloridate of 3'-O-acetylthymidine, followed by the reaction with pyrophosphate salt and alkaline removal of acetyl group. The reaction of 2', 3'-O-isopropylideneadenosine 5'-phosphoromorpholinochloridate with P1, P2-di-(2-cyanoethyl) pyrophosphate was also investigated. After the alkaline removal of protecting groups only isopropylidene-ADP was obtained.抄録全体を表示PDF形式でダウンロード (646K) -
百瀬 勉, 大倉 洋甫, 平内 三政1963 年 11 巻 11 号 p. 1364-1368
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーA crystalline dye was separated from the reaction mixture of anthrone with furfural or xylose in sulfuric acid, and its probable structure was presented. The same dye was also yielded by condensing anthrone to another dye which was separated from the reaction mixture of the same reagents in phosphoric acid.抄録全体を表示PDF形式でダウンロード (570K) -
高見沢 映, 平井 健太郎, 浜島 好男, 佐藤 久夫1963 年 11 巻 11 号 p. 1368-1375
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーThe new thiamine derivatives, O-substituted derivatives of thiamine propyl disulfide, disulfide derivatives of thiamine and 2-hydroxy-3-carbamoyloxypropyl, 2-ethoxycarbonylethyl, 2-ethoxycarbonyloxyethyl, and their O-substituted derivatives were prepared. Also, O-2-tetrahydropyranyl derivatives of S-alkoxycarbonyl thiamine and thiamine propyl disulfide were prepared, and their primary screening tests were made.抄録全体を表示PDF形式でダウンロード (886K) -
高橋 史郎, 加納 日出夫1963 年 11 巻 11 号 p. 1375-1381
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーPreviously unknown 1-substituted benzimidazole 3-oxides were synthesized by reductive ring-closure of N-acyl-N-substituted-o-nitroanilines. From the ultraviolet absorption spectra, it was shown that benzimidazole N-oxide exists as the N-oxide form in aqueous solution and as the N-hydroxyl form in ethanol solution.抄録全体を表示PDF形式でダウンロード (703K) -
高木 要, 上田 武雄1963 年 11 巻 11 号 p. 1382-1388
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーTo search for antimicrobial agent, 2-hydrazino-4-alkoxy-6-methylpyrimidine, 2-hydrazino-4-alkylthio-6-methylpyrimidine, and 2-alkylthio-4-hydrazino-6-methylpyrimidine were synthesized by the hydrazination of the corresponding 2-chloro- and 4-chloropyrimidine with hydrazine hydrate, and it was found that chlorine atom at 2-position or 4-position in pyrimidine ring, is more reactive on hydrazine than alkylthio and alkoxy group at 4- or 2-position. These hydrazinopyrimidines of the three series were converted into pyrimidinylhydrazones of 4-biphenylylglyoxal by the condensation with 4-biphenylylglyoxal.抄録全体を表示PDF形式でダウンロード (685K) -
野上 寿, 福沢 寿, 仲井 由宣1963 年 11 巻 11 号 p. 1389-1398
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーThe effects of the penetrating rate on tablet disintegration were examined. Viscosity, surface tension, contact angle of liquid and the mean capillary diameter of tablet were measured and their effects on disintegration were discussed. In high viscosity solution, the rate of penetration decreased and the disintegration was not well. The viscosity of gastric juice was measured and tablet disintegration in human gastro-intestinal tract was examined by X ray. It was estimated that a tablet disintegration might be affected by the viscosity of gastric juice. The rate of penetration of powder in a surfactant solutions and the penetration of the powder coated by surfactant in pure water were measured. The effect of surfactant on disintegration could not be generally expected due to the decrease of surface tension. The mean diameter of open capillary in a tablet was measured by air permeametry. The diameter was decreased by a large compressional force in tableting and increased by a large quantity of disintegrator. The equation of penetrating rate was discussed theoretically to apply it for the penetrating in tablet capillary. It was concluded that Washburn's equation of penetrating rate could be applied to the penetrating in the capillary of a tablet.抄録全体を表示PDF形式でダウンロード (988K) -
浮田 忠之進, 奥山 治美, 早津 彦哉1963 年 11 巻 11 号 p. 1399-1404
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーThe reaction of ethylene oxide with uridine derivatives in an aqueous solution at room temperature was investigated. 1-Methyluracil gave 1-methyl-3-(2-hydroxyethyl)-uracil (II) quantitatively upon reaction with ethylene oxide at pH 10. The reaction of uridine with ethylene oxide at neutral pH results in the formation of 3-(2-hydroxyethyl)-uridine (IV) quantitatively. These products, II and IV, were isolated as crystals and the structure well defined. The rate of N3-alkylation of uridine increases with the increase of pH value. This indicated that the reaction proceeds through the dissociated form of uridine. At a high-pH region, alkylation of the hydroxyl group(s) of ribose moiety took place concomitantly with the N3-alkylation and gave multiply 2-hydroxyethylated derivatives of uridine. In the reaction of uridine 5'-phosphate with ethylene oxide, besides the N3-hydroxyethylation, phosphodiester formation was also observed. In a high-pH solution, the hydroxyethylation of sugar-hydroxyl group(s) took place as in the case of uridine. Synthesis of uridine 5'-phosphate 2-hydroxyethyl ester by the reaction of uridine 5'-phosphate with ethylene glycol in the presence of dicyclohexyl carbodiimide was described.抄録全体を表示PDF形式でダウンロード (750K) -
山川 浩司, 谷川 啓一, 荒川 基一1963 年 11 巻 11 号 p. 1405-1408
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーGas chromatography of twenty kinds of metal acetylacetonates [Al (III), Ba (II), Be (II), Ca (II), Cd (II), Co (II), Co (III), Cr (III), Cu (II), Fe (III), Mg (II), Mn (II), Mn (III), MoO2 (VI), Ni (II), Th (IV), Ti (III), VO (IV), Zn (II), and Zr (IV)] was investigated, using various liquid-phase column. Analysis of the metal chelates was effected by the use of a column of 0.5% silicon polymers (SE-30, SE-52, and QF-1) on glass microbeads.抄録全体を表示PDF形式でダウンロード (486K) -
森 弘, 和田 俊洋1963 年 11 巻 11 号 p. 1409-1413
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーSome hydroxy-steroids were transformed into the corresponding chloro-steroids with Walden inversion, when treated with sulfuryl chloride in pyridine ; testosterone (I), 4-chlorotestosterone (IV), 17β-hydroxy-5α-androstan-3-one (V), 5α-androstane-3β, 17β-diol 3-acetate (VIII), and estradiol 3-benzoate (IX) were introduced to the corresponding 17α-chloro compounds, II, III, VI, VIIa, and X, respectively. From androsterone (XI) and isoandrosterone (XIV) were obtained 3β-chloro-5α-androstan-17-one (XII) and 3α-chloro-5α-androstan-17-one (XIII) respectively.抄録全体を表示PDF形式でダウンロード (585K) -
森 弘, 常田 清1963 年 11 巻 11 号 p. 1413-1417
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリー17β-Chloro-5α-androstan-3β-ol (VII) and 17β-chloro-5α-androstan-3-one (VI) were prepared. 3β-Hydroxy-5α-androstan-17-one hydrazone (II) was treated with N-chlorosuccinimide in pyridine to give 17-chloro-5α-androst-16-en-3β-ol (IVa), which on hydrogenation with 5% palladium charcoal afforded VII. The chromium trioxide oxidation of VII gave VI. Some observations concerning 17-bromo and 17-iodo compounds (IVb and III) were also written.抄録全体を表示PDF形式でダウンロード (594K) -
森 弘, 山田 〓治1963 年 11 巻 11 号 p. 1418-1423
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーSome 3β-acetoxy-5-ene steroids were reacted with sulfuryl chloride in pyridine and the corresponding 3β-acetoxy-5α, 6β-dichloro steroids were obtained. Dehydroepiandrosterone acetate (VII) was transformed into 5α, 6β, 16, 16-tetrachloro compound (VI) on treatment with sulfuryl chloride in chloroform. The reaction of androst-5-ene-3, 17-dione (IX) with sulfuryl chloride in pyridine gave 6α-chloroandrost-4-ene-3, 17-dione (X), whereas the same reaction on pregn-5-ene-3, 20-dione (V) afforded the corresponding 5α, 6β-dichloro compound (IIIa). Some transformations of compounds above-mentioned were also written.抄録全体を表示PDF形式でダウンロード (762K) -
砂川 玄俊, 佐藤 裕信, 綿谷 充雄1963 年 11 巻 11 号 p. 1423-1431
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリー3-Substituted 5-nitrosotropolone (IIIa∼c), 7H-cyclohepta [b] pyrazin-7-one oxime (VIIIa, b), 8H-cyclohepta [b] quinoxalin-8-one oxime (IXa∼c), 9H-cyclohepta [b] naphtho [2, 3-e] pyrazin-9-one oxime (X), 5-nitrosotropolone guanidine adduct (XI), 2-(2-acetylhydrazino)-5-nitrosotropone (XII and its analogues) and 2-(2-troponylhydrazino)-5-nitrosotropone (XIV) were synthesized according to the schemes shown in Chart 1, 2, and 3. In addition, some reactions related to IIIa and IIIc were described. Among these derivatives, 2-(2-isonicotinoylhydrazino)-5-nitrosotropone and its N-oxide showed remarkable anti-tumor activities on ascitic and solid forms of Ehrlich tumor and Sarcoma 180.抄録全体を表示PDF形式でダウンロード (861K) -
佐藤 裕信1963 年 11 巻 11 号 p. 1431-1440
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリー3-Aryl-5-hydroxycyclohepta [b] pyrrol-6 (1H)-one were synthesized by the similar manner as previously described. Nitration of 5-hydroxycyclohepta [b] pyrrol-6 (1H)-one derivatives (VII and Va) gave mononitro derivatives (VIIIa and VIIIb). The properties of the mononitro derivatives (VIIIa and VIIIb) were examined and it was discovered that VIIIa and VIIIb underwent rearrangement by aqueous alkali to 4-nitroindole derivatives (Xa and Xb). In order to determine the structure of the products being obtained by the rearrangement reaction, the cyclization of phenylpyruvic acid 4-carboxy-3-nitrophenylhydrazone (XIVa) was investigated. Moreover, the nitro groups of the products were proved to be in 4-potition by infrared spectra analysis and oxidative degradations. Therefore, above-mentioned mononitro derivatives were established to be 4-nitro-5-hydroxycylohepta [b] pyrrol-6 (1H)-one derivatives.抄録全体を表示PDF形式でダウンロード (1075K) -
佐藤 裕信1963 年 11 巻 11 号 p. 1440-1445
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーBromination of 5-hydroxycyclohepta [b] pyrrol-6 (1H) -one was examined. Namely, bromination of 2-ethoxycarbonyl-5-hydroxy-3-phenylcyclohepta [b] pyrrol-6 (1H)-one (Ib) afforded only 4-bromo-2-ethoxycarbonyl-5-hydroxy-3-phenylcyclohepta [b] pyrrol-6 (1H)-one (IIb), and 5-hydroxy-3-phenylcyclohepta [b] pyrrol-6 (1H) -one (VI) afforded 2-bromo (VII), and 2, 4-dibromo-5-hydroxy-3-phenylcyclohepta [b] pyrrol-6 (1H)-one (VIII). Hydrolysis of IIb with alkali afforded 4-bromo-2-carboxy-5-hydroxy-3-phenylcyclohepta [b] pyrrol-6 (1H)-one (III) without rearrangement reaction. Reaction of III with aqueous ammonia afforded 2-carboxy-4, 5-dihydroxy-3-phenylcyclohepta [b] pyrrol-6 (1H)-one (V). A sevenmembered ring compound having a similar structure to serotonin, 3- (2-aminoethyl) -2-carboxy-5-hydroxycyclohepta [b] pyrrol-6 (1H)-one hydrochloride (XII) was prepared.抄録全体を表示PDF形式でダウンロード (719K) -
赤星 三彌, 加藤 俊雄, 雑賀 昭助1963 年 11 巻 11 号 p. 1446-1451
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーThe Pschorr reaction of 1- (2-amino-4, 5-methylenedioxyphenethyl) pyridinium (Va'), 1- (2-amino-4, 5-dimethoxyphenethyl) pyridinium (Vb) and 1- (2-amino-4, 5-dimethoxyphenethyl) picolinium (Vc) salts was carried out and the corresponding cyclized product was obtained respectively. 2-Amino-1- (3, 4-methylenedioxyphenethyl) pyridinium salt was prepared and its Pschorr reaction was investigated.抄録全体を表示PDF形式でダウンロード (713K) -
三橋 博, 佐々木 希吉, 清水 譲1963 年 11 巻 11 号 p. 1452-1455
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーThe whole plant of Perugularia extensa N. E. Br. was proved to contain a glycoside mixture which showed strong Keller-Kiliani reaction, suggesting the presence of a 2-deoxy-sugars in the sugar part. The sugar fraction obtained by acid hydrolysis was found to contain D-cymarose, D-sarmentose, L-oleandrose, and D-glucose by a paper chromatographic comparison with authentic specimens. Uzarigenin and a new glycoside (m.p. 244∼248°) were found.抄録全体を表示PDF形式でダウンロード (516K) -
池原 森男, 大塚 栄子, 児玉 喜博1963 年 11 巻 11 号 p. 1456-1461
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーBy the reaction of 2, 6-lupetidine with phosphorus oxychloride a new phosphorylating agent, 2, 6-lupetidylphorodichloridate was synthesized. Unprotected adenosine was phosphorylated with this reagent on 5'-hydroxyl group in a yield around 15%.抄録全体を表示PDF形式でダウンロード (736K) -
赤木 満洲雄, 三沢 隆行, 金島 弘恭1963 年 11 巻 11 号 p. 1461-1464
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーBoth the levels of fructose-6-phosphate (F6P) and fructose 1, 6-diphosphate (FDP) in biological materials such as livers, brains, kidneys and blood of rats and guinea pigs were investigated at 4 hours after oral administration of borax in a single dose of 140 mg. and 240 mg./kg. as boron to the former animals and to the latter respectively, and boron effects upon anaerobic glycolysis were also examined with liver homogenates and brain homogenates of rats. FDP levels in livers of these animals received borax had a tendency to rise obviously within 4 hours. Anaerobic glycolysis of glucose was found to be inhibited considerably by boron (0.01 M boric acid), being the inhibition rates higher with liver homogenates than with brain homogenates of rats.抄録全体を表示PDF形式でダウンロード (440K) -
吉岡 一郎, 中西 勤1963 年 11 巻 11 号 p. 1468-1470
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (417K) -
西村 卓三, 清水 文治, 岩井 一成1963 年 11 巻 11 号 p. 1470-1472
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (390K) -
井下田 浩1963 年 11 巻 11 号 p. 1472-1473
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (350K) -
津田 恭介, 田村 千尋, 太刀川 隆治, 酒井 浄, 甘粕 治, 河村 正朗, 生熊 晋1963 年 11 巻 11 号 p. 1473-1475
発行日: 1963/11/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (406K)
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