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Volume 11, Issue 7
Displaying 1-25 of 25 articles from this issue
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Yasuhiko Sato, Shiro Nishioka, Osamu Yonemitsu, Yoshio Ban1963 Volume 11 Issue 7 Pages 829-834
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS(+)-3-Oxocyclopentanecarboxylic acid was chemically correlated with (+)-3-carboxyadipic acid and with (+)-3-methylcyclopentanone, both of which are of known absolute configurations. This correlation established that the natural sarkomycin, (-)-2-methylene-3-oxocyclopentanecarboxylic acid, is represented by the formula (XXXII), of which C-1 is S.View full abstractDownload PDF (630K) -
Shigeharu Tanayama, Michio Ui1963 Volume 11 Issue 7 Pages 835-842
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA salicylaldehyde method for microdetermination of blood ketone bodies was extensively studied. A wide variety of factors influencing the oxidation of keto acids to acetone and color development was examined, and a simple and sensitive method was standardized by which periodical analysis of ketone bodies on 0.1 ml. of rat whole blood can be routinely performed.View full abstractDownload PDF (833K) -
Setsuo Kiryu, Sadao Iguchi1963 Volume 11 Issue 7 Pages 843-845
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSIt was definitely found that dehydroacetic acid had two kinds of crystals, one of which was α-form (monoclinic), stable at a low temperature, and the other was β-form (triclinic), stable at a high temperature. Transition from α-form to β-form occurred at 80°. Lattice constants and other crystal data of these two kinds of crystals were reported.View full abstractDownload PDF (501K) -
Yasuo Makisumi1963 Volume 11 Issue 7 Pages 845-850
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSTen kinds of alkoxy-s-triazolo [1, 5-a] pyrimidines were synthesized by reaction of the corresponding chloro derivatives with sodium alkoxides and the transetherification reaction of these compounds was investigated. It was clear that the alkoxyl group at 7-position was transetherified more easily than that at 5-position in s-triazolo [1, 5-a]-pyrimidines.View full abstractDownload PDF (737K) -
Yasuo Makisumi1963 Volume 11 Issue 7 Pages 851-859
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThermal rearrangement of 5-methyl-7-allyloxy-s-triazolo [1, 5-a] pyrimidine (II) was investigated and seven kinds of products ; an unknown oil, 5-methyl-s-triazolo [1, 5-a] pyrimidin-7-ol (III), its 6-allyl derivative (IV), 3-and 4-allyl-5-methyl-s-triazolo [1, 5-a] pyrimidin-7 (3H and 4H)-ones (IIIb and IIIa), and their 6-allyl derivatives (IVb and IVa) were obtained. In order to confirm the structure of these products, the condensation of ethyl acetoacetate or its 2-allyl compound with N-allyl derivatives (Va and Vb) of 5-amino-s-triazole was examined. On the other hand, allylation of III and IV afforded the 3- and 4-allylated products which were respectively identified with the compounds (IIIa, IIIb and IVa, IVb) obtaining by the thermal rearrangement of II. The mechanism of the above thermal rearrangement reaction was discussed.View full abstractDownload PDF (1000K) -
Yasuo Makisumi1963 Volume 11 Issue 7 Pages 859-866
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe thermal rearrangement of 7-allyloxy-5, 6-dimethyl-s-triazolo [1, 5-a] pyrimidine (III) was carried out and five kinds of rearrangement products ; 3- and 4-allyl-5, 6-dimethyl-s-triazolo [1, 5-a] pyrimidin-7 (3H and 4H) -ones (Ib and Ia), 5- (3-butenyl) -6-methyl-s-triazolo [1, 5-a] pyrimidin-7-ol (IV), and its 3- and 4-allyl derivatives (IVb and IVa) were obtained. Among these products, the out-of-ring Claisen rearrangement product (IV) was obtained in 66% yield. This reaction is the first example of out-of-ring migration of an allyl group to an active methyl group.View full abstractDownload PDF (869K) -
Kenichi Takeda, Hitoshi Minato, Satoko Nosaka, Ichiro Ishizuka1963 Volume 11 Issue 7 Pages 867-871
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSWhen α-guaiene (II) was hydrogenated with palladium charcoal as a catalyst under neutral or acid conditions, it gave a mixture of α-dihydroguaiene (IV) and its double bond isomer. The constitution of the latter was established as V.View full abstractDownload PDF (537K) -
Toyozo Uno, Hiroyuki Yasuda, Yutaka Sekine1963 Volume 11 Issue 7 Pages 872-875
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSMetabolic product of sulfadiazine excreted in the urine after its oral administration was examined chiefly through paper chromatography and paper electorophoresis. It was thereby found that the substances excreted are sulfadiazine, N4-acetylsulfadiazine, sulfadiazine-N4-glucuronide, sufladiazine-N4-sulfonate and sulfanilamide.View full abstractDownload PDF (511K) -
Hitoshi Minato, Ariyoshi Shimaoka1963 Volume 11 Issue 7 Pages 876-881
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSIn order to find a proto-sapogenin of luvigenin (III), the structural investigation of the unknown sapogenins from Metanarthecium luteo-viride MAXIM was attempted. Isonarthogenin (Va), narthogenin (VIa) and neonogiragenin (XIIIa) were isolated, and the former two sapogenins were established to be steroidal sapogenins having a hydroxyl group at C-27.View full abstractDownload PDF (706K) -
Akira Takamizawa, Kentaro Hirai, Yoshio Hamashima1963 Volume 11 Issue 7 Pages 882-887
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDirect introduction of substituents of organic groups to the hydroxyl group of thiamine was achieved by the use of phosgene. O-Chlorocarbonylthiamine (VI) thus prepared was converted into O-carbamoylthiamine and O-alkoxycarbonylthiamine. The free bases of O-carbamoyl derivatives were assigned dihydrothiochrome structures (XV) and (XVI). S-Carbamoylthiamine derivatives were also prepared. Application of S→O rearrangement of the carbamoyl group gave various O, S-bis substituted thiamine derivatives.View full abstractDownload PDF (743K) -
Minoru Sekiya, Keiichi Ito1963 Volume 11 Issue 7 Pages 888-891
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSN-Benzylidene-α-acetamidobenzylamine reacted with dialkylamines in the presence of methylamine or ammonia affording compounds of new benzylidenediamine type, N- (α-dialkylaminobenzyl) acetamides. By using piperidine, morpholine, dibenzylamine, and N-methylbenzylamine as the secondary amine reactant the corresponding products were obtained. A mechanism for this reaction was suggested.View full abstractDownload PDF (517K) -
Minoru Sekiya, Keiichi Ito1963 Volume 11 Issue 7 Pages 892-894
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe catalytic hydrogenolysis of some compounds that are classified as N-hydroxy-methylamides, N-dialkylaminomethylamides, and N- (α-dialkylaminobenzyl) amides was carried out using Raney nickel catalyst under high pressure of hydrogen. It was found in every case that the hydrogenolysis took place at the carbon bond connecting to nitro gen in the amide group.View full abstractDownload PDF (472K) -
Minoru Sekiya, Akira Hara1963 Volume 11 Issue 7 Pages 895-901
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSCatalytic hydrogenation of some azomethines, such as N-benzylideneaniline, N-benzylidenebenzylamine, and N- (4-methoxybenzylidene) phenethylamine in the presence of amide was examined under high pressure of hydrogen. The reaction resulted in conversion, ArCH=NR+2R'CONH2+H2→ArCHNHCOR'+RNHCOR'+NH3, particularly in excellent yields with formamide. With regard to this reaction path, it was recognized that the initiating essential reaction between azomethine and formamide would be the reaction, ArCH=NR+HCONH2→ArCH=NH+RNHCHO (NH3 acts as a catalyst), which was demonstrated by using N-benzylidene-4-sulfonamidobenzylamine as azomethine. Based on this reaction, the whole pathway for the above hydrogenation reaction was proposed. Mechanism for hydrogenation reaction of nitriles, oximes, and ammoniaaldehyde mixtures in the presence of formamide was also suggested.View full abstractDownload PDF (823K) -
Minoru Sekiya, Akira Hara1963 Volume 11 Issue 7 Pages 901-905
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSFormation of N-arylmethylene-1-acylamino-1-arylmethylamine resulted in some cases when aromatic aldehyde-ammonia mixture or hydrobenzamide was allowed to react with amide. In the light of this fact the mechanism comprehensive for all the reactions which lead to the formation of N-arylmethylene-1-acylamino-1-arylmetylamine was proposed.View full abstractDownload PDF (601K) -
Koji Yamakawa, Hisao Ochi, Kiichi Arakawa1963 Volume 11 Issue 7 Pages 905-911
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSOxidation of 1, 1'-diacetylferrocene with sodium hypochlorite and iodine-pyridine gave 1, 1-ferrocenedicarboxylic acid (III) and 1-acetyl-1'-ferrocenecarboxylic acid (VI), respectively. The polyester polymer of ferrocene was obtained from dimethyl-1, 1'-ferrocenecarboxylate (V) and ethylene glycol. 1, 1'-Bis (1-hydroxyethyl) ferrocene (VIII) was converted to 1, 1'-(1, 1'-epoxydiethyl) ferrocene (IX) by chromatographic method or with p-toluenesulfonyl chloride. Stereochemistry of the cyclic dimethyl ether (IX) is discussed. Treatment of 1, 1'-ferrocenedicarboxylic acid with N, N'-dicyclohexylcarbodiimide gave N, N'-dicyclohexyl-N. N' -bis (cyclohexylcarbamoyl) -1, 1'-ferrocenedicarboxamide (XIV).View full abstractDownload PDF (797K) -
Takeo Ueda, Tadakazu Tsuji, Hiroko Momona1963 Volume 11 Issue 7 Pages 912-917
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe replacement of 4-hydroxyl group of aminopyrimidinols by sulfhydryl in one step, through the action of phosphorus pentasulfide in triethylamine or 3-picoline. 5-Acylamino-6-amino-4-pyrimidinols were treated with phosphorus pentasulfide in pyridine, to yield thiazolo [5, 4-d] pyrimidine and 6-purinethiol compounds. The yield of both two type compounds were changed according to a functional group in the starting substance. These products, in addition, other 6-purinethiol and related compounds were screened as to their antiviral activities on poliomyelitis virus. Any of the compounds, however, did not exert a significant activity on the virus.View full abstractDownload PDF (674K) -
Kazuya Kunugi1963 Volume 11 Issue 7 Pages 918-921
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSConcerning with the alcoholyses reactions of methyl stearate by sucrose, rate study was carried out. Sucrose and methyl stearate were alcoholized in dimethylformamide at various molar ratios. The rates of reactions were analyzed assuming that they were of the second order, and the validity of this assumption was proved. The velocity constant at any molar ratio gave a good accordance and was determined to be 0.3∼0.4 L. mole-1 hr-1.View full abstractDownload PDF (451K) -
Kazuya Kunugi1963 Volume 11 Issue 7 Pages 922-925
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAs one of the important problems in purifications of sucrose fatty acid ester, a new food-additive, its deacidification was investigated. The method of ion exchange in a non-aqueous medium was carried out, and it was concluded that the deacidification of sucrose ester was performed by treatment with anion exchange resin after treatment with cation exchange resin or inorganic acid. A small amount of water contained in the solvent was effective to accelerate the exchange reaction. Decoloration by the ion exchange resins was also observed.View full abstractDownload PDF (505K) -
Shoji Shibata, HsuchChing Chiang1963 Volume 11 Issue 7 Pages 926-930
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe structure of grayanic acid, C23H26O7, m.p. 186∼189°which was isolated from Cladonia Grayi MERRILL has been established to be an orcinol-type depsidone as formulated (II).View full abstractDownload PDF (574K) -
Yutaka Asahi1963 Volume 11 Issue 7 Pages 930-938
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThioacetazone gives 2 steps of 2-electron reduction waves in acid media, which are ascribed to a reductive cleavage of the N-N bond in the protonated thioacetazone and a saturation of the -CH=N- group, respectively. Precedence of the protonation of base on the electrode causes in a kinetic current. In alkaline media, thioacetazone gives other reduction wave due to a 2-electron reduction of the -CH=N- group in the free base, and an anodic wave which are ascribed to the formation of a mercurous complex on the electrode. The reduction waves of benzaldehyde thiosemicarbazone and p-acetamidobenzaldehyde semicarbazone and the first reduction wave of S-methylthioacetazone are also ascribed to the reaction as similar as that of thioacetazone. The second reduction wave of S-methylthioacetazone as well as the reduction waves of S-methylisothiourea and S-ethylisothiosemicarbazide are assumed to be due to the reduction of the RSC=NH group. p-Acetamidobenzaldehyde shows 2 steps of 1-electron reduction waves at pH about 4, which overlap together and diminish at higher pH. Thiosemicarbazides in alkali give and anodic wave due to a reaction with mercurous ion.View full abstractDownload PDF (1022K) -
Shunji Ishikura, Keiko Yokota1963 Volume 11 Issue 7 Pages 939-942
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA simple, sensitive analytic method for measuring to differentiate inorganic mercury and phenylmercury acetate has been developed. The method is found useful for analysis of mercurials used extensively as drug in medical and agricultural fields. An acidified sample solution was extracted with dithizone-carbon tetrachoride solution, the carbon tetrachloride layer was chromatographed on an alumina column, and the separated dithizonate solutions were measured by photoelectric colorimeter. By means of the method here reported, organic and inorganic mercury can be separately determined at levels to 0.02 p.p.m. with an error not exceeding 5%, using a minute amounts of materials and without subjecting it to the tedious procedure of preliminary oxidative degradation. This method is not disturbed by other metal ions. Stabilization of dithizonates is described.View full abstractDownload PDF (495K) -
Hisashi Nogami, Yoshio Kanakubo1963 Volume 11 Issue 7 Pages 943-947
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe hydrolysis of sodium octyl (SOS), myristyl (SMS) and cetyl sulfate (SCS) as sodium lauryl sulfate (SLS) homologue and that of sodium pentadecane-8-sulfate (SPS) as secondary alcohol sulfate in hydrochloric acid solution were studied. 1) It was recognized that the sodium alkyl sulfates were relatively stable below their critical micelle concentration (CMC) and less stable above their CMC as well as SLS. Accordingly, this phenomenon was ascribed to the micellization and the ionic atmosphere around the micelle of the sodium alkyl sulfate. 2) The sodium normal alkyl sulfate with the longer alkyl chain length was less stable than the shorter chain length. It was thought that the micelle with the longer alkyl chain length was more affected by gegen-ion than the shorter chain length.View full abstractDownload PDF (527K) -
Seigoro Hayashi, Hiroshi Ueki, Yoko Ueki, Hiroyuki Aoki, Kanji Tanaka, ...1963 Volume 11 Issue 7 Pages 948-951
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSixteen of the quinone derivatives were examined for the antitumor activity against Ehrlich ascites tumor cell by the cylinder agar plate method and for the antibacterial activity against Staphylococcus aureus TERASHIMA and Esherichia coli. Any relationship were not found between the antitumor and the antibacterial activity.View full abstractDownload PDF (356K) -
Fumio Yoneda, Takayuki Ohtaka, Yoshihiro Nitta1963 Volume 11 Issue 7 Pages 954-956
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (408K) -
Kazuo Tori, Tetsuo Tomita, Hiroshi Itazaki, Masayuki Narisada, Wataru ...1963 Volume 11 Issue 7 Pages 956-959
Published: July 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (476K)
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